SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tlj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622
(Sulfolobus
solfataricus) 		4 / 6 ILE A 117
GLU A 112
ARG A  41
ASP A  43
 None
 1.04A 1mt1B-1tljA:
undetectable
1mt1C-1tljA:
undetectable		 1mt1B-1tljA:
18.60
1mt1C-1tljA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622
(Sulfolobus
solfataricus) 		4 / 6 PHE A  33
MET A 184
LEU A  31
LEU A  34
 None
 1.22A 5dzke-1tljA:
undetectable
5dzks-1tljA:
undetectable		 5dzke-1tljA:
19.92
5dzks-1tljA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622
(Sulfolobus
solfataricus) 		3 / 3 HIS A  75
SER A  51
LYS A 181
 SO4  A 502 (-3.8A)
None
None
 1.32A 5os7A-1tljA:
undetectable		 5os7A-1tljA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622
(Sulfolobus
solfataricus) 		3 / 3 TRP A  96
GLU A  60
GLU A 155
 None
 1.03A 6fhwA-1tljA:
undetectable		 6fhwA-1tljA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622
(Sulfolobus
solfataricus) 		3 / 3 HIS A  75
SER A  51
LYS A 181
 SO4  A 502 (-3.8A)
None
None
 1.32A 6gmdB-1tljA:
undetectable		 6gmdB-1tljA:
20.11