SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A  37
ALA A  38
LEU A   5
LEU A   4
LEU A 193
 None
 1.28A 1gwrA-1tj5A:
undetectable		 1gwrA-1tj5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 GLY A  56
VAL A  55
LEU A  51
LEU A  10
TYR A  39
 None
 1.28A 1pbcA-1tj5A:
undetectable		 1pbcA-1tj5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A  68
SER A 161
LEU A  85
HIS A  73
ALA A  40
 None
 1.43A 2a58A-1tj5A:
4.0
2a58E-1tj5A:
4.0		 2a58A-1tj5A:
20.08
2a58E-1tj5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 HIS A  73
ALA A  40
GLY A  68
SER A 161
LEU A  85
 None
 1.43A 2a58C-1tj5A:
4.0
2a58D-1tj5A:
3.3		 2a58C-1tj5A:
20.08
2a58D-1tj5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A 150
ASP A 153
SER A 149
SER A 187
 SUC  A 245 ( 4.6A)
SUC  A 245 ( 4.0A)
SUC  A 245 (-3.6A)
MG  A 247 (-2.6A)
 1.14A 2cmlA-1tj5A:
undetectable		 2cmlA-1tj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A  85
ARG A  91
TRP A  89
ILE A 117
 None
 1.35A 2cmlB-1tj5A:
undetectable		 2cmlB-1tj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A  85
ARG A  91
TRP A  89
ILE A 117
 None
 1.36A 2cmlC-1tj5A:
undetectable		 2cmlC-1tj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 SER A 150
ASP A 153
SER A 149
SER A 187
 SUC  A 245 ( 4.6A)
SUC  A 245 ( 4.0A)
SUC  A 245 (-3.6A)
MG  A 247 (-2.6A)
 1.06A 2cmlC-1tj5A:
undetectable		 2cmlC-1tj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A  64
GLN A 168
THR A 167
LEU A 157
 None
 1.22A 3ce6D-1tj5A:
4.2		 3ce6D-1tj5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 185
SER A 187
ASP A   9
ILE A   7
LEU A 193
 None
MG  A 247 (-2.6A)
PO4  A 246 (-2.1A)
None
None
 1.32A 3iv6B-1tj5A:
undetectable		 3iv6B-1tj5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASP A  99
VAL A 154
ILE A 130
TYR A 119
 None
 0.92A 3pglA-1tj5A:
7.5		 3pglA-1tj5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A  43
ASP A 190
ASP A 155
ILE A 147
 SUC  A 245 (-4.9A)
MG  A 247 (-2.9A)
SUC  A 245 (-2.8A)
None
 1.05A 4k0bA-1tj5A:
undetectable		 4k0bA-1tj5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A  43
ASP A 190
ASP A 155
ILE A 147
 SUC  A 245 (-4.9A)
MG  A 247 (-2.9A)
SUC  A 245 (-2.8A)
None
 1.06A 4l7iA-1tj5A:
undetectable		 4l7iA-1tj5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASP A 186
ASP A 190
ILE A 233
TYR A  39
 MG  A 248 ( 2.8A)
MG  A 247 (-2.9A)
None
None
 1.05A 4xjeA-1tj5A:
2.3		 4xjeA-1tj5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A  37
ALA A  38
LEU A   5
LEU A   4
LEU A 193
 None
 1.29A 5hyrB-1tj5A:
0.0		 5hyrB-1tj5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A  32
PRO A  60
TYR A  36
 None
 1.07A 5tzoB-1tj5A:
undetectable		 5tzoB-1tj5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 7 GLY A  68
LEU A  64
GLY A 164
LEU A 193
ILE A 233
 None
 1.18A 5vkqA-1tj5A:
undetectable
5vkqB-1tj5A:
undetectable		 5vkqA-1tj5A:
10.48
5vkqB-1tj5A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 8 GLY A  68
LEU A  64
GLY A 164
LEU A 193
ILE A 233
 None
 1.18A 5vkqB-1tj5A:
undetectable
5vkqC-1tj5A:
undetectable		 5vkqB-1tj5A:
10.48
5vkqC-1tj5A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 234
GLY A 231
GLN A  25
VAL A  55
VAL A  15
 None
 1.31A 6bxlB-1tj5A:
undetectable		 6bxlB-1tj5A:
20.10