SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 4 GLY A 399
ASP A 396
GLY A 439
THR A 415
 ONM  A 100 (-3.1A)
MN  A 582 (-2.7A)
ONM  A 100 (-3.6A)
None
 0.96A 1hxbB-1tl7A:
undetectable		 1hxbB-1tl7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		3 / 3 ALA A 456
HIS A 457
VAL A 460
 None
 0.46A 1lqtB-1tl7A:
undetectable		 1lqtB-1tl7A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		3 / 3 ALA A 456
HIS A 457
VAL A 460
 None
 0.45A 1lquB-1tl7A:
undetectable		 1lquB-1tl7A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 7 TYR A 443
THR A 529
THR A 532
VAL A 445
 FOK  A 101 (-4.4A)
None
None
None
 1.16A 1tv8B-1tl7A:
undetectable		 1tv8B-1tl7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 5 ALA A 514
TYR A 443
ILE A 392
ASP A 505
 None
FOK  A 101 (-4.4A)
None
FOK  A 101 ( 3.9A)
 1.13A 1upfA-1tl7A:
undetectable		 1upfA-1tl7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 8 SER A 508
PHE A 394
LEU A 554
SER A 489
 None
FOK  A 101 (-4.9A)
None
None
 1.03A 1wrlC-1tl7A:
undetectable
1wrlD-1tl7A:
undetectable		 1wrlC-1tl7A:
18.26
1wrlD-1tl7A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 6 ALA A 469
GLU A 468
ILE A 467
LEU A 426
 None
 1.02A 1xvaA-1tl7A:
undetectable
1xvaB-1tl7A:
undetectable		 1xvaA-1tl7A:
22.56
1xvaB-1tl7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 5 ASN A 389
ASN A 537
HIS A 457
ALA A 456
 None
 1.25A 3frqA-1tl7A:
1.5		 3frqA-1tl7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1tl7 ADENYLATE CYCLASE,
TYPE V
(Canis
lupus) 		4 / 7 ASN A 389
ASN A 537
HIS A 457
ALA A 456
 None
 1.25A 3frqB-1tl7A:
undetectable		 3frqB-1tl7A:
20.51