SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 8 GLY A   9
LEU A  33
VAL A  24
PHE A 275
 None
 1.09A 1gsfA-1tltA:
undetectable		 1gsfA-1tltA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 8 GLY A   9
LEU A  33
VAL A  24
PHE A 275
 None
 1.09A 1gsfB-1tltA:
undetectable		 1gsfB-1tltA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 8 GLY A   9
LEU A  33
VAL A  24
PHE A 275
 None
 1.09A 1gsfD-1tltA:
undetectable		 1gsfD-1tltA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 7 TRP A 176
LEU A 130
GLY A 132
LEU A 177
 None
 1.03A 1gtiE-1tltA:
undetectable		 1gtiE-1tltA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 6 LEU A 168
ASP A 172
LEU A 175
ARG A 126
 None
 0.96A 1mt1A-1tltA:
undetectable
1mt1F-1tltA:
undetectable		 1mt1A-1tltA:
10.06
1mt1F-1tltA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 6 ARG A 126
LEU A 168
ASP A 172
LEU A 175
 None
 0.93A 1mt1B-1tltA:
undetectable
1mt1C-1tltA:
0.0		 1mt1B-1tltA:
16.51
1mt1C-1tltA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 5 ARG A 126
LEU A 168
ASP A 172
LEU A 175
 None
 0.96A 1n13B-1tltA:
undetectable
1n13C-1tltA:
0.0		 1n13B-1tltA:
16.51
1n13C-1tltA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 7 LEU A 168
ASP A 172
LEU A 175
ARG A 126
 None
 0.99A 1n13I-1tltA:
undetectable
1n13L-1tltA:
undetectable		 1n13I-1tltA:
10.06
1n13L-1tltA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		3 / 3 PHE A  70
ARG A 266
ASN A 124
 None
SO4  A 321 (-3.6A)
SO4  A 321 (-3.0A)
 0.89A 1xzxX-1tltA:
undetectable		 1xzxX-1tltA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A  85
VAL A  90
GLY A  89
LEU A  59
ALA A  63
 None
 0.80A 2egvA-1tltA:
4.6		 2egvA-1tltA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		3 / 3 LEU A  45
TYR A  55
GLY A  35
 None
 0.58A 2ocuA-1tltA:
undetectable		 2ocuA-1tltA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 7 ARG A 126
LEU A 168
ASP A 172
LEU A 175
 None
 0.98A 2qqcB-1tltA:
undetectable
2qqcC-1tltA:
undetectable		 2qqcB-1tltA:
16.82
2qqcC-1tltA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 7 LEU A 168
ASP A 172
LEU A 175
GLN A 296
ARG A 126
 None
 1.27A 2qqcA-1tltA:
undetectable
2qqcF-1tltA:
undetectable		 2qqcA-1tltA:
13.08
2qqcF-1tltA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 7 ARG A 126
LEU A 168
ASP A 172
LEU A 175
 None
 0.94A 2qqcD-1tltA:
undetectable
2qqcE-1tltA:
undetectable		 2qqcD-1tltA:
16.82
2qqcE-1tltA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 7 LEU A 168
ASP A 172
LEU A 175
GLN A 296
ARG A 126
 None
 1.29A 2qqcG-1tltA:
undetectable
2qqcJ-1tltA:
undetectable		 2qqcG-1tltA:
13.08
2qqcJ-1tltA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 7 LEU A 168
ASP A 172
LEU A 175
ARG A 126
 None
 0.97A 2qqcI-1tltA:
undetectable
2qqcL-1tltA:
undetectable		 2qqcI-1tltA:
13.08
2qqcL-1tltA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 7 LEU A 168
ASP A 172
LEU A 175
ARG A 126
 None
 0.98A 2qqdA-1tltA:
undetectable
2qqdE-1tltA:
undetectable		 2qqdA-1tltA:
13.08
2qqdE-1tltA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 10 LEU A  85
VAL A  90
GLY A  89
LEU A  59
ALA A  63
 None
 0.87A 2v3kA-1tltA:
undetectable		 2v3kA-1tltA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		3 / 3 ARG A 125
PRO A  97
PHE A 123
 SO4  A 321 (-3.1A)
None
None
 0.81A 3thrC-1tltA:
4.2		 3thrC-1tltA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 4 LEU A  33
ILE A 276
GLY A   9
PHE A  70
 None
 1.09A 4dc3A-1tltA:
5.8		 4dc3A-1tltA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 PHE A  70
ILE A   8
LEU A  62
GLY A  35
ALA A  64
 None
 1.18A 4eb4A-1tltA:
undetectable		 4eb4A-1tltA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 PHE A  70
ILE A   8
LEU A  62
GLY A  35
ALA A  64
 None
 1.21A 4eb4B-1tltA:
undetectable		 4eb4B-1tltA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A  59
ALA A  56
LEU A  85
GLY A  12
VAL A  69
 None
 0.97A 4nkvB-1tltA:
undetectable		 4nkvB-1tltA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 9 ALA A  36
ILE A  16
GLY A  14
SER A  50
ILE A  53
 None
 1.10A 4r21B-1tltA:
0.0		 4r21B-1tltA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  98
ALA A  99
LEU A 102
ALA A 292
 None
 1.18A 4x1kA-1tltA:
undetectable
4x1kB-1tltA:
undetectable		 4x1kA-1tltA:
21.48
4x1kB-1tltA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  98
ALA A  99
LEU A 102
ALA A 292
 None
 1.05A 4x20B-1tltA:
4.2		 4x20B-1tltA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A 168
PHE A 161
GLU A 100
PRO A  97
GLY A  12
 None
SO4  A 322 (-4.6A)
None
None
None
 1.17A 4ydqA-1tltA:
3.7		 4ydqA-1tltA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 8 VAL A  81
LEU A  59
GLY A  12
SER A  73
 None
 0.74A 5f1aA-1tltA:
undetectable		 5f1aA-1tltA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 11 ILE A   8
GLY A   9
ALA A  68
LEU A   6
VAL A 279
 None
 1.19A 5hw4B-1tltA:
undetectable		 5hw4B-1tltA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		4 / 5 TYR A 167
VAL A 299
PRO A  97
ALA A 295
 None
 1.07A 5otrA-1tltA:
undetectable		 5otrA-1tltA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A 168
PHE A 161
GLU A 100
PRO A  97
GLY A  12
 None
SO4  A 322 (-4.6A)
None
None
None
 1.22A 5xiqA-1tltA:
3.1		 5xiqA-1tltA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		5 / 12 LEU A 168
PHE A 161
GLU A 100
PRO A  97
GLY A  12
 None
SO4  A 322 (-4.6A)
None
None
None
 1.23A 5xiqD-1tltA:
2.9		 5xiqD-1tltA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)
(Escherichia
coli) 		3 / 3 ASN A 101
VAL A  94
HIS A  78
 None
 0.51A 6a5yD-1tltA:
undetectable		 6a5yD-1tltA:
15.98