SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		5 / 9 LEU A  81
ASP A  37
ILE A 125
GLY A 127
VAL A  77
 None
 1.17A 2r5qA-1tkpA:
undetectable		 2r5qA-1tkpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		5 / 9 LEU A  81
ASP A  37
ILE A 125
GLY A 127
VAL A  77
 None
 1.17A 2r5qC-1tkpA:
undetectable		 2r5qC-1tkpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_1
(HYPOTHETICAL PROTEIN)		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		4 / 4 GLU A  69
ASP A  62
ASP A 161
TYR A 169
 None
 1.46A 2yvlA-1tkpA:
undetectable		 2yvlA-1tkpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		4 / 6 ARG A  26
LEU A  88
MET A  22
ASP A  23
 None
 1.33A 4cevA-1tkpA:
undetectable
4cevB-1tkpA:
undetectable		 4cevA-1tkpA:
21.96
4cevB-1tkpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		4 / 6 MET A  22
ASP A  23
ARG A  26
LEU A  88
 None
 1.35A 4cevA-1tkpA:
undetectable
4cevC-1tkpA:
undetectable		 4cevA-1tkpA:
21.96
4cevC-1tkpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		4 / 6 ARG A  26
LEU A  88
MET A  22
ASP A  23
 None
 1.34A 4cevD-1tkpA:
undetectable
4cevE-1tkpA:
undetectable		 4cevD-1tkpA:
21.96
4cevE-1tkpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		4 / 6 ARG A  26
LEU A  88
MET A  22
ASP A  23
 None
 1.34A 4cevE-1tkpA:
undetectable
4cevF-1tkpA:
undetectable		 4cevE-1tkpA:
21.96
4cevF-1tkpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		3 / 3 ASP A  62
LEU A  63
PHE A  66
 None
 0.18A 4pthA-1tkpA:
undetectable		 4pthA-1tkpA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		4 / 8 LEU A  20
VAL A  31
LEU A  34
MET A 151
 None
 1.01A 4r38B-1tkpA:
undetectable		 4r38B-1tkpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN
(Halobacterium
salinarum) 		3 / 3 GLU A  56
HIS A  64
VAL A  55
 None
 0.89A 5trqB-1tkpA:
undetectable		 5trqB-1tkpA:
19.80