SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		4 / 7 ILE A  65
PHE A 116
PHE A 127
PHE A 104
 None
 1.16A 1e71M-1tp8A:
undetectable		 1e71M-1tp8A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		4 / 7 ILE A  65
PHE A 116
PHE A 127
PHE A 104
 None
 1.17A 1e72M-1tp8A:
undetectable		 1e72M-1tp8A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		4 / 7 THR A  85
TYR A  96
TYR A  19
LEU A  17
 None
 1.09A 1qzrA-1tp8A:
undetectable		 1qzrA-1tp8A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		4 / 7 THR A  85
TYR A  96
TYR A  19
LEU A  17
 None
 1.09A 1qzrB-1tp8A:
undetectable		 1qzrB-1tp8A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		3 / 3 GLY A  26
ASP A  27
ASN A  20
 None
 0.58A 1vq1A-1tp8A:
undetectable		 1vq1A-1tp8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		3 / 3 ASP A  27
ASN A  43
SER A  49
 None
 0.82A 3lslA-1tp8A:
undetectable
3lslD-1tp8A:
undetectable		 3lslA-1tp8A:
21.65
3lslD-1tp8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		3 / 3 SER A  49
ASP A  27
ASN A  43
 None
 0.95A 3lslA-1tp8A:
undetectable
3lslD-1tp8A:
undetectable		 3lslA-1tp8A:
21.65
3lslD-1tp8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		5 / 9 GLY A   7
ALA A   8
GLY A  11
ILE A  12
LEU A 131
 None
 0.92A 3u7sB-1tp8A:
undetectable		 3u7sB-1tp8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		4 / 8 PHE A 104
TYR A  71
VAL A  81
ILE A  25
 None
 1.08A 4a97G-1tp8A:
undetectable		 4a97G-1tp8A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		5 / 8 VAL A  80
ASP A 125
TYR A  78
GLY A 121
ALA A  24
 None
AMG  A 500 (-2.9A)
AMG  A 500 (-3.7A)
AMG  A 500 ( 3.7A)
None
 1.12A 4m48A-1tp8A:
undetectable		 4m48A-1tp8A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		4 / 8 ASN A 105
PHE A 104
THR A  92
GLY A  94
 None
 0.97A 5nzxA-1tp8A:
undetectable		 5nzxA-1tp8A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 1tp8 AGGLUTININ ALPHA
CHAIN
(Artocarpus
hirsutus) 		5 / 12 GLY A 118
TYR A 130
TYR A  32
PHE A   9
GLN A  42
 None
 1.23A 5v9iD-1tp8A:
undetectable		 5v9iD-1tp8A:
18.09