SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A  90
LEU A 140
SER A 141
LEU A 163
ALA A 118
 None
 0.90A 2v3kA-1tigA:
undetectable		 2v3kA-1tigA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 132
GLY A 133
LEU A 137
LEU A 140
 None
 0.79A 2vctA-1tigA:
undetectable		 2vctA-1tigA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 132
GLY A 133
LEU A 137
LEU A 140
 None
 0.73A 2vctB-1tigA:
undetectable		 2vctB-1tigA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		5 / 12 CYH A 144
LEU A 110
ALA A 148
ALA A 118
ALA A 106
 None
 0.82A 4x1iB-1tigA:
undetectable		 4x1iB-1tigA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		5 / 12 CYH A 144
LEU A 110
ALA A 148
ALA A 118
ALA A 106
 None
 0.90A 4x20B-1tigA:
undetectable		 4x20B-1tigA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		5 / 12 CYH A 144
LEU A 110
ALA A 148
ALA A 118
ALA A 106
 None
 0.90A 5xiwB-1tigA:
undetectable		 5xiwB-1tigA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1tig TRANSLATION
INITIATION FACTOR 3
(Geobacillus
stearothermophil
us) 		4 / 4 PHE A  99
ASP A  98
LEU A 140
LYS A 102
 None
 1.44A 6awvA-1tigA:
undetectable		 6awvA-1tigA:
24.43