SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tnd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 7 GLN A 168
ASP A 169
LEU A 155
SER A 147
 None
None
None
GSP  A 351 (-3.3A)
 0.94A 1ig3A-1tndA:
2.8
1ig3B-1tndA:
2.9		 1ig3A-1tndA:
20.24
1ig3B-1tndA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 5 LEU A 126
ASP A 129
VAL A  81
ILE A 132
 None
 0.98A 2aoiB-1tndA:
undetectable		 2aoiB-1tndA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1tnd TRANSDUCIN
(Bos
taurus) 		3 / 3 GLN A  48
LYS A 329
VAL A 331
 None
 0.81A 2jfaB-1tndA:
undetectable		 2jfaB-1tndA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 8 SER A  40
SER A  43
GLY A 199
GLY A  36
 GSP  A 351 (-3.2A)
MG  A 352 ( 2.2A)
GSP  A 351 (-3.6A)
None
 0.79A 2vinA-1tndA:
undetectable		 2vinA-1tndA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1tnd TRANSDUCIN
(Bos
taurus) 		5 / 10 THR A  44
ILE A 220
LEU A  35
GLY A 198
GLY A  38
 GSP  A 351 (-3.8A)
None
None
GSP  A 351 (-3.6A)
GSP  A 351 ( 3.8A)
 1.17A 2wd9C-1tndA:
undetectable		 2wd9C-1tndA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 6 SER A  40
SER A  43
GLY A 199
GLY A  36
 GSP  A 351 (-3.2A)
MG  A 352 ( 2.2A)
GSP  A 351 (-3.6A)
None
 0.71A 3rxfA-1tndA:
undetectable		 3rxfA-1tndA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1tnd TRANSDUCIN
(Bos
taurus) 		3 / 3 LEU A 243
HIS A 240
MET A 239
 None
 0.57A 3thrD-1tndA:
3.4		 3thrD-1tndA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 4 ASN A 265
GLY A  41
ASP A 154
ASP A 146
 GSP  A 351 (-3.2A)
GSP  A 351 (-3.3A)
None
GSP  A 351 (-3.3A)
 1.31A 4n49A-1tndA:
undetectable		 4n49A-1tndA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 6 LEU A 306
ASN A 251
MET A 239
LEU A 262
 None
 1.13A 4okxA-1tndA:
undetectable		 4okxA-1tndA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1tnd TRANSDUCIN
(Bos
taurus) 		6 / 12 GLY A  41
GLY A  38
GLY A 199
SER A  40
ALA A 322
THR A 323
 GSP  A 351 (-3.3A)
GSP  A 351 ( 3.8A)
GSP  A 351 (-3.6A)
GSP  A 351 (-3.2A)
GSP  A 351 (-3.5A)
GSP  A 351 (-3.7A)
 1.42A 4uckA-1tndA:
undetectable		 4uckA-1tndA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tnd TRANSDUCIN
(Bos
taurus) 		5 / 12 GLY A 199
GLY A 198
THR A 177
PHE A 219
ILE A 220
 GSP  A 351 (-3.6A)
GSP  A 351 (-3.6A)
MG  A 352 ( 3.3A)
None
None
 1.10A 4zvmA-1tndA:
6.4
4zvmB-1tndA:
6.8		 4zvmA-1tndA:
20.72
4zvmB-1tndA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 7 ILE A 220
LEU A  34
MET A 194
LEU A  32
 None
 0.92A 5u4sA-1tndA:
2.5		 5u4sA-1tndA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 8 ILE A 220
LEU A  34
MET A 194
LEU A  32
 None
 0.93A 5u4sB-1tndA:
2.5		 5u4sB-1tndA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tnd TRANSDUCIN
(Bos
taurus) 		4 / 6 ILE A  77
LEU A 152
MET A 115
THR A 114
 None
 1.09A 6nmfN-1tndA:
2.4
6nmfW-1tndA:
undetectable		 6nmfN-1tndA:
20.04
6nmfW-1tndA:
12.03