SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 PHE A 208
LEU A  56
SER A 184
 None
 0.91A 1e7aA-1tffA:
0.1		 1e7aA-1tffA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 GLU A 194
TYR A 217
PHE A  39
 None
 0.81A 1eqbB-1tffA:
undetectable		 1eqbB-1tffA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 GLU A 194
TYR A 217
PHE A  39
 None
 0.81A 1eqbA-1tffA:
undetectable		 1eqbA-1tffA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 GLU A 194
TYR A 217
PHE A  39
 None
 0.81A 1eqbD-1tffA:
undetectable		 1eqbD-1tffA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 GLU A 194
TYR A 217
PHE A  39
 None
 0.81A 1eqbC-1tffA:
undetectable		 1eqbC-1tffA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.72A 1rjoA-1tffA:
undetectable		 1rjoA-1tffA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.66A 1rkyA-1tffA:
undetectable		 1rkyA-1tffA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.72A 1w2zA-1tffA:
undetectable		 1w2zA-1tffA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.68A 1w2zB-1tffA:
undetectable		 1w2zB-1tffA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.70A 1w2zC-1tffA:
undetectable		 1w2zC-1tffA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.67A 1w2zD-1tffA:
undetectable		 1w2zD-1tffA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 11 LEU A  61
LEU A  64
THR A  81
PRO A  82
LEU A  56
 None
 0.97A 2ft9A-1tffA:
undetectable		 2ft9A-1tffA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.70A 2oqeA-1tffA:
undetectable		 2oqeA-1tffA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.71A 2oqeB-1tffA:
undetectable		 2oqeB-1tffA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.71A 2oqeC-1tffA:
undetectable		 2oqeC-1tffA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.71A 2oqeD-1tffA:
undetectable		 2oqeD-1tffA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.72A 2oqeF-1tffA:
undetectable		 2oqeF-1tffA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.67A 2w0qA-1tffA:
undetectable		 2w0qA-1tffA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 HIS A 177
HIS A 205
HIS A 206
 None
 0.67A 2w0qB-1tffA:
undetectable		 2w0qB-1tffA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 10 TYR A  60
PHE A 102
LEU A  64
VAL A 109
LEU A  61
 None
 1.27A 2w98A-1tffA:
undetectable		 2w98A-1tffA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 12 PHE A 102
LEU A  64
PHE A  74
ILE A 189
ILE A 227
 None
 1.14A 3nxuB-1tffA:
undetectable		 3nxuB-1tffA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 ARG A  54
LYS A   7
LYS A  46
 None
 1.40A 4k50E-1tffA:
undetectable		 4k50E-1tffA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 12 HIS A  22
ASP A  21
ASP A  14
ILE A  15
ILE A  32
 None
 1.50A 4ktvA-1tffA:
0.0
4ktvB-1tffA:
0.0		 4ktvA-1tffA:
19.13
4ktvB-1tffA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 LYS A  44
ILE A  42
ILE A  15
 None
 0.69A 4y0qA-1tffA:
undetectable		 4y0qA-1tffA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 12 ASP A 124
ILE A 131
SER A 117
LEU A 108
VAL A 105
 None
 1.14A 5twjC-1tffA:
undetectable		 5twjC-1tffA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 12 ILE A 131
LEU A 118
SER A 117
LEU A 108
VAL A 105
 None
 1.17A 5twjC-1tffA:
undetectable		 5twjC-1tffA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 LEU A 191
ALA A 190
LEU A  56
 None
 0.47A 5uunB-1tffA:
undetectable		 5uunB-1tffA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		3 / 3 ARG A  43
ILE A   9
SER A  10
 None
 0.71A 5zw2A-1tffA:
undetectable		 5zw2A-1tffA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens) 		5 / 12 ASP A  14
ILE A  15
ILE A  32
HIS A  22
ASP A  21
 None
 1.49A 6fbpA-1tffA:
undetectable
6fbpB-1tffA:
undetectable		 6fbpA-1tffA:
13.25
6fbpB-1tffA:
13.25