SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 158
CYH A 159
SER A 165
LEU A 243
TYR A 207
 M6T  A 681 (-3.5A)
None
None
None
None
 1.24A 1fm6D-1tkcA:
0.4		 1fm6D-1tkcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 422
HIS A 419
ALA A 168
ILE A 424
 None
 0.82A 1gtnP-1tkcA:
undetectable
1gtnQ-1tkcA:
undetectable		 1gtnP-1tkcA:
7.54
1gtnQ-1tkcA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.80A 1jnoA-1tkcA:
undetectable		 1jnoA-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.80A 1jnoB-1tkcA:
undetectable		 1jnoB-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 646
SER A 527
SER A 564
ALA A 502
THR A 358
 None
 1.47A 1m4dA-1tkcA:
0.0		 1m4dA-1tkcA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.89A 1magA-1tkcA:
undetectable		 1magA-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.89A 1magB-1tkcA:
undetectable		 1magB-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.85A 1ng8A-1tkcA:
undetectable		 1ng8A-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.85A 1ng8B-1tkcA:
undetectable		 1ng8B-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.96A 1nrmA-1tkcA:
undetectable		 1nrmA-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.96A 1nrmB-1tkcA:
undetectable		 1nrmB-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.87A 1nruA-1tkcA:
undetectable		 1nruA-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 423
VAL A 453
TRP A 465
 None
 0.87A 1nruB-1tkcA:
undetectable		 1nruB-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 275
VAL A 262
TYR A 252
GLY A  32
 None
 0.99A 1s1xA-1tkcA:
undetectable		 1s1xA-1tkcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 565
GLU A 506
LEU A 526
 None
 0.75A 1v8bB-1tkcA:
undetectable		 1v8bB-1tkcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 243
ILE A 244
VAL A 217
LEU A 155
TRP A 212
 None
 1.31A 1wsvA-1tkcA:
0.0		 1wsvA-1tkcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 243
ILE A 244
VAL A 217
LEU A 155
TRP A 212
 None
 1.31A 1wsvB-1tkcA:
0.0		 1wsvB-1tkcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 202
THR A 242
TYR A 184
LEU A 155
 None
 1.00A 1z2bB-1tkcA:
undetectable		 1z2bB-1tkcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 333
LEU A 146
GLY A 432
ALA A 433
LEU A 334
 None
 1.11A 2aylA-1tkcA:
undetectable		 2aylA-1tkcA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 430
PHE A 431
ALA A 433
LEU A 135
 None
 0.75A 2bxmA-1tkcA:
3.8		 2bxmA-1tkcA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 175
ALA A 129
GLY A 427
ILE A 428
LEU A 171
 None
 0.91A 2o4nB-1tkcA:
undetectable		 2o4nB-1tkcA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 175
ILE A 424
ALA A 168
GLU A 112
LEU A 180
 None
 1.38A 2v0mA-1tkcA:
0.0		 2v0mA-1tkcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 175
LEU A 177
PHE A 397
ILE A 424
ALA A 168
 None
 1.21A 2v0mC-1tkcA:
0.0		 2v0mC-1tkcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 243
PRO A 241
ALA A 172
ALA A 125
 None
 0.91A 2vcvF-1tkcA:
undetectable		 2vcvF-1tkcA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 432
SER A 429
GLY A 427
GLY A 127
ALA A 433
 None
 0.90A 3douA-1tkcA:
undetectable		 3douA-1tkcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 414
ILE A 428
GLY A 379
LEU A 171
 None
 0.87A 3elzA-1tkcA:
undetectable		 3elzA-1tkcA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 660
VAL A 656
ILE A 557
LEU A 576
ALA A 583
 None
 1.14A 3kw2B-1tkcA:
undetectable		 3kw2B-1tkcA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 PRO A  31
SER A  24
SER A 254
LYS A 276
 None
 1.14A 3lsfH-1tkcA:
undetectable		 3lsfH-1tkcA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 417
VAL A 446
THR A 441
 None
 0.69A 3nduD-1tkcA:
undetectable		 3nduD-1tkcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 595
VAL A 560
ILE A 558
TYR A 626
 None
 0.99A 3pglA-1tkcA:
undetectable		 3pglA-1tkcA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 441
PHE A 442
ARG A 359
LEU A 388
 None
 1.12A 3qelC-1tkcA:
undetectable		 3qelC-1tkcA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  41
TYR A 297
LEU A  80
ILE A  17
HIS A 296
 None
 1.40A 3qt0A-1tkcA:
0.0		 3qt0A-1tkcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 417
VAL A 446
THR A 441
 None
 0.79A 3tl9A-1tkcA:
undetectable		 3tl9A-1tkcA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 171
ASN A 124
GLY A 427
ILE A 428
 None
 0.87A 3wxoA-1tkcA:
undetectable		 3wxoA-1tkcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 177
ASN A 124
GLY A 427
ILE A 428
 None
 0.83A 3wxoA-1tkcA:
undetectable		 3wxoA-1tkcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 224
GLY A 220
ILE A 244
VAL A 217
ALA A  38
