SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 178
ILE A 211
ILE A 120
LEU A 236
 None
 0.96A 2xkwB-1tk1A:
undetectable		 2xkwB-1tk1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 136
CYH A 114
GLN A  15
ILE A  20
 None
 1.29A 2xz5A-1tk1A:
0.0
2xz5B-1tk1A:
0.0		 2xz5A-1tk1A:
20.65
2xz5B-1tk1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A  15
ILE A  20
TYR A 136
CYH A 114
 None
 1.25A 2xz5D-1tk1A:
0.0
2xz5E-1tk1A:
0.0		 2xz5D-1tk1A:
20.65
2xz5E-1tk1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.13A 3eeyE-1tk1A:
undetectable		 3eeyE-1tk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.11A 3eeyF-1tk1A:
undetectable		 3eeyF-1tk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.07A 3eeyJ-1tk1A:
undetectable		 3eeyJ-1tk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 212
ARG A 188
PHE A 213
TYR A 216
 None
 1.28A 4uciA-1tk1A:
0.0		 4uciA-1tk1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 212
ARG A 188
PHE A 213
TYR A 216
 None
 1.28A 4uciB-1tk1A:
0.0		 4uciB-1tk1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 235
ASP A 233
LEU A 185
 None
 0.69A 5uhbC-1tk1A:
2.4		 5uhbC-1tk1A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1tk1 COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 235
ASP A 233
LEU A 185
 None
 0.62A 5uhcC-1tk1A:
undetectable		 5uhcC-1tk1A:
12.05