SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1thm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 LEU A 143
ALA A 182
ALA A 180
VAL A 147
LEU A 132
 None
None
NA  A 303 ( 4.1A)
None
None
 1.36A 1hbpA-1thmA:
undetectable		 1hbpA-1thmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		3 / 3 THR A 217
PRO A 214
THR A 215
 None
 0.84A 1ovfB-1thmA:
undetectable		 1ovfB-1thmA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 ALA A  32
ALA A  81
GLY A  91
THR A  92
ALA A  79
 None
 1.02A 2f16H-1thmA:
undetectable
2f16I-1thmA:
undetectable		 2f16H-1thmA:
23.13
2f16I-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 ALA A  32
ALA A  81
GLY A  91
THR A  92
ALA A  79
 None
 1.02A 2f16V-1thmA:
undetectable
2f16W-1thmA:
undetectable		 2f16V-1thmA:
23.13
2f16W-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 7 THR A   2
ALA A 273
TRP A  24
LEU A 237
 None
 1.17A 2hzqA-1thmA:
undetectable		 2hzqA-1thmA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 12 VAL A  52
SER A 216
THR A 215
GLY A  72
ALA A  76
 None
 1.22A 2x2iC-1thmA:
undetectable		 2x2iC-1thmA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 7 VAL A 234
ILE A  18
ALA A 204
GLY A 233
THR A  92
 None
 1.45A 2xrzB-1thmA:
undetectable		 2xrzB-1thmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 THR A  83
ALA A  81
GLY A  91
THR A  92
ALA A  93
 None
 1.26A 3mg0H-1thmA:
undetectable
3mg0I-1thmA:
undetectable		 3mg0H-1thmA:
23.13
3mg0I-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 ALA A  32
ALA A  81
GLY A  91
THR A  92
ALA A  79
 None
 1.05A 3mg0V-1thmA:
undetectable
3mg0W-1thmA:
undetectable		 3mg0V-1thmA:
23.13
3mg0W-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 9 ILE A  78
GLY A  77
VAL A 231
THR A  92
GLY A 233
 None
 1.39A 4acaB-1thmA:
3.3
4acaC-1thmA:
3.3		 4acaB-1thmA:
19.79
4acaC-1thmA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 6 ALA A 235
ALA A  93
PRO A  94
THR A  92
 None
 1.07A 4dtzB-1thmA:
undetectable		 4dtzB-1thmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 7 ALA A  96
ALA A 235
ALA A  79
THR A  92
 None
 0.81A 4du2B-1thmA:
0.0		 4du2B-1thmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 8 ALA A  96
GLY A  91
PRO A 229
ILE A  34
 None
 0.69A 4ll3A-1thmA:
undetectable		 4ll3A-1thmA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 7 ALA A  20
LEU A 237
LEU A 238
ILE A  18
 None
 0.68A 4ubsA-1thmA:
undetectable		 4ubsA-1thmA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 12 ALA A  93
THR A  92
GLY A  31
SER A 240
ALA A 239
 None
 1.15A 4ypmA-1thmA:
undetectable		 4ypmA-1thmA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 THR A  73
ALA A  76
GLY A  77
ALA A  81
ASP A   5
 None
None
None
None
CA  A 301 ( 3.3A)
 1.35A 5bxnV-1thmA:
undetectable
5bxnW-1thmA:
undetectable		 5bxnV-1thmA:
24.14
5bxnW-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 12 THR A  83
ALA A  81
GLY A  91
THR A  92
ALA A  93
 None
 1.22A 5cz7V-1thmA:
undetectable
5cz7W-1thmA:
undetectable		 5cz7V-1thmA:
24.48
5cz7W-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 6 ALA A 227
THR A 228
VAL A 231
VAL A 200
 None
 0.94A 5eclA-1thmA:
undetectable		 5eclA-1thmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 6 ALA A 227
THR A 228
VAL A 231
VAL A 200
 None
 0.82A 5eclD-1thmA:
undetectable		 5eclD-1thmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		4 / 6 ILE A 179
ALA A 227
THR A 228
VAL A 200
 None
 0.85A 5eclD-1thmA:
undetectable		 5eclD-1thmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 12 THR A  83
ALA A  81
GLY A  91
THR A  92
ALA A  93
 None
 1.20A 5l66H-1thmA:
undetectable
5l66I-1thmA:
undetectable		 5l66H-1thmA:
24.48
5l66I-1thmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 12 GLY A 135
ALA A 173
ILE A 179
ALA A 178
VAL A 181
 None
None
None
NA  A 303 ( 4.6A)
None
 1.00A 5n0tB-1thmA:
undetectable		 5n0tB-1thmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		3 / 3 GLN A  19
TYR A 274
ASN A 272
 None
 0.98A 6dwdC-1thmA:
undetectable		 6dwdC-1thmA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 12 ALA A  32
ALA A  81
GLY A  91
THR A  92
ALA A  79
 None
 1.02A 6hwdH-1thmA:
undetectable
6hwdI-1thmA:
undetectable		 6hwdH-1thmA:
17.89
6hwdI-1thmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1thm THERMITASE
(Thermoactinomyce
s
vulgaris) 		5 / 11 ALA A  32
ALA A  81
GLY A  91
THR A  92
ALA A  79
 None
 1.02A 6hwdV-1thmA:
undetectable		 6hwdV-1thmA:
17.89