SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 4 ALA A 195
VAL A 221
ALA A 191
HIS A 193
 None
 1.12A 1q23A-1tqxA:
undetectable		 1q23A-1tqxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 4 ALA A 195
VAL A 221
ALA A 191
HIS A 193
 None
 1.13A 1q23F-1tqxA:
0.0		 1q23F-1tqxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 7 LEU A  13
VAL A  12
VAL A  54
ILE A  55
 None
 0.91A 1t87B-1tqxA:
undetectable		 1t87B-1tqxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 7 LEU A 167
LEU A 174
ARG A 111
GLU A  94
 None
 0.97A 2jn3A-1tqxA:
undetectable		 2jn3A-1tqxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 HIS A  70
MET A 145
MET A  72
 ZN  A 900 (-3.3A)
None
None
 1.30A 2vj1A-1tqxA:
undetectable		 2vj1A-1tqxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A  20
ILE A  35
LEU A  37
ASP A  38
PHE A 205
 None
None
None
ZN  A 900 (-2.6A)
None
 1.14A 3ko0K-1tqxA:
undetectable
3ko0L-1tqxA:
undetectable
3ko0S-1tqxA:
undetectable
3ko0T-1tqxA:
undetectable		 3ko0K-1tqxA:
19.47
3ko0L-1tqxA:
19.47
3ko0S-1tqxA:
19.47
3ko0T-1tqxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASP A  38
SER A  11
LEU A  13
GLN A 154
VAL A  45
 ZN  A 900 (-2.6A)
None
None
None
None
 1.42A 3mbhB-1tqxA:
undetectable		 3mbhB-1tqxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASP A  38
SER A  11
LEU A  13
GLN A 154
VAL A  45
 ZN  A 900 (-2.6A)
None
None
None
None
 1.35A 3mbhC-1tqxA:
undetectable		 3mbhC-1tqxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASP A  38
SER A  11
LEU A  13
GLN A 154
VAL A  45
 ZN  A 900 (-2.6A)
None
None
None
None
 1.38A 3mbhD-1tqxA:
undetectable		 3mbhD-1tqxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASP A  38
SER A  11
LEU A  13
GLN A 154
VAL A  45
 ZN  A 900 (-2.6A)
None
None
None
None
 1.36A 3mbhE-1tqxA:
3.1		 3mbhE-1tqxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 11 ASP A  38
SER A  11
LEU A  13
GLN A 154
VAL A  45
 ZN  A 900 (-2.6A)
None
None
None
None
 1.35A 3mbhF-1tqxA:
undetectable		 3mbhF-1tqxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 HIS A  70
HIS A  92
MET A  72
 ZN  A 900 (-3.3A)
None
None
 0.67A 3mihA-1tqxA:
undetectable		 3mihA-1tqxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A 152
GLY A 181
LEU A 182
VAL A 199
 SO4  A2224 (-3.4A)
SO4  A2224 (-3.3A)
None
None
 0.88A 4fgzA-1tqxA:
undetectable		 4fgzA-1tqxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A 152
GLY A 181
LEU A 182
VAL A 199
 SO4  A2224 (-3.4A)
SO4  A2224 (-3.3A)
None
None
 0.89A 4fgzB-1tqxA:
undetectable		 4fgzB-1tqxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLY A 150
MET A  72
VAL A  39
HIS A  36
VAL A 199
 None
None
None
ZN  A 900 (-3.4A)
None
 1.17A 4okwA-1tqxA:
undetectable		 4okwA-1tqxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLY A 150
MET A  72
VAL A  39
HIS A  36
VAL A 199
 None
None
None
ZN  A 900 (-3.4A)
None
 1.18A 4okxA-1tqxA:
undetectable		 4okxA-1tqxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 THR A 186
ASN A 206
PHE A 205
 None
 0.48A 4pd9A-1tqxA:
undetectable		 4pd9A-1tqxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 VAL A 164
ILE A 198
HIS A  36
LEU A 182
 None
None
ZN  A 900 (-3.4A)
None
 0.85A 4qrcA-1tqxA:
undetectable		 4qrcA-1tqxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 8 ILE A 139
ILE A   8
ILE A 204
ILE A 198
ASP A 179
 None
None
None
None
ZN  A 900 (-3.0A)
 1.41A 5hi2A-1tqxA:
undetectable		 5hi2A-1tqxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 TRP A  34
ILE A  35
ASP A  68
 None
 0.79A 6i0y7-1tqxA:
undetectable		 6i0y7-1tqxA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A  13
HIS A  92
THR A 141
SER A 120
GLY A 118
 None
 1.30A 6mn8A-1tqxA:
undetectable		 6mn8A-1tqxA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 VAL A  12
HIS A  92
THR A 141
SER A 120
GLY A 118
 None
 1.42A 6mn8A-1tqxA:
undetectable		 6mn8A-1tqxA:
17.75