SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tlf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 6 LEU A 184
GLU A 217
ALA A 245
LEU A 243
 None
 1.08A 1etb1-1tlfA:
undetectable		 1etb1-1tlfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 12 ALA A 176
LEU A 177
PRO A 332
THR A 240
ILE A 210
 None
 1.15A 1mx8A-1tlfA:
undetectable		 1mx8A-1tlfA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 ILE A 289
ASP A 292
PHE A 293
 None
 0.53A 1uwjB-1tlfA:
undetectable		 1uwjB-1tlfA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 7 ASP A 275
VAL A 324
ASP A 292
ARG A 294
 None
 0.61A 2uyqA-1tlfA:
undetectable		 2uyqA-1tlfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 9 PHE A 147
LEU A 115
ALA A  67
LEU A 122
ALA A 145
 None
 1.08A 2vcvI-1tlfA:
1.8		 2vcvI-1tlfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  85
ARG A  86
GLN A  89
 None
 0.94A 2xnrA-1tlfA:
undetectable		 2xnrA-1tlfA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  85
GLU A 277
ASP A 247
 None
 0.58A 2zulA-1tlfA:
4.7		 2zulA-1tlfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 4 THR A 229
VAL A 264
GLY A 272
THR A 288
 None
 1.03A 3cflA-1tlfA:
undetectable		 3cflA-1tlfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  85
GLU A 277
ASP A 247
 None
 0.62A 3dmhA-1tlfA:
3.8		 3dmhA-1tlfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 ASP A 275
ASP A 292
ASP A 278
 None
 0.78A 3douA-1tlfA:
3.4		 3douA-1tlfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 10 ILE A 123
ILE A 124
VAL A 136
VAL A 119
LEU A 307
 None
 1.24A 3em0A-1tlfA:
undetectable		 3em0A-1tlfA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 7 LEU A 233
LEU A 262
SER A 269
THR A 334
 None
 0.90A 3lm8B-1tlfA:
4.7
3lm8D-1tlfA:
5.2		 3lm8B-1tlfA:
21.04
3lm8D-1tlfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 SER A 191
ASP A 149
ASN A 125
 IPT  A 998 ( 4.6A)
IPT  A 998 (-3.2A)
IPT  A 998 ( 4.7A)
 0.91A 3lsfB-1tlfA:
undetectable
3lsfE-1tlfA:
3.5		 3lsfB-1tlfA:
23.65
3lsfE-1tlfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 ASP A 149
ASN A 125
SER A 191
 IPT  A 998 (-3.2A)
IPT  A 998 ( 4.7A)
IPT  A 998 ( 4.6A)
 0.89A 3lsfB-1tlfA:
undetectable
3lsfE-1tlfA:
3.5		 3lsfB-1tlfA:
23.65
3lsfE-1tlfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 7 ASP A 247
GLY A 252
SER A 279
THR A 276
 None
 0.68A 4ac9C-1tlfA:
3.9		 4ac9C-1tlfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 8 VAL A 150
CYH A 107
ILE A 156
ILE A 124
 None
 1.02A 4afgD-1tlfA:
0.0
4afgE-1tlfA:
0.0		 4afgD-1tlfA:
22.33
4afgE-1tlfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 5 LEU A  90
ARG A  86
ILE A 123
ASN A 157
 None
 1.46A 4i00A-1tlfA:
undetectable		 4i00A-1tlfA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 6 VAL A  94
VAL A  66
ILE A 123
LEU A 305
 None
 0.91A 4l1wB-1tlfA:
undetectable		 4l1wB-1tlfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 7 VAL A  99
ALA A 106
LEU A 114
ASP A 149
LEU A 128
 None
None
None
IPT  A 998 (-3.2A)
None
 1.39A 4l9iA-1tlfA:
undetectable		 4l9iA-1tlfA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 324
THR A 288
ARG A 326
 None
 0.69A 5b2sB-1tlfA:
undetectable		 5b2sB-1tlfA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 VAL A 324
THR A 288
ARG A 326
 None
 0.71A 5b2tB-1tlfA:
undetectable		 5b2tB-1tlfA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 7 VAL A 244
LEU A 286
VAL A 264
THR A 328
 None
 0.99A 5e4dA-1tlfA:
undetectable
5e4dB-1tlfA:
undetectable		 5e4dA-1tlfA:
18.98
5e4dB-1tlfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 6 CYH A 140
LEU A 122
HIS A 112
LEU A 115
 None
 1.03A 5hpuC-1tlfA:
undetectable
5hpuD-1tlfA:
undetectable		 5hpuC-1tlfA:
4.83
5hpuD-1tlfA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 9 SER A 120
GLY A  65
ALA A  87
VAL A  94
ILE A 123
 None
 1.45A 5i3cA-1tlfA:
3.4		 5i3cA-1tlfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 8 ILE A 257
MET A 232
LEU A 174
ILE A 182
 None
 0.99A 5ieoA-1tlfA:
undetectable		 5ieoA-1tlfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 9 LEU A 177
GLY A 265
LEU A 330
THR A 287
VAL A 271
 None
 1.29A 6czmB-1tlfA:
1.0
6czmC-1tlfA:
0.5		 6czmB-1tlfA:
24.02
6czmC-1tlfA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 9 LEU A 177
GLY A 265
LEU A 330
THR A 287
VAL A 271
 None
 1.31A 6czmD-1tlfA:
undetectable
6czmE-1tlfA:
undetectable		 6czmD-1tlfA:
24.02
6czmE-1tlfA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 8 ASN A 125
GLN A 291
PRO A  76
ILE A  79
 IPT  A 998 ( 4.7A)
IPT  A 998 ( 4.7A)
IPT  A 998 (-3.8A)
None
 0.95A 6hzpA-1tlfA:
undetectable		 6hzpA-1tlfA:
20.52