SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		5 / 9 GLU A  14
ILE A 159
LEU A 209
GLU A 141
ALA A 139
 None
 1.27A 1ctrA-1tolA:
undetectable		 1ctrA-1tolA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		4 / 5 LEU A 209
GLY A 165
ALA A 207
ILE A 159
 None
 0.85A 2aohB-1tolA:
undetectable		 2aohB-1tolA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		4 / 4 THR A  47
VAL A  20
GLY A  55
THR A  56
 None
 1.08A 3cflA-1tolA:
undetectable		 3cflA-1tolA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		4 / 7 LEU A 161
ASP A 164
TYR A 201
TYR A 132
 None
 1.12A 3rodD-1tolA:
undetectable		 3rodD-1tolA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		3 / 3 ASP A  24
ARG A  29
LYS A  22
 None
 1.19A 3wipG-1tolA:
undetectable		 3wipG-1tolA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		3 / 3 ARG A 158
ARG A  29
ASP A  49
 None
 0.95A 3wipG-1tolA:
undetectable
3wipH-1tolA:
undetectable		 3wipG-1tolA:
19.84
3wipH-1tolA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		3 / 3 ASP A 210
ARG A 158
PRO A 208
 None
 0.86A 4wanC-1tolA:
0.0		 4wanC-1tolA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)
(Escherichia
coli;
Escherichia
virus
M13) 		3 / 3 THR A  56
THR A  41
PHE A 211
 None
 0.80A 5cxvA-1tolA:
undetectable		 5cxvA-1tolA:
19.05