SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ILE A  70
GLY A  67
PRO A 188
PHE A 192
 None
 0.86A 1oniG-1tkeA:
undetectable
1oniI-1tkeA:
undetectable		 1oniG-1tkeA:
21.76
1oniI-1tkeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 CYH A 193
HIS A 194
PHE A 196
 None
 1.09A 3cr4X-1tkeA:
undetectable		 3cr4X-1tkeA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 SER A 154
LEU A 172
ARG A 145
ILE A 159
 None
 1.06A 3ln1C-1tkeA:
0.0		 3ln1C-1tkeA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ALA A  24
ASP A  22
GLY A  38
ILE A  60
PRO A   7
 None
 1.18A 3s53B-1tkeA:
undetectable		 3s53B-1tkeA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLY A 101
THR A 221
ASN A 100
 None
 0.66A 3v4tD-1tkeA:
undetectable		 3v4tD-1tkeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  25
TYR A  14
ASP A  49
ASP A  46
GLY A  38
 None
 1.16A 4j7xF-1tkeA:
undetectable		 4j7xF-1tkeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 HIS A 194
GLU A 176
HIS A  81
LEU A  86
 None
 1.33A 4m2rA-1tkeA:
undetectable		 4m2rA-1tkeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 LEU A  31
ILE A  27
PRO A   7
LEU A  57
 None
 1.11A 5eb3A-1tkeA:
undetectable		 5eb3A-1tkeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 HIS A 175
HIS A  77
HIS A 186
 None
SER  A 500 (-4.0A)
None
 0.90A 5oexA-1tkeA:
undetectable		 5oexA-1tkeA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 TYR A 104
HIS A  77
MET A 181
 SER  A 500 (-4.2A)
SER  A 500 (-4.0A)
None
 1.24A 6af6A-1tkeA:
undetectable		 6af6A-1tkeA:
20.64