SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ton'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1ton TONIN
(Rattus
rattus) 		5 / 12 LEU A  67
GLY A 193
GLY A 142
ILE A  34
LEU A 108
 None
 1.10A 1p91B-1tonA:
undetectable		 1p91B-1tonA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1ton TONIN
(Rattus
rattus) 		5 / 8 ALA A 138
GLY A  43
GLY A 196
ILE A 212
ALA A 226
 None
 1.28A 1sguA-1tonA:
undetectable		 1sguA-1tonA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1ton TONIN
(Rattus
rattus) 		4 / 6 TRP A 141
SER A 139
ALA A 138
ASP A 194
 None
 1.17A 3aruA-1tonA:
undetectable		 3aruA-1tonA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ton TONIN
(Rattus
rattus) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 1.04A 3nvkI-1tonA:
undetectable		 3nvkI-1tonA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1ton TONIN
(Rattus
rattus) 		3 / 3 HIS A  57
HIS A  97
HIS A  99
 ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
 0.58A 3qpkA-1tonA:
undetectable		 3qpkA-1tonA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 1ton TONIN
(Rattus
rattus) 		3 / 3 HIS A  57
HIS A  97
HIS A  99
 ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
 0.54A 3qpkB-1tonA:
undetectable		 3qpkB-1tonA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1ton TONIN
(Rattus
rattus) 		3 / 4 SER A  26
GLY A  19
GLU A 185
 None
 0.62A 3raeA-1tonA:
undetectable
3raeC-1tonA:
undetectable		 3raeA-1tonA:
18.16
3raeC-1tonA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1ton TONIN
(Rattus
rattus) 		4 / 8 ILE A 212
GLY A 211
VAL A  52
GLN A  30
 None
 0.91A 4acbB-1tonA:
2.2
4acbC-1tonA:
2.2		 4acbB-1tonA:
17.34
4acbC-1tonA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1ton TONIN
(Rattus
rattus) 		3 / 4 SER A  26
GLY A  19
GLU A 185
 None
 0.63A 4juoA-1tonA:
undetectable
4juoC-1tonA:
undetectable		 4juoA-1tonA:
18.16
4juoC-1tonA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1ton TONIN
(Rattus
rattus) 		4 / 6 ASN A 145
GLY A 186
PRO A 219
THR A 218
 None
 1.02A 4l1aB-1tonA:
1.2		 4l1aB-1tonA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1ton TONIN
(Rattus
rattus) 		5 / 9 TYR A  94
THR A  54
GLY A 196
VAL A  33
VAL A  31
 None
 1.48A 4mjrA-1tonA:
undetectable		 4mjrA-1tonA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1ton TONIN
(Rattus
rattus) 		4 / 7 LEU A 199
ILE A  47
ILE A 121
VAL A  45
 None
 0.80A 4ojbA-1tonA:
undetectable		 4ojbA-1tonA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1ton TONIN
(Rattus
rattus) 		4 / 8 ASN A 245
PRO A 246
PHE A  89
TRP A  51
 None
 1.38A 5amkA-1tonA:
0.2		 5amkA-1tonA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1ton TONIN
(Rattus
rattus) 		6 / 12 GLY A 211
ILE A 160
ASP A 202
SER A 134
LEU A 181
ALA A 183
 None
 1.46A 5l0zA-1tonA:
undetectable		 5l0zA-1tonA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 1ton TONIN
(Rattus
rattus) 		3 / 3 HIS A  57
HIS A  97
HIS A  99
 ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
ZN  A 247 (-3.2A)
 0.58A 5migA-1tonA:
undetectable		 5migA-1tonA:
16.67