SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
4 / 6 LEU A  64
VAL A 160
VAL A  31
ILE A 176
None
1.25A 2hyyB-1tk9A:
undetectable
2hyyB-1tk9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
4 / 4 LEU A 180
THR A 179
ILE A 117
HIS A 173
None
1.17A 2jfaB-1tk9A:
undetectable
2jfaB-1tk9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 10 ILE A  47
ILE A  45
GLY A  32
TYR A  68
LEU A 143
None
1.14A 3elzB-1tk9A:
undetectable
3elzB-1tk9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 10 ILE A  47
ILE A  45
GLY A  32
TYR A  68
LEU A 143
None
1.16A 3elzC-1tk9A:
undetectable
3elzC-1tk9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
6 / 12 ILE A  47
ALA A  62
PHE A  60
ILE A 184
LEU A  35
ILE A  45
None
1.50A 4fhbA-1tk9A:
undetectable
4fhbA-1tk9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
4 / 8 LEU A 180
CYH A 181
PHE A  60
TYR A  68
None
0.93A 4j7uD-1tk9A:
3.9
4j7uD-1tk9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 12 LEU A 141
ASP A  56
ILE A  47
VAL A 113
ILE A 115
None
0.74A 4q1xB-1tk9A:
undetectable
4q1xB-1tk9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 12 ILE A  47
ALA A  62
PHE A  60
ILE A 184
ILE A  45
None
1.06A 5e8qA-1tk9A:
2.4
5e8qA-1tk9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 12 LEU A 180
ILE A 177
LEU A  35
LEU A  39
LEU A  64
None
0.99A 5nfjA-1tk9A:
undetectable
5nfjA-1tk9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 8 VAL A  31
LEU A  35
ILE A  45
ILE A  47
SER A 144
None
0.96A 5numA-1tk9A:
undetectable
5numA-1tk9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 12 GLY A  49
LEU A  24
GLY A 145
SER A 120
ILE A 169
None
1.19A 5vooA-1tk9A:
undetectable
5vooA-1tk9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
5 / 12 GLY A  49
LEU A  24
GLY A 145
SER A 120
ILE A 169
None
1.17A 5vooC-1tk9A:
undetectable
5vooC-1tk9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni)
3 / 3 GLN A  19
ILE A 174
HIS A 178
None
0.68A 5z12B-1tk9A:
undetectable
5z12B-1tk9A:
19.58