SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		4 / 6 ASN A  63
TYR A   7
TYR A 171
TYR A  59
 None
 1.48A 1kiaA-1tmcA:
0.0		 1kiaA-1tmcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		4 / 6 ASN A  63
TYR A   7
TYR A 171
TYR A  59
 None
 1.50A 1kiaB-1tmcA:
0.0		 1kiaB-1tmcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		4 / 7 ASN A  63
TYR A   7
TYR A 171
TYR A  59
 None
 1.48A 1kiaC-1tmcA:
0.2		 1kiaC-1tmcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		4 / 7 ASN A  63
TYR A   7
TYR A 171
TYR A  59
 None
 1.48A 1kiaD-1tmcA:
undetectable		 1kiaD-1tmcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		3 / 3 ASP A 122
THR A 134
GLU A 128
 None
 0.82A 1pj7A-1tmcA:
undetectable		 1pj7A-1tmcA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zm8A-1tmcA:
undetectable		 2zm8A-1tmcA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.01A 2zmaA-1tmcA:
undetectable		 2zmaA-1tmcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		3 / 3 ARG A 114
ASP A 137
GLN A  87
 None
 0.87A 3lcvB-1tmcA:
undetectable		 3lcvB-1tmcA:
18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		6 / 10 TYR A   9
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.49A 3uprA-1tmcA:
28.1		 3uprA-1tmcA:
81.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		6 / 10 TYR A   9
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.52A 3uprC-1tmcA:
27.9		 3uprC-1tmcA:
81.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		5 / 10 TYR A   9
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.53A 3vriA-1tmcA:
28.7
3vriC-1tmcA:
undetectable		 3vriA-1tmcA:
81.14
3vriC-1tmcA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		6 / 12 TYR A   9
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.51A 3vrjA-1tmcA:
28.6
3vrjC-1tmcA:
undetectable		 3vrjA-1tmcA:
81.14
3vrjC-1tmcA:
7.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		6 / 10 TYR A   9
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.48A 5u98A-1tmcA:
28.3		 5u98A-1tmcA:
81.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)
(Homo
sapiens) 		6 / 10 TYR A   9
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.48A 5u98D-1tmcA:
28.3		 5u98D-1tmcA:
81.14