SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tii HEAT LABILE
ENTEROTOXIN TYPE IIB
(Escherichia
coli) 		4 / 6 GLY A 135
GLY A 136
GLU A 134
ILE A 133
 None
 0.98A 4fglD-1tiiA:
undetectable		 4fglD-1tiiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1tii HEAT LABILE
ENTEROTOXIN TYPE IIB
(Escherichia
coli) 		4 / 8 VAL A  95
LEU A  99
TYR A 102
THR C 201
 None
 0.89A 4ma7A-1tiiA:
undetectable		 4ma7A-1tiiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1tii HEAT LABILE
ENTEROTOXIN TYPE IIB
(Escherichia
coli) 		6 / 12 ILE A 122
GLY A 116
ALA A 113
THR A  60
ALA A  88
VAL A  86
 None
 1.44A 4nkxB-1tiiA:
undetectable		 4nkxB-1tiiA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1tii HEAT LABILE
ENTEROTOXIN TYPE IIB
(Escherichia
coli) 		6 / 12 PHE C 212
GLY A 116
ALA A 113
THR A  60
ALA A  88
VAL A  86
 None
 1.48A 4nkxB-1tiiC:
undetectable		 4nkxB-1tiiC:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1tii HEAT LABILE
ENTEROTOXIN TYPE IIB
(Escherichia
coli) 		5 / 12 LEU A  99
GLY A 100
GLU A 108
TYR A  40
LEU A  39
 None
 1.41A 5czyA-1tiiA:
0.0		 5czyA-1tiiA:
16.49