SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		5 / 12 GLY A 261
GLY A 263
GLN A 241
ASP A 238
SER A 259
 None
 1.04A 1wg8A-1tlyA:
undetectable		 1wg8A-1tlyA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		5 / 12 GLY A 261
GLY A 263
GLN A 241
ASP A 238
SER A 259
 None
 1.16A 1wg8B-1tlyA:
undetectable		 1wg8B-1tlyA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		5 / 12 ILE A 206
ASN A 204
ALA A 202
LEU A 195
ASP A 238
 None
 1.14A 3ckkA-1tlyA:
undetectable		 3ckkA-1tlyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		4 / 7 SER A  85
GLY A 128
THR A 129
THR A  90
 None
 0.79A 4ac9C-1tlyA:
undetectable		 4ac9C-1tlyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		4 / 7 SER A  85
GLY A 128
THR A 129
THR A  90
 None
 0.78A 4acaC-1tlyA:
undetectable		 4acaC-1tlyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		3 / 3 PHE A  50
TYR A  53
TYR A  51
 None
 1.07A 4ffwA-1tlyA:
undetectable		 4ffwA-1tlyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		4 / 6 GLU A  79
TYR A  39
GLU A  38
GLU A  40
 None
 1.40A 4mi4A-1tlyA:
undetectable		 4mi4A-1tlyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		4 / 8 HIS A 218
VAL A 232
ALA A 215
TRP A 262
 None
 0.88A 5tt3H-1tlyA:
undetectable		 5tt3H-1tlyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		3 / 3 PHE A  48
ASP A  46
LEU A  94
 None
 0.68A 5uhbC-1tlyA:
1.7		 5uhbC-1tlyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		3 / 3 PHE A  48
ASP A  46
LEU A  94
 None
 0.76A 5uhcC-1tlyA:
undetectable		 5uhcC-1tlyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX
(Escherichia
coli) 		5 / 10 GLY A 264
TYR A 265
GLU A  81
TYR A  53
GLU A  38
 None
 1.50A 6cgdA-1tlyA:
0.1		 6cgdA-1tlyA:
16.97