SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1to9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		4 / 8 TYR B  47
ASP B  44
TYR B 139
HIS B  21
 HMH  B 302 (-3.7A)
HMH  B 302 (-2.8A)
HMH  B 302 (-3.5A)
None
 1.37A 2ha2A-1to9B:
undetectable		 2ha2A-1to9B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		4 / 8 TYR B  47
ASP B  44
TYR B 139
HIS B  21
 HMH  B 302 (-3.7A)
HMH  B 302 (-2.8A)
HMH  B 302 (-3.5A)
None
 1.38A 2ha2B-1to9B:
undetectable		 2ha2B-1to9B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		5 / 12 SER B  18
PHE B  37
GLY B  26
ILE B  34
PHE B  89
 None
 1.46A 3a25A-1to9B:
undetectable		 3a25A-1to9B:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.08A 5h8tA-1to9B:
undetectable		 5h8tA-1to9B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.09A 5ljbA-1to9B:
undetectable		 5ljbA-1to9B:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		3 / 3 MET B 194
GLU B 184
ARG B 191
 None
 1.03A 5tjyA-1to9B:
undetectable		 5tjyA-1to9B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1to9 THI-4 PROTEIN
(Bacillus
subtilis) 		3 / 3 MET B 194
GLU B 184
ARG B 191
 None
 1.09A 5tjzA-1to9B:
undetectable		 5tjzA-1to9B:
20.15