SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1to0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		3 / 4 LYS A 124
ALA A  75
MET A 118
 None
 0.92A 1hk3A-1to0A:
undetectable		 1hk3A-1to0A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		6 / 9 LEU A  76
ILE A 107
GLY A 108
GLY A 112
SER A 126
SER A 128
 None
 0.65A 2qmmA-1to0A:
7.5		 2qmmA-1to0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		6 / 11 LEU A  76
ILE A 107
GLY A 108
GLY A 112
SER A 126
SER A 128
 None
 0.72A 2qmmA-1to0A:
7.5
2qmmB-1to0A:
7.5		 2qmmA-1to0A:
26.15
2qmmB-1to0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		5 / 9 LEU A  76
ILE A 107
GLY A 108
SER A 126
SER A 128
 None
 0.59A 3ai9X-1to0A:
5.3		 3ai9X-1to0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		5 / 12 GLY A  60
GLY A 108
ARG A 120
ALA A 121
ASP A 122
 None
 1.14A 3keeA-1to0A:
undetectable		 3keeA-1to0A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		4 / 5 ASN A 152
ALA A 148
ALA A  89
LYS A  83
 None
 1.43A 3kp2B-1to0A:
undetectable		 3kp2B-1to0A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		4 / 8 ILE A  33
ILE A   3
PHE A 105
SER A  85
 None
 0.75A 4ac9C-1to0A:
undetectable		 4ac9C-1to0A:
15.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		6 / 10 ILE A  78
GLY A 109
GLY A 112
SER A 128
THR A 131
PHE A 132
 None
 1.03A 4fakA-1to0A:
25.9		 4fakA-1to0A:
60.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		7 / 10 LEU A  76
GLY A 108
GLY A 109
PHE A 127
THR A 131
PHE A 132
MET A 137
 None
 1.33A 4fakA-1to0A:
25.9		 4fakA-1to0A:
60.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		10 / 10 LEU A  76
ILE A  78
ILE A 107
GLY A 108
GLY A 112
PHE A 127
SER A 128
THR A 131
PHE A 132
MET A 137
 None
 0.40A 4fakA-1to0A:
25.9		 4fakA-1to0A:
60.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		4 / 7 LYS A  83
GLY A  80
SER A 126
LEU A 125
 None
 1.15A 5bphB-1to0A:
undetectable		 5bphB-1to0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		4 / 6 LYS A  83
GLY A  80
SER A 126
LEU A 125
 None
 1.04A 5bphD-1to0A:
1.5		 5bphD-1to0A:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		9 / 12 LEU A  76
ILE A  78
ILE A 107
GLY A 108
GLY A 112
SER A 126
SER A 128
THR A 131
HIS A 134
 None
 0.51A 5twjA-1to0A:
23.6		 5twjA-1to0A:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		7 / 10 LEU A  76
ILE A  78
ILE A 107
GLY A 108
GLY A 112
SER A 128
HIS A 134
 None
 0.42A 5twjB-1to0A:
23.4		 5twjB-1to0A:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		7 / 12 LEU A  76
ILE A  78
ILE A 107
GLY A 108
LEU A 113
SER A 126
SER A 128
 None
 0.42A 5twjC-1to0A:
23.6		 5twjC-1to0A:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		7 / 11 LEU A  76
ILE A  78
ILE A 107
GLY A 108
GLY A 112
SER A 128
THR A 131
 None
 0.55A 5twjD-1to0A:
23.5		 5twjD-1to0A:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		6 / 11 LEU A  76
ILE A 107
GLY A 108
GLY A 109
SER A 128
THR A 131
 None
 1.25A 5twjD-1to0A:
23.5		 5twjD-1to0A:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA
(Bacillus
subtilis) 		4 / 8 LEU A 139
VAL A 142
LEU A  11
ILE A   5
 None
 1.03A 5v0vA-1to0A:
undetectable		 5v0vA-1to0A:
14.98