SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		4 / 6 VAL A 156
ILE A 142
TRP A  89
LEU A  31
 None
 0.98A 1j96A-1tieA:
undetectable		 1j96A-1tieA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		3 / 3 TYR A  17
GLN A  30
TRP A  23
 None
 1.00A 4kn2C-1tieA:
undetectable		 4kn2C-1tieA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		5 / 12 GLY A  13
ILE A 144
GLY A  27
PHE A 117
THR A  15
 None
 1.29A 5eslA-1tieA:
undetectable		 5eslA-1tieA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		4 / 8 LEU A 154
VAL A  43
VAL A  29
ILE A  75
 None
 0.73A 5y9mA-1tieA:
undetectable		 5y9mA-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		4 / 8 LEU A 154
VAL A 101
VAL A  43
ILE A  75
 None
 0.67A 5y9mA-1tieA:
undetectable		 5y9mA-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		4 / 8 LEU A 154
VAL A 101
VAL A  43
ILE A  75
 None
 0.67A 5y9mX-1tieA:
undetectable		 5y9mX-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1tie ERYTHRINA TRYPSIN
INHIBITOR
(Erythrina
caffra) 		5 / 9 LEU A 154
VAL A 101
VAL A  43
ILE A  56
ILE A  75
 None
 1.14A 5yf9X-1tieA:
undetectable		 5yf9X-1tieA:
20.96