SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 7 THR A 763
THR A 808
GLY A 885
TYR A 889
 FMN  A1451 (-3.1A)
FMN  A1451 (-4.0A)
FMN  A1451 (-3.1A)
FMN  A1451 (-3.7A)
 0.69A 1bu5A-1tllA:
18.1		 1bu5A-1tllA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 THR A 763
THR A 808
GLY A 885
TYR A 889
 FMN  A1451 (-3.1A)
FMN  A1451 (-4.0A)
FMN  A1451 (-3.1A)
FMN  A1451 (-3.7A)
 0.64A 1bu5B-1tllA:
18.2		 1bu5B-1tllA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 GLY A1204
GLU A1148
TYR A1402
HIS A1207
 None
 1.10A 1maaD-1tllA:
undetectable		 1maaD-1tllA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 7 ASP A1289
PHE A1281
SER A1313
ARG A1314
 NAP  A1453 ( 4.5A)
None
NAP  A1453 (-2.3A)
NAP  A1453 (-4.0A)
 1.36A 1rqpB-1tllA:
3.1		 1rqpB-1tllA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 6 LEU A1109
PHE A1112
ALA A1113
LEU A1128
 None
 0.95A 1ukbA-1tllA:
3.0		 1ukbA-1tllA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 ARG A1010
GLY A1250
PRO A1249
 NAP  A1453 (-2.9A)
NAP  A1453 (-3.6A)
NAP  A1453 (-4.2A)
 0.70A 2hreD-1tllA:
0.9		 2hreD-1tllA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 6 ARG A1407
THR A1353
ASN A 811
ASP A 813
 None
NAP  A1453 ( 4.4A)
None
None
 1.27A 2okcA-1tllA:
2.3		 2okcA-1tllA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 7 ASP A1289
PHE A1281
SER A1313
ARG A1314
 NAP  A1453 ( 4.5A)
None
NAP  A1453 (-2.3A)
NAP  A1453 (-4.0A)
 1.34A 2v7uB-1tllA:
3.2		 2v7uB-1tllA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 SER A1412
GLU A1136
ASP A 918
 None
 0.58A 2zthA-1tllA:
6.3		 2zthA-1tllA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 PRO A1106
LEU A1109
ARG A1124
 None
 0.88A 3aqiA-1tllA:
2.5		 3aqiA-1tllA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 SER A1412
GLU A1136
ASP A 918
 None
 0.78A 3bwmA-1tllA:
5.6		 3bwmA-1tllA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 SER A1412
GLU A1136
ASP A 918
 None
 0.67A 3bwyA-1tllA:
5.7		 3bwyA-1tllA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 GLY A1248
GLY A1252
LEU A1246
VAL A1358
GLN A1324
 None
None
None
None
NAP  A1453 (-2.6A)
 1.28A 3fzgA-1tllA:
2.8		 3fzgA-1tllA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 GLY A1350
GLY A1252
LEU A1399
MET A1354
VAL A1358
 None
None
NAP  A1453 (-3.8A)
None
None
 1.17A 3fzgA-1tllA:
2.8		 3fzgA-1tllA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 PRO A1255
SER A1176
GLY A1248
PRO A1249
 None
FAD  A1452 (-3.7A)
None
NAP  A1453 (-4.2A)
 0.69A 3hcrA-1tllA:
4.1		 3hcrA-1tllA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 ILE A1048
ALA A1054
LEU A 971
ARG A1084
LEU A1098
 None
 1.07A 3ix9B-1tllA:
2.7		 3ix9B-1tllA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 7 SER A1180
LEU A 998
ARG A1257
ILE A1177
 None
 1.03A 3ln1C-1tllA:
undetectable		 3ln1C-1tllA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 GLU A1295
GLN A1001
ARG A1257
PHE A1014
 None
 0.97A 3mjrD-1tllA:
3.3		 3mjrD-1tllA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 GLY A1250
GLY A1282
VAL A1247
ALA A1254
SER A1313
 NAP  A1453 (-3.6A)
None
None
FAD  A1452 (-3.6A)
NAP  A1453 (-2.3A)
 1.11A 3mteA-1tllA:
2.5		 3mteA-1tllA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 GLY A1250
GLY A1282
VAL A1247
ALA A1254
SER A1313
 NAP  A1453 (-3.6A)
None
None
FAD  A1452 (-3.6A)
NAP  A1453 (-2.3A)
 1.05A 3p2kD-1tllA:
3.8		 3p2kD-1tllA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 VAL A 899
ASP A 900
LEU A 903
LEU A 803
 None
 0.79A 3roxA-1tllA:
4.2		 3roxA-1tllA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 7 PRO A1249
GLY A1350
ALA A1356
ASP A1357
 NAP  A1453 (-4.2A)
None
None
NAP  A1453 ( 4.7A)
 0.81A 3ur0B-1tllA:
undetectable		 3ur0B-1tllA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 6 LEU A1384
ARG A1364
MET A1366
THR A1367
 None
 1.17A 3wg7A-1tllA:
0.0
3wg7J-1tllA:
undetectable		 3wg7A-1tllA:
19.23
3wg7J-1tllA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 11 LEU A 997
ALA A 995
VAL A1188
GLY A1034
VAL A1015
 None
 0.91A 4dqhA-1tllA:
undetectable		 4dqhA-1tllA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 ARG A1173
