SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		4 / 8 ILE A 223
PHE A 196
LEU A   7
ARG A  31
 None
 0.86A 2azxA-1tl2A:
undetectable		 2azxA-1tl2A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		4 / 5 LEU A 109
ALA A 103
TRP A 122
LEU A 101
 None
 1.06A 2oaxA-1tl2A:
undetectable		 2oaxA-1tl2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		4 / 5 GLN A 199
PHE A 184
TRP A 216
GLY A 179
 None
None
None
NDG  A 241 (-4.7A)
 1.29A 2qmzA-1tl2A:
undetectable
2qmzB-1tl2A:
undetectable		 2qmzA-1tl2A:
24.06
2qmzB-1tl2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		5 / 12 LEU A   7
GLY A  18
LEU A 234
ALA A  32
GLY A 224
 None
None
None
None
NDG  A 238 (-3.2A)
 0.98A 2vmyB-1tl2A:
undetectable		 2vmyB-1tl2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		5 / 12 LEU A   7
GLY A  18
LEU A 234
ALA A  32
GLY A 224
 None
None
None
None
NDG  A 238 (-3.2A)
 0.94A 2vmyA-1tl2A:
undetectable		 2vmyA-1tl2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		5 / 12 LEU A  54
GLY A  65
LEU A  46
ALA A  79
GLY A  36
 None
None
None
None
NDG  A 237 (-3.0A)
 0.94A 2vmyA-1tl2A:
undetectable		 2vmyA-1tl2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		4 / 5 LEU A 109
GLY A 130
PHE A 137
ASN A 168
 None
NDG  A 239 (-3.0A)
None
NDG  A 239 (-3.5A)
 1.27A 3uq6B-1tl2A:
undetectable		 3uq6B-1tl2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		3 / 3 ARG A  31
ASP A  26
TYR A  20
 None
 0.80A 4yo9B-1tl2A:
undetectable		 4yo9B-1tl2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1tl2 PROTEIN
(TACHYLECTIN-2)
(Tachypleus
tridentatus) 		4 / 6 TYR A  11
ASP A  71
LEU A  34
GLY A  36
 None
None
None
NDG  A 237 (-3.0A)
 1.06A 5nooC-1tl2A:
undetectable		 5nooC-1tl2A:
16.98