SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 VAL A  39
VAL A  43
ILE A  59
LEU A 102
 None
 0.88A 1igxA-1tg6A:
undetectable		 1igxA-1tg6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 101
ALA A  72
ASP A  37
ASP A  36
PRO A 124
 None
 0.91A 3so9B-1tg6A:
undetectable		 3so9B-1tg6A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		4 / 5 HIS A 156
ALA A 104
GLN A  81
TYR A  77
 None
 1.25A 4gboA-1tg6A:
undetectable		 4gboA-1tg6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ALA A 154
VAL A 163
GLY A 183
ILE A 164
 None
 0.76A 4ll3A-1tg6A:
undetectable		 4ll3A-1tg6A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		5 / 10 ALA A 154
VAL A 163
GLY A 183
ILE A 184
ILE A 164
 None
 1.07A 4njuB-1tg6A:
undetectable		 4njuB-1tg6A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		5 / 10 ALA A 154
VAL A 163
GLY A 183
ILE A 184
ILE A 164
 None
 1.05A 4njuD-1tg6A:
undetectable		 4njuD-1tg6A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A  33
GLY A  67
SER A  97
LEU A 102
 None
 0.83A 5izfA-1tg6A:
undetectable		 5izfA-1tg6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens) 		4 / 5 HIS A 156
ALA A 104
GLN A  81
TYR A  77
 None
 1.26A 5uizA-1tg6A:
undetectable		 5uizA-1tg6A:
20.57