 None
 1.03A 4a6dA-1tkcA:
3.2		 4a6dA-1tkcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 224
GLY A 220
ILE A 244
VAL A 217
PHE A 154
 None
 1.13A 4a6dA-1tkcA:
3.2		 4a6dA-1tkcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 224
GLY A 220
ILE A 244
VAL A 217
ALA A  38
 None
 1.02A 4a6eA-1tkcA:
2.9		 4a6eA-1tkcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 500
THR A 620
TRP A 623
 None
 1.21A 4d7hA-1tkcA:
0.4		 4d7hA-1tkcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 397
GLY A 127
LEU A 177
VAL A 126
 None
 0.92A 4dubB-1tkcA:
undetectable		 4dubB-1tkcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 158
CYH A 159
SER A 165
LEU A 243
TYR A 207
 M6T  A 681 (-3.5A)
None
None
None
None
 1.20A 4emaA-1tkcA:
0.0		 4emaA-1tkcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 676
VAL A 586
VAL A 610
TYR A 626
 None
 1.13A 4r7iA-1tkcA:
undetectable		 4r7iA-1tkcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 500
THR A 620
TRP A 623
 None
 1.18A 4ug5A-1tkcA:
0.0		 4ug5A-1tkcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 500
THR A 620
TRP A 623
 None
 1.14A 4uglA-1tkcA:
undetectable		 4uglA-1tkcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 230
ALA A 228
ILE A 231
ALA A  38
LEU A  44
 None
 1.21A 4v1fA-1tkcA:
undetectable
4v1fB-1tkcA:
undetectable		 4v1fA-1tkcA:
9.58
4v1fB-1tkcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 668
ILE A 664
ILE A 581
 None
 0.73A 4y0qA-1tkcA:
undetectable		 4y0qA-1tkcA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  12
ALA A  38
GLY A  36
GLY A 220
 None
 0.84A 5e26C-1tkcA:
undetectable
5e26D-1tkcA:
undetectable		 5e26C-1tkcA:
19.61
5e26D-1tkcA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 211
GLY A 178
GLY A 173
TRP A 212
ASP A  61
ILE A 181
 None
 1.27A 5e9qC-1tkcA:
undetectable		 5e9qC-1tkcA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 211
GLY A 178
GLY A 173
TRP A 212
ASP A  61
ILE A 181
 None
 1.29A 5eifC-1tkcA:
undetectable		 5eifC-1tkcA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 211
GLY A 178
GLY A 173
TRP A 212
ASP A  61
ILE A 181
 None
 1.36A 5eiwC-1tkcA:
undetectable		 5eiwC-1tkcA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 7 VAL A 446
SER A 447
ALA A 449
GLY A 451
VAL A 453
 None
 1.39A 5fpdB-1tkcA:
2.9		 5fpdB-1tkcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 500
THR A 620
TRP A 623
 None
 1.20A 5g6cA-1tkcA:
0.0		 5g6cA-1tkcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 420
THR A 384
GLY A 440
THR A 468
TYR A 438
 None
 1.21A 5hfjB-1tkcA:
undetectable		 5hfjB-1tkcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 420
THR A 384
GLY A 440
THR A 468
TYR A 438
 None
 1.23A 5hfjG-1tkcA:
undetectable		 5hfjG-1tkcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 420
THR A 384
GLY A 440
THR A 468
TYR A 438
 None
 1.30A 5hfjH-1tkcA:
undetectable		 5hfjH-1tkcA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 332
GLY A 409
SER A 408
ASP A 396
ARG A 390
 None
 1.23A 5hikA-1tkcA:
undetectable		 5hikA-1tkcA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 158
CYH A 159
SER A 165
LEU A 243
TYR A 207
 M6T  A 681 (-3.5A)
None
None
None
None
 1.19A 5ji0D-1tkcA:
undetectable		 5ji0D-1tkcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 446
ALA A 467
THR A 562
PRO A 483
LEU A 618
 None
 1.15A 5mm4B-1tkcA:
2.7		 5mm4B-1tkcA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 648
ARG A 635
ASP A 634
GLY A 632
 None
 1.06A 5mraA-1tkcA:
0.0
5mraB-1tkcA:
0.5		 5mraA-1tkcA:
14.52
5mraB-1tkcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 8 ILE A 231
LEU A  44
ILE A 181
ASN A 179
SER A 147
 None
 1.44A 5numA-1tkcA:
undetectable		 5numA-1tkcA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 211
GLY A 178
GLY A 173
TRP A 212
ASP A  61
ILE A 181
 None
 1.32A 5wz1B-1tkcA:
undetectable		 5wz1B-1tkcA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  16
VAL A  20
GLY A 251
TYR A 252
 None
 0.92A 5x80C-1tkcA:
undetectable
5x80D-1tkcA:
undetectable		 5x80C-1tkcA:
13.22
5x80D-1tkcA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 297
LEU A  80
ILE A  17
HIS A 296
LEU A 224
 None
 1.50A 5ycpA-1tkcA:
undetectable		 5ycpA-1tkcA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 7 PRO A  34
LEU A  35
PHE A  63
LEU A  73
 None
 1.14A 6aycA-1tkcA:
undetectable		 6aycA-1tkcA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 330
ALA A 433
SER A 147
ASN A  54
 None
 0.98A 6f88B-1tkcA:
undetectable		 6f88B-1tkcA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1tkc TRANSKETOLASE
(Saccharomyces
cerevisiae) 		4 / 6 MET A 613
ALA A 572
LEU A 576
ALA A 583
 None
 0.99A 6fosB-1tkcA:
undetectable		 6fosB-1tkcA:
8.89