SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ti8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 LEU A 177
PHE A 245
GLY A 181
PHE A 251
LEU A  67
 None
 1.33A 1brpA-1ti8A:
undetectable		 1brpA-1ti8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 PHE A 251
ILE A 130
LYS A 152
ALA A 253
 None
 1.26A 1hk2A-1ti8A:
undetectable		 1hk2A-1ti8A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 SER A 216
VAL A 214
ASP A 231
LYS A 101
 None
 1.24A 1hwiB-1ti8A:
undetectable		 1hwiB-1ti8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 SER A 216
VAL A 214
ASP A 231
LYS A 101
 None
 1.24A 1hwkA-1ti8A:
undetectable		 1hwkA-1ti8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 SER A 216
VAL A 214
ASP A 231
LYS A 101
 None
 1.21A 1hwkC-1ti8A:
undetectable		 1hwkC-1ti8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 SER A 216
VAL A 214
ASP A 231
LYS A 101
 None
 1.22A 1hwkD-1ti8A:
undetectable		 1hwkD-1ti8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.11A 1jhoA-1ti8A:
undetectable		 1jhoA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.07A 1jhrA-1ti8A:
undetectable		 1jhrA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.09A 1jhyA-1ti8A:
undetectable		 1jhyA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.08A 1l4nA-1ti8A:
undetectable		 1l4nA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.09A 1l5kA-1ti8A:
undetectable		 1l5kA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.08A 1l5lA-1ti8A:
undetectable		 1l5lA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.10A 1l5mA-1ti8A:
undetectable		 1l5mA-1ti8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 5 PHE A 245
LEU A 235
PHE A 125
MET A 123
 None
 1.22A 1wrkB-1ti8A:
undetectable		 1wrkB-1ti8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 5 PHE A 245
LEU A 235
PHE A 125
MET A 123
 None
 1.23A 1wrlC-1ti8A:
undetectable		 1wrlC-1ti8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 VAL A 272
ILE A 268
GLY A 267
ARG A 109
 None
 0.80A 3bjwF-1ti8A:
undetectable		 3bjwF-1ti8A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A 116
GLY A 263
ILE A 268
ASP A  85
LEU A  86
 None
 0.90A 3ihtA-1ti8A:
undetectable		 3ihtA-1ti8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 PHE A  82
SER A 265
SER A 115
 None
 0.96A 3ufgB-1ti8A:
undetectable		 3ufgB-1ti8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 5 ASP A  77
GLU A 150
GLY A  72
GLN A  75
 None
 1.42A 3w9tG-1ti8A:
0.0		 3w9tG-1ti8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.87A 4eq4A-1ti8A:
undetectable		 4eq4A-1ti8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.90A 4eqlA-1ti8A:
undetectable		 4eqlA-1ti8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.91A 4eqlB-1ti8A:
undetectable		 4eqlB-1ti8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 9 GLY A 116
LEU A 260
SER A 265
GLU A 114
ARG A 113
 None
 1.08A 4kqiA-1ti8A:
undetectable		 4kqiA-1ti8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.96A 4l39A-1ti8A:
undetectable		 4l39A-1ti8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.95A 4l39B-1ti8A:
undetectable		 4l39B-1ti8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ALA A 250
GLN A 226
GLY A 225
 None
 0.65A 4odoC-1ti8A:
undetectable		 4odoC-1ti8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 MET A 266
GLU A 278
GLY A 279
ILE A 289
ILE A 288
 None
 1.24A 4xucA-1ti8A:
undetectable		 4xucA-1ti8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 MET A 266
GLU A 278
GLY A 279
ILE A 289
ILE A 288
 None
 1.26A 4xudA-1ti8A:
undetectable		 4xudA-1ti8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1ti8 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 TYR A 148
PRO A  73
THR A  71
ILE A  70
 None
 0.94A 5mzrE-1ti8A:
undetectable		 5mzrE-1ti8A:
13.83