SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tkk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 9 ASN A 316
ILE A 281
PRO A 250
ALA A 272
ILE A 267
 None
 1.46A 1aj6A-1tkkA:
undetectable		 1aj6A-1tkkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ALA A 307
SER A  31
GLU A  47
THR A  51
ARG A  24
 None
None
None
None
GLU  A2471 (-3.8A)
 1.48A 1dy4A-1tkkA:
undetectable		 1dy4A-1tkkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 6 ALA A 228
LYS A 231
LYS A 232
ASP A 235
ALA A 236
 None
 0.90A 1iwhA-1tkkA:
undetectable		 1iwhA-1tkkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		4 / 7 ASP A 109
GLY A 303
ALA A 278
ILE A 275
 None
 0.63A 1n49A-1tkkA:
undetectable		 1n49A-1tkkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		4 / 7 ASP A 109
GLY A 303
ILE A 304
ILE A 275
 None
 0.76A 1n49A-1tkkA:
undetectable		 1n49A-1tkkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		4 / 6 ASP A 109
GLY A 303
ILE A 304
ILE A 275
 None
 0.78A 1n49D-1tkkA:
undetectable		 1n49D-1tkkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		3 / 3 LEU A  79
TYR A  38
GLY A  41
 None
 0.65A 2ocuA-1tkkA:
undetectable		 2ocuA-1tkkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		4 / 7 ALA A 278
ALA A 311
PHE A 320
PHE A 322
 None
 1.01A 2vcvL-1tkkA:
undetectable		 2vcvL-1tkkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		3 / 3 LEU A  75
ARG A   5
ILE A   3
 None
 0.55A 2xn5B-1tkkA:
undetectable		 2xn5B-1tkkA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A 244
GLU A 219
LYS A 160
LEU A  23
GLY A 195
 MG  A1601 ( 3.2A)
MG  A1601 (-2.9A)
GLU  A2471 (-2.6A)
None
None
 1.36A 2zj0B-1tkkA:
undetectable		 2zj0B-1tkkA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A 244
GLU A 219
LYS A 160
LEU A  23
GLY A 195
 MG  A1601 ( 3.2A)
MG  A1601 (-2.9A)
GLU  A2471 (-2.6A)
None
None
 1.41A 2zj0C-1tkkA:
undetectable		 2zj0C-1tkkA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A 244
GLU A 219
LYS A 160
LEU A  23
GLY A 195
 MG  A1601 ( 3.2A)
MG  A1601 (-2.9A)
GLU  A2471 (-2.6A)
None
None
 1.39A 3ce6B-1tkkA:
undetectable		 3ce6B-1tkkA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 9 ILE A 354
GLY A  44
ILE A  36
VAL A  32
ILE A  33
 None
 1.09A 3d1yB-1tkkA:
undetectable		 3d1yB-1tkkA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 GLY A 212
ILE A 178
ILE A 172
VAL A 218
ILE A 215
 None
 1.01A 3nduC-1tkkA:
undetectable		 3nduC-1tkkA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		4 / 8 GLY A 164
ASP A 166
ASP A 167
ILE A 175
 None
 0.68A 3so9A-1tkkA:
undetectable		 3so9A-1tkkA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		4 / 7 GLY A 164
ASP A 166
ASP A 167
ILE A 175
 None
 0.71A 3t3cA-1tkkA:
undetectable		 3t3cA-1tkkA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 GLY A 212
ILE A 178
ILE A 172
VAL A 218
ILE A 215
 None
 1.01A 3tkgC-1tkkA:
undetectable		 3tkgC-1tkkA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ILE A 304
ALA A 308
ALA A 311
ILE A 298
LEU A 326
 None
None
None
GLU  A2471 (-4.3A)
None
 1.13A 3uvvB-1tkkA:
undetectable		 3uvvB-1tkkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 11 ILE A 215
ALA A 204
ALA A 201
ILE A 241
VAL A 218
 None
 1.12A 4h1nA-1tkkA:
undetectable		 4h1nA-1tkkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 LEU A  23
LEU A 190
PRO A 221
ASP A 166
ASP A 167
 None
 1.37A 4j7xJ-1tkkA:
undetectable		 4j7xJ-1tkkA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 9 ALA A 106
GLY A 274
MET A 270
ILE A  66
VAL A  34
 None
 1.10A 4nptA-1tkkA:
undetectable		 4nptA-1tkkA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A 244
GLU A 219
LYS A 160
LEU A  23
GLY A 164
 MG  A1601 ( 3.2A)
MG  A1601 (-2.9A)
GLU  A2471 (-2.6A)
None
None
 1.34A 4pgfA-1tkkA:
undetectable		 4pgfA-1tkkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ASP A 244
GLU A 219
LYS A 160
LEU A  23
GLY A 195
 MG  A1601 ( 3.2A)
MG  A1601 (-2.9A)
GLU  A2471 (-2.6A)
None
None
 1.46A 4pgfA-1tkkA:
undetectable		 4pgfA-1tkkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 MET A 346
TYR A 120
ILE A 317
ALA A 278
ALA A 307
 None
 1.12A 5kvaB-1tkkA:
2.1		 5kvaB-1tkkA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		3 / 3 ASP A 244
ASN A 266
ASP A 321
 MG  A1601 ( 3.2A)
GLU  A2471 ( 4.7A)
ALA  A2470 (-2.7A)
 0.78A 5vopA-1tkkA:
6.7		 5vopA-1tkkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		3 / 3 ASP A 244
ASN A 266
ASP A 321
 MG  A1601 ( 3.2A)
GLU  A2471 ( 4.7A)
ALA  A2470 (-2.7A)
 0.73A 5vopB-1tkkA:
3.7		 5vopB-1tkkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 9 PHE A 156
ASP A 321
LEU A 188
VAL A 218
ASP A 191
 None
ALA  A2470 (-2.7A)
None
None
MG  A1601 ( 2.7A)
 1.45A 6c2mD-1tkkA:
undetectable		 6c2mD-1tkkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 ILE A 354
GLY A  44
ILE A  36
VAL A  32
ILE A  33
 None
 1.13A 6difA-1tkkA:
undetectable		 6difA-1tkkA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE
(Bacillus
subtilis) 		5 / 12 LEU A 188
GLY A 214
ILE A 161
VAL A 163
ILE A 175
 None
 0.98A 6emuA-1tkkA:
undetectable		 6emuA-1tkkA:
19.84