SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens) 		4 / 6 SER A 148
THR A 149
ASN A  63
LEU A  44
 None
 1.32A 1mxdA-1tnrA:
undetectable		 1mxdA-1tnrA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens) 		4 / 5 VAL A  75
TYR A  73
VAL A  67
ASP A 145
 None
 1.16A 2x45A-1tnrA:
undetectable		 2x45A-1tnrA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens) 		4 / 5 VAL A  75
TYR A  73
VAL A  67
ASP A 145
 None
 1.26A 2x45C-1tnrA:
undetectable		 2x45C-1tnrA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens) 		5 / 12 LEU A  33
SER A  64
VAL A  75
HIS A 135
HIS A  99
 None
 1.23A 5h1eA-1tnrA:
undetectable		 5h1eA-1tnrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens) 		4 / 5 LEU A  33
PHE A 165
LEU A  65
PHE A  58
 None
 0.89A 5x1fC-1tnrA:
undetectable
5x1fJ-1tnrA:
0.0		 5x1fC-1tnrA:
20.16
5x1fJ-1tnrA:
16.44