SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1tid ANTI-SIGMA F FACTOR
(Geobacillus
stearothermophil
us) 		5 / 9 ASN A  50
ASP A  81
ILE A  86
PRO A  87
THR A 130
 ATP  A 200 ( 2.8A)
ATP  A 200 (-4.0A)
ATP  A 200 (-4.2A)
None
ATP  A 200 (-3.4A)
 0.67A 1aj6A-1tidA:
6.4		 1aj6A-1tidA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1tid ANTI-SIGMA F FACTOR
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A  50
ASP A  81
ILE A  86
PRO A  87
THR A 130
 ATP  A 200 ( 2.8A)
ATP  A 200 (-4.0A)
ATP  A 200 (-4.2A)
None
ATP  A 200 (-3.4A)
 0.77A 1kijB-1tidA:
6.8		 1kijB-1tidA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1tid ANTI-SIGMA F FACTOR
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A 129
ASP A  81
ASN A 127
 None
ATP  A 200 (-4.0A)
None
 0.58A 1vq1A-1tidA:
undetectable		 1vq1A-1tidA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1tid ANTI-SIGMA F FACTOR
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A  44
ALA A  28
ILE A  70
VAL A  75
VAL A  68
 None
 1.10A 3me6A-1tidA:
undetectable		 3me6A-1tidA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1tid ANTI-SIGMA F FACTOR
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A  50
ASP A  81
ILE A  86
PRO A  87
THR A 130
 ATP  A 200 ( 2.8A)
ATP  A 200 (-4.0A)
ATP  A 200 (-4.2A)
None
ATP  A 200 (-3.4A)
 0.80A 4uroD-1tidA:
6.5		 4uroD-1tidA:
20.47