SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tlq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		5 / 12 ALA A 149
LEU A 150
LEU A 104
ILE A  98
LEU A  19
 None
 1.05A 1errB-1tlqA:
undetectable		 1errB-1tlqA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		3 / 3 LEU A  85
PRO A  84
LEU A  88
 None
 0.54A 1hrkA-1tlqA:
undetectable		 1hrkA-1tlqA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		5 / 8 MET A   8
LEU A 150
ILE A 106
THR A  15
LEU A  57
 None
 1.38A 2xfhA-1tlqA:
undetectable		 2xfhA-1tlqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		3 / 3 PRO A  45
LEU A  46
GLN A  34
 None
 0.65A 3hznG-1tlqA:
undetectable
3hznH-1tlqA:
undetectable		 3hznG-1tlqA:
19.49
3hznH-1tlqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		5 / 8 VAL A 147
LEU A 150
VAL A  24
ARG A  22
LEU A  19
 None
 1.30A 3kp6A-1tlqA:
0.2
3kp6B-1tlqA:
undetectable		 3kp6A-1tlqA:
20.62
3kp6B-1tlqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		6 / 12 ALA A 152
GLY A 114
GLY A 119
ASP A 122
LEU A 121
ALA A 154
 None
 1.36A 3ou6A-1tlqA:
undetectable		 3ou6A-1tlqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		4 / 7 ASP A  99
ASP A 133
GLU A  93
ASP A 144
 CA  A 190 (-2.3A)
None
None
None
 1.19A 4fevB-1tlqA:
undetectable		 4fevB-1tlqA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		6 / 11 LEU A 132
ASP A 133
ILE A 128
GLY A 127
LEU A 143
VAL A 147
 None
 1.44A 5twjD-1tlqA:
undetectable		 5twjD-1tlqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 1tlq HYPOTHETICAL PROTEIN
YPJQ
(Bacillus
subtilis) 		5 / 12 GLN A  74
ASP A  92
LEU A  70
PRO A 103
ILE A 146
 None
 1.44A 6ccvC-1tlqA:
undetectable		 6ccvC-1tlqA:
10.22