SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
THR A  60
PHE A  70
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
None
None
 1.26A 1mx8A-1towA:
16.8		 1mx8A-1towA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ALA A  75
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.32A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
VAL A  25
ALA A  33
SER A  53
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 ( 4.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.0A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.45A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.5A)
CRZ  A 501 ( 4.8A)
 0.27A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  53
SER A  55
THR A  60
ALA A  75
ARG A  78
ILE A 104
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 ( 4.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 4.8A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.48A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ALA A  75
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.27A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
None
 0.32A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 ILE A  51
THR A  74
CYH A 117
VAL A 115
PHE A  16
 None
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
 1.21A 2qo5A-1towA:
20.1		 2qo5A-1towA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 7 VAL A  80
SER A  82
HIS A  93
THR A  74
 None
 0.60A 3arrA-1towA:
undetectable		 3arrA-1towA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 7 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.65A 3bgdB-1towA:
undetectable		 3bgdB-1towA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 ARG A 106
ASP A  18
GLY A 121
THR A 102
 None
 0.85A 3k4vB-1towA:
undetectable		 3k4vB-1towA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 ILE A  42
CYH A   1
PHE A  64
PHE A  70
SER A  82
 None
 1.37A 3ko0G-1towA:
0.0
3ko0H-1towA:
undetectable
3ko0I-1towA:
0.0
3ko0J-1towA:
0.0		 3ko0G-1towA:
18.18
3ko0H-1towA:
18.18
3ko0I-1towA:
18.18
3ko0J-1towA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR202_1
(PROTEIN S100-A4)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 11 ILE A  42
CYH A   1
SER A  82
PHE A  64
PHE A  70
 None
 1.35A 3ko0Q-1towA:
0.0
3ko0R-1towA:
0.0
3ko0S-1towA:
0.0
3ko0T-1towA:
undetectable		 3ko0Q-1towA:
18.18
3ko0R-1towA:
18.18
3ko0S-1towA:
18.18
3ko0T-1towA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 4.8A)
None
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.43A 3p6gA-1towA:
26.1		 3p6gA-1towA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.19A 3p6gA-1towA:
26.1		 3p6gA-1towA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 7 PHE A  16
MET A  20
ASP A  76
ILE A 104
VAL A 115
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.0A)
CRZ  A 501 ( 4.8A)
None
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.27A 3p6hA-1towA:
26.2		 3p6hA-1towA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		3 / 3 THR A 103
VAL A  92
GLU A 116
 None
 0.72A 3v4tA-1towA:
undetectable
3v4tD-1towA:
undetectable		 3v4tA-1towA:
18.38
3v4tD-1towA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 6 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.75A 4qztA-1towA:
20.9		 4qztA-1towA:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 6 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.73A 4qzuC-1towA:
21.0		 4qzuC-1towA:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.80A 5h8tA-1towA:
20.4		 5h8tA-1towA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.89A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
CRZ  A 501 ( 4.1A)
CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.8A)
 0.96A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34