TRP A1214
GLY A1038
 FAD  A1452 (-3.9A)
None
None
 1.03A 4e7cA-1tllA:
undetectable		 4e7cA-1tllA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 LEU A1359
VAL A1335
LEU A1339
ILE A1346
 None
 0.81A 4r38D-1tllA:
undetectable		 4r38D-1tllA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 VAL A1188
LEU A1190
VAL A1035
GLY A1034
LEU A1025
 None
 1.15A 4rrwA-1tllA:
1.0		 4rrwA-1tllA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 VAL A1188
LEU A1190
VAL A1035
GLY A1034
LEU A1025
 None
 1.15A 4rrzA-1tllA:
1.0		 4rrzA-1tllA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 SER A1412
GLU A1136
ASP A 918
 None
 0.74A 4xudA-1tllA:
5.5		 4xudA-1tllA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 GLU A 789
LYS A 820
ASN A 817
 None
 1.01A 4y1dA-1tllA:
undetectable
4y1dD-1tllA:
undetectable		 4y1dA-1tllA:
13.05
4y1dD-1tllA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 5 THR A 981
THR A1019
HIS A1189
LEU A1033
 None
 1.30A 5axaC-1tllA:
3.5		 5axaC-1tllA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 GLY A1282
TYR A1322
LEU A1279
GLY A1252
ILE A1253
 None
NAP  A1453 (-3.5A)
None
None
None
 1.02A 5d4uD-1tllA:
undetectable		 5d4uD-1tllA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 GLY A1030
TYR A 841
GLY A 822
GLY A 818
HIS A1032
 None
None
None
None
FAD  A1452 (-3.5A)
 1.08A 5eqbA-1tllA:
undetectable		 5eqbA-1tllA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 6 HIS A1391
CYH A1244
HIS A1235
LEU A1236
 None
 1.33A 5hrqD-1tllA:
undetectable
5hrqG-1tllA:
undetectable
5hrqH-1tllA:
undetectable		 5hrqD-1tllA:
7.35
5hrqG-1tllA:
2.34
5hrqH-1tllA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 6 HIS A1391
CYH A1244
HIS A1235
LEU A1236
 None
 1.35A 5hrqH-1tllA:
undetectable
5hrqK-1tllA:
undetectable
5hrqL-1tllA:
undetectable		 5hrqH-1tllA:
7.35
5hrqK-1tllA:
2.34
5hrqL-1tllA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 TYR A1175
VAL A1195
ILE A1194
ILE A1218
 FAD  A1452 (-4.4A)
NAP  A1453 (-3.6A)
None
None
 0.79A 5hw8H-1tllA:
undetectable		 5hw8H-1tllA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 PHE A 821
VAL A 802
ILE A 793
LEU A 825
LEU A 906
 None
 1.11A 5im2A-1tllA:
0.0		 5im2A-1tllA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 11 ILE A1156
PHE A1112
VAL A1147
MET A1146
LEU A1163
 None
 1.20A 5jkwA-1tllA:
undetectable		 5jkwA-1tllA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 12 ALA A1054
MET A1158
ILE A1100
LEU A1150
LEU A1164
 None
 0.96A 5toaA-1tllA:
undetectable		 5toaA-1tllA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 8 VAL A1061
LEU A1164
THR A1161
ALA A1160
 None
 0.88A 5tt3H-1tllA:
undetectable		 5tt3H-1tllA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		6 / 9 SER A1176
THR A1251
GLY A1252
ALA A1254
CYH A1349
GLY A1350
 FAD  A1452 (-3.7A)
NAP  A1453 ( 3.4A)
None
FAD  A1452 (-3.6A)
None
None
 0.57A 5vw4A-1tllA:
29.1		 5vw4A-1tllA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		5 / 8 SER A1176
THR A1251
GLY A1252
CYH A1349
GLY A1350
 FAD  A1452 (-3.7A)
NAP  A1453 ( 3.4A)
None
None
None
 0.53A 5vw5A-1tllA:
28.9		 5vw5A-1tllA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		6 / 8 SER A1176
THR A1251
GLY A1252
ALA A1254
CYH A1349
GLY A1350
 FAD  A1452 (-3.7A)
NAP  A1453 ( 3.4A)
None
FAD  A1452 (-3.6A)
None
None
 0.58A 5vw9A-1tllA:
29.4		 5vw9A-1tllA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 4 TYR A1175
GLY A1038
ASN A1039
ARG A1173
 FAD  A1452 (-4.4A)
None
None
FAD  A1452 (-3.9A)
 1.41A 5w7bA-1tllA:
0.0
5w7bC-1tllA:
0.6		 5w7bA-1tllA:
8.83
5w7bC-1tllA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 LEU A1359
ASN A1388
LEU A1339
 None
 0.70A 6exiA-1tllA:
4.3		 6exiA-1tllA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		4 / 6 ILE A1177
TYR A1027
ARG A1257
SER A1258
 None
 1.27A 6f6jA-1tllA:
undetectable		 6f6jA-1tllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 1tll NITRIC-OXIDE
SYNTHASE, BRAIN
(Rattus
norvegicus) 		3 / 3 ILE A1090
THR A1089
PRO A1055
 None
 0.52A 6ncsA-1tllA:
undetectable		 6ncsA-1tllA:
18.29