SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1th8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		5 / 8 ALA B  27
LEU B  22
LEU B  53
ILE B  64
VAL B  87
 None
 1.20A 2uxpA-1th8B:
undetectable		 2uxpA-1th8B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		5 / 10 LEU B  14
LEU B  18
LEU B  30
VAL B  34
ILE B  64
 None
 1.02A 2w9gA-1th8B:
undetectable		 2w9gA-1th8B:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		4 / 6 LEU B  18
GLY B  51
LEU B   3
SER B   2
 None
 0.68A 3aiaA-1th8B:
undetectable		 3aiaA-1th8B:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		5 / 11 LEU B  14
LEU B  18
LEU B  30
VAL B  34
ILE B  64
 None
 0.98A 3frbX-1th8B:
undetectable		 3frbX-1th8B:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		4 / 8 SER B  94
PHE B  91
VAL B  63
LEU B  22
 None
 0.91A 3jq7C-1th8B:
3.9		 3jq7C-1th8B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		5 / 8 VAL B  34
LEU B  30
ILE B  46
VAL B  16
LEU B  18
 None
 1.05A 3kp6A-1th8B:
undetectable
3kp6B-1th8B:
undetectable		 3kp6A-1th8B:
25.66
3kp6B-1th8B:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1th8 ANTI-SIGMA F FACTOR
ANTAGONIST
(Geobacillus
stearothermophil
us) 		4 / 7 ARG B  67
ALA B  27
ILE B   5
LEU B  18
 None
 0.96A 5te8C-1th8B:
undetectable		 5te8C-1th8B:
13.40