SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		5 / 12 ILE A  64
PHE A  54
GLY A  55
VAL A  73
TYR A 104
 None
 1.27A 2nyrB-1tq5A:
undetectable		 2nyrB-1tq5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.30A 2y69C-1tq5A:
undetectable
2y69J-1tq5A:
0.0		 2y69C-1tq5A:
20.88
2y69J-1tq5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.33A 2y69P-1tq5A:
undetectable
2y69W-1tq5A:
undetectable		 2y69P-1tq5A:
20.88
2y69W-1tq5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.32A 3abmC-1tq5A:
undetectable
3abmJ-1tq5A:
0.0		 3abmC-1tq5A:
20.88
3abmJ-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.29A 3abmP-1tq5A:
undetectable
3abmW-1tq5A:
undetectable		 3abmP-1tq5A:
20.88
3abmW-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.32A 3ag3C-1tq5A:
undetectable
3ag3J-1tq5A:
0.0		 3ag3C-1tq5A:
20.88
3ag3J-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		3 / 3 ARG A 150
ASP A 159
ASP A 148
 None
 0.92A 3jb3A-1tq5A:
undetectable		 3jb3A-1tq5A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 VAL A 183
LEU A 225
ILE A 185
ASN A 195
 None
 0.98A 4a9kB-1tq5A:
undetectable		 4a9kB-1tq5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		5 / 10 ASP A 148
ARG A 181
ASP A 159
SER A 153
ARG A 129
 None
 1.46A 4fevC-1tq5A:
0.0
4fevD-1tq5A:
0.2
4fevE-1tq5A:
0.5		 4fevC-1tq5A:
22.76
4fevD-1tq5A:
22.76
4fevE-1tq5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 6 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.18A 5b1bC-1tq5A:
undetectable
5b1bJ-1tq5A:
undetectable		 5b1bC-1tq5A:
20.88
5b1bJ-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.26A 5wauC-1tq5A:
undetectable
5wauJ-1tq5A:
undetectable		 5wauC-1tq5A:
20.88
5wauJ-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.28A 5wauc-1tq5A:
undetectable
5wauj-1tq5A:
undetectable		 5wauc-1tq5A:
20.88
5wauj-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.29A 5xdqC-1tq5A:
undetectable
5xdqJ-1tq5A:
undetectable		 5xdqC-1tq5A:
20.88
5xdqJ-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		4 / 5 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.29A 5xdqP-1tq5A:
undetectable
5xdqW-1tq5A:
0.0		 5xdqP-1tq5A:
20.88
5xdqW-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1tq5 PROTEIN YHHW
(Escherichia
coli) 		3 / 3 HIS A 101
HIS A  59
HIS A  57
 CD  A1000 (-3.8A)
CD  A1000 (-3.4A)
CD  A1000 (-3.7A)
 0.56A 5zrdA-1tq5A:
undetectable		 5zrdA-1tq5A:
18.21