SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 163
ALA A 166
GLU A 169
LEU A 170
LEU A  95
 None
None
None
None
4PA  A 701 (-4.2A)
 1.06A 1errB-1tqhA:
undetectable		 1errB-1tqhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 146
GLU A 154
LEU A 132
 None
 0.70A 1v8bA-1tqhA:
6.1		 1v8bA-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 146
GLU A 154
LEU A 132
 None
 0.74A 1v8bB-1tqhA:
6.2		 1v8bB-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 9 GLY A  24
SER A  94
LEU A  95
LEU A 167
HIS A 223
 4PA  A 701 (-3.6A)
4PA  A 701 (-1.4A)
4PA  A 701 (-4.2A)
None
4PA  A 701 (-4.4A)
 0.85A 1y7iA-1tqhA:
15.9		 1y7iA-1tqhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  92
HIS A 235
THR A 226
ILE A 225
 None
 1.45A 1z95A-1tqhA:
0.0		 1z95A-1tqhA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.19A 1z95A-1tqhA:
0.0		 1z95A-1tqhA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 223
VAL A  98
LEU A 178
ILE A 204
SER A 200
 4PA  A 701 (-4.4A)
None
None
None
None
 1.32A 2fj1A-1tqhA:
undetectable		 2fj1A-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A  91
VAL A 113
LEU A 234
HIS A 235
 None
 0.84A 2it4A-1tqhA:
undetectable		 2it4A-1tqhA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 THR A  45
LEU A  20
LEU A  21
GLY A  76
LEU A  80
 None
 1.03A 2ouzA-1tqhA:
0.0		 2ouzA-1tqhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.16A 2q7iA-1tqhA:
undetectable		 2q7iA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.18A 2q7kA-1tqhA:
undetectable		 2q7kA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.20A 2q7lA-1tqhA:
undetectable		 2q7lA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.23A 2q7lA-1tqhA:
undetectable		 2q7lA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 223
SER A  94
VAL A  98
ILE A 204
SER A 200
 4PA  A 701 (-4.4A)
4PA  A 701 (-1.4A)
None
None
None
 1.40A 2xpvA-1tqhA:
undetectable		 2xpvA-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.21A 2yloA-1tqhA:
undetectable		 2yloA-1tqhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 141
VAL A 131
THR A  26
 None
 0.75A 3cyxA-1tqhA:
0.0		 3cyxA-1tqhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  35
GLY A  36
LEU A  39
PHE A  10
ALA A  18
 None
 1.05A 3gwwA-1tqhA:
undetectable		 3gwwA-1tqhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  92
VAL A 113
LEU A 103
CYH A  46
ILE A 238
 None
 1.21A 3h52B-1tqhA:
undetectable		 3h52B-1tqhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 134
GLY A  27
ASP A  31
 None
4PA  A 701 (-3.5A)
4PA  A 701 (-4.1A)
 0.58A 3ou6C-1tqhA:
2.4		 3ou6C-1tqhA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 148
GLU A 142
LYS A 144
 None
 0.90A 3su9A-1tqhA:
undetectable		 3su9A-1tqhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.20A 3zqtA-1tqhA:
undetectable		 3zqtA-1tqhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 10 MET A 115
HIS A  23
GLY A  96
SER A 100
GLY A  36
 None
 1.16A 4a99A-1tqhA:
2.2		 4a99A-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 11 MET A 115
HIS A  23
GLY A  96
SER A 100
GLY A  36
 None
 1.19A 4a99B-1tqhA:
2.2		 4a99B-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 11 MET A 115
HIS A  23
GLY A  96
SER A 100
GLY A  36
 None
 1.16A 4a99C-1tqhA:
2.3		 4a99C-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 11 MET A 115
HIS A  23
GLY A  96
SER A 100
GLY A  36
 None
 1.16A 4a99D-1tqhA:
2.3		 4a99D-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 5 THR A 226
ILE A 225
GLU A 230
PHE A 186
 None
 1.43A 4ac9C-1tqhA:
7.1		 4ac9C-1tqhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 5 THR A 226
ILE A 225
GLU A 230
PHE A 186
 None
 1.44A 4acaC-1tqhA:
6.1		 4acaC-1tqhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 5 THR A 226
ILE A 225
GLU A 230
PHE A 186
 None
 1.44A 4acbC-1tqhA:
6.9		 4acbC-1tqhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 5 GLY A  96
SER A  94
ALA A 117
PHE A  99
 None
4PA  A 701 (-1.4A)
None
None
 0.99A 4m93B-1tqhA:
undetectable
4m93C-1tqhA:
undetectable		 4m93B-1tqhA:
19.85
4m93C-1tqhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.21A 4okbA-1tqhA:
0.0		 4okbA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.30A 4oktA-1tqhA:
undetectable		 4oktA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.22A 4okwA-1tqhA:
undetectable		 4okwA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.22A 4okxA-1tqhA:
undetectable		 4okxA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.16A 4olmA-1tqhA:
undetectable		 4olmA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 188
SER A 221
MET A 195
 None
 0.86A 5ikqA-1tqhA:
0.0		 5ikqA-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 234
VAL A 113
GLY A  92
ALA A  91
LEU A  21
 None
 1.10A 5jvzA-1tqhA:
undetectable		 5jvzA-1tqhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 8 THR A  26
GLY A  27
GLY A  24
SER A  94
 None
4PA  A 701 (-3.5A)
4PA  A 701 (-3.6A)
4PA  A 701 (-1.4A)
 0.68A 5vw9A-1tqhA:
undetectable		 5vw9A-1tqhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 7 ALA A  91
ILE A 215
PHE A 241
ILE A 196
 None
 0.85A 6b5vA-1tqhA:
0.0
6b5vB-1tqhA:
undetectable		 6b5vA-1tqhA:
15.55
6b5vB-1tqhA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 11 THR A 106
ALA A 183
THR A 185
THR A 114
ALA A 117
 None
 1.23A 6efnA-1tqhA:
2.4		 6efnA-1tqhA:
20.68