SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 7 LEU A 127
PHE A 161
ILE A 192
GLY A  96
 None
 1.01A 2v0mC-1tmhA:
undetectable		 2v0mC-1tmhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 7 VAL A   8
ILE A 247
ALA A 250
GLY A 231
 None
 0.79A 2xrzB-1tmhA:
undetectable		 2xrzB-1tmhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 4 GLU A 137
GLY A 139
THR A 141
GLU A 142
 None
 1.14A 3e9xA-1tmhA:
undetectable		 3e9xA-1tmhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 8 ALA A 237
VAL A 215
GLY A  10
ILE A  42
ILE A 247
 None
 1.14A 3ekpA-1tmhA:
undetectable		 3ekpA-1tmhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 12 MET A  62
GLY A  10
VAL A 234
CYH A  38
ILE A 247
 None
 0.92A 3h52B-1tmhA:
undetectable		 3h52B-1tmhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 12 MET A  62
GLY A  10
VAL A 234
CYH A  38
ILE A 247
 None
 1.11A 3h52B-1tmhA:
undetectable		 3h52B-1tmhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 12 ARG A 101
ILE A 111
GLU A 135
GLU A 131
HIS A 195
 None
 1.40A 4a97A-1tmhA:
undetectable
4a97B-1tmhA:
0.0		 4a97A-1tmhA:
19.81
4a97B-1tmhA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 8 ASP A 246
ILE A 247
PHE A 244
GLY A  10
 None
 0.72A 4ac9C-1tmhA:
3.1		 4ac9C-1tmhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 8 GLN A 148
GLU A 131
ILE A 196
VAL A 207
 None
 1.01A 4dx7B-1tmhA:
undetectable		 4dx7B-1tmhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLU A 135
GLY A 130
TYR A 211
VAL A 188
ALA A 185
 None
 1.23A 4foxD-1tmhA:
0.0		 4foxD-1tmhA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLU A 252
ASN A 249
ASP A 246
ILE A 247
VAL A 215
 None
 1.10A 4u8yB-1tmhA:
undetectable		 4u8yB-1tmhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLU A 252
ASN A 249
ASP A 246
ILE A 247
VAL A 215
 None
 1.13A 4u95B-1tmhA:
undetectable		 4u95B-1tmhA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		5 / 11 GLN A 184
VAL A 215
SER A 214
THR A 176
TYR A 211
 None
None
SO4  A 555 (-3.4A)
None
None
 1.47A 5jh7B-1tmhA:
undetectable		 5jh7B-1tmhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 5 ALA A 164
VAL A 207
PHE A 115
ILE A 196
 None
 0.95A 5of1A-1tmhA:
undetectable		 5of1A-1tmhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 5 ALA A 164
VAL A 207
PHE A 115
ILE A 196
 None
 1.04A 5of1B-1tmhA:
undetectable		 5of1B-1tmhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1tmh TRIOSEPHOSPHATE
ISOMERASE
(Escherichia
coli) 		4 / 8 VAL A 117
GLN A  91
PRO A 125
ILE A  93
 None
 1.06A 6hzpA-1tmhA:
undetectable		 6hzpA-1tmhA:
18.09