SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 283
PRO A 284
GLY A 285
ARG A  46
 None
 0.82A 1h4oB-1tklA:
undetectable		 1h4oB-1tklA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
 None
 1.28A 1h4oD-1tklA:
0.0		 1h4oD-1tklA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_F_BEZF1162_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
 None
 1.27A 1h4oF-1tklA:
0.0		 1h4oF-1tklA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
 None
 1.25A 1h4oH-1tklA:
0.5		 1h4oH-1tklA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 283
PRO A 284
GLY A 285
ARG A  46
 None
 0.89A 1oc3A-1tklA:
undetectable		 1oc3A-1tklA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_B_BEZB201_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
 None
 1.26A 1oc3B-1tklA:
0.0		 1oc3B-1tklA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 178
ALA A 234
GLY A 154
PHE A 170
 None
 0.79A 1sv9A-1tklA:
undetectable		 1sv9A-1tklA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
 None
 1.31A 1urmA-1tklA:
undetectable		 1urmA-1tklA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  53
GLU A  17
GLY A  51
THR A  43
VAL A  71
 None
 1.25A 1v3qE-1tklA:
undetectable		 1v3qE-1tklA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 238
ASP A 156
CYH A 193
 None
 0.94A 2br4E-1tklA:
undetectable		 2br4E-1tklA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 212
PHE A 197
GLY A 276
ASN A 270
 None
 0.85A 2qr2A-1tklA:
undetectable
2qr2B-1tklA:
undetectable		 2qr2A-1tklA:
19.94
2qr2B-1tklA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 178
ILE A 211
ILE A 120
LEU A 236
 None
 0.96A 2xkwB-1tklA:
undetectable		 2xkwB-1tklA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A  15
ILE A  20
TYR A 136
CYH A 114
 None
 1.29A 2xz5D-1tklA:
0.0
2xz5E-1tklA:
0.0		 2xz5D-1tklA:
18.48
2xz5E-1tklA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.08A 3eeyE-1tklA:
undetectable		 3eeyE-1tklA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.07A 3eeyF-1tklA:
undetectable		 3eeyF-1tklA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  30
ILE A 120
GLY A  67
LEU A 240
THR A  63
 None
 1.02A 3eeyJ-1tklA:
undetectable		 3eeyJ-1tklA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 259
PRO A 125
TYR A 161
PRO A 159
 None
 1.13A 3oyaA-1tklA:
0.0		 3oyaA-1tklA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 9 ARG A 245
ILE A 211
GLY A 209
ILE A 208
LEU A 169
 None
 1.11A 3u7sB-1tklA:
undetectable		 3u7sB-1tklA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 163
HIS A 126
ARG A 246
 None
 1.21A 4e7bC-1tklA:
undetectable		 4e7bC-1tklA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 212
PHE A 197
GLY A 276
ASN A 270
 None
 0.85A 4fgjA-1tklA:
undetectable
4fgjB-1tklA:
undetectable		 4fgjA-1tklA:
19.64
4fgjB-1tklA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 226
LEU A 225
GLU A 229
LEU A  19
 None
 1.37A 4k4yE-1tklA:
undetectable		 4k4yE-1tklA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 269
ARG A 135
GLY A 153
ASN A 133
ILE A 211
 None
 1.09A 4kotA-1tklA:
undetectable		 4kotA-1tklA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 212
PHE A 197
GLY A 276
ASN A 270
 None
 0.89A 4qoiA-1tklA:
undetectable
4qoiB-1tklA:
undetectable		 4qoiA-1tklA:
19.64
4qoiB-1tklA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 148
TRP A 149
ASP A 217
ASN A  92
 None
 1.05A 5b2oA-1tklA:
0.0		 5b2oA-1tklA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 148
TRP A 149
ASP A 217
ASN A  92
 None
 1.05A 5b2pA-1tklA:
1.2		 5b2pA-1tklA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1729_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 148
TRP A 149
ASP A 217
ASN A  92
 None
 1.06A 5b2qA-1tklA:
1.1		 5b2qA-1tklA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 131
SER A 117
ARG A 135
 None
 1.03A 5u63A-1tklA:
undetectable		 5u63A-1tklA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 235
ASP A 233
LEU A 185
 None
 0.68A 5uhbC-1tklA:
undetectable		 5uhbC-1tklA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 235
ASP A 233
LEU A 185
 None
 0.58A 5uhcC-1tklA:
undetectable		 5uhcC-1tklA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 164
TYR A 163
ARG A 246
 None
 0.70A 5uunA-1tklA:
0.0		 5uunA-1tklA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1tkl COPROPORPHYRINOGEN
III OXIDASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 164
TYR A 163
ARG A 246
 None
 0.53A 5uunB-1tklA:
0.0		 5uunB-1tklA:
21.53