SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 9 LEU B 234
ILE B 233
VAL B  11
GLY B 230
ALA B  78
 None
 1.30A 1e7aA-1tqyB:
undetectable		 1e7aA-1tqyB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		3 / 3 GLU B 160
TYR B 334
PHE A 140
 None
 0.83A 1eqbB-1tqyB:
undetectable		 1eqbB-1tqyB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		3 / 3 GLU B 160
TYR B 334
PHE A 140
 None
 0.82A 1eqbA-1tqyB:
undetectable		 1eqbA-1tqyB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		3 / 3 GLU B 160
TYR B 334
PHE A 140
 None
 0.83A 1eqbD-1tqyB:
undetectable		 1eqbD-1tqyB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		3 / 3 GLU B 160
TYR B 334
PHE A 140
 None
 0.83A 1eqbC-1tqyB:
undetectable		 1eqbC-1tqyB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 SER A 175
GLY A 172
GLY A 177
PHE A 244
LEU A 399
 None
 1.06A 1fduA-1tqyA:
undetectable		 1fduA-1tqyA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 9 ASP B 297
ALA B 388
VAL B 386
GLY B 336
VAL B 325
 None
 1.16A 1hpvB-1tqyB:
undetectable		 1hpvB-1tqyB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 SER A 410
THR A 268
PHE A 408
GLY A 404
 None
None
None
ACE  A 633 (-3.1A)
 1.14A 1icrA-1tqyA:
undetectable
1icrB-1tqyA:
undetectable		 1icrA-1tqyA:
20.53
1icrB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 SER A 410
THR A 268
PHE A 408
GLY A 407
 None
 1.31A 1icrA-1tqyA:
undetectable
1icrB-1tqyA:
undetectable		 1icrA-1tqyA:
20.53
1icrB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.17A 1icrA-1tqyA:
undetectable
1icrB-1tqyA:
undetectable		 1icrA-1tqyA:
20.53
1icrB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 407
SER A 410
THR A 268
PHE A 408
 None
 1.30A 1icrA-1tqyA:
undetectable
1icrB-1tqyA:
undetectable		 1icrA-1tqyA:
20.53
1icrB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 SER A 410
THR A 268
PHE A 408
GLY A 404
 None
None
None
ACE  A 633 (-3.1A)
 1.11A 1icuA-1tqyA:
undetectable
1icuB-1tqyA:
undetectable		 1icuA-1tqyA:
20.53
1icuB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.11A 1icuA-1tqyA:
undetectable
1icuB-1tqyA:
undetectable		 1icuA-1tqyA:
20.53
1icuB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 SER A 410
THR A 268
PHE A 408
GLY A 404
 None
None
None
ACE  A 633 (-3.1A)
 1.14A 1icuC-1tqyA:
undetectable
1icuD-1tqyA:
undetectable		 1icuC-1tqyA:
20.53
1icuD-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.14A 1icuC-1tqyA:
undetectable
1icuD-1tqyA:
undetectable		 1icuC-1tqyA:
20.53
1icuD-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.13A 1icvA-1tqyA:
undetectable
1icvB-1tqyA:
undetectable		 1icvA-1tqyA:
20.53
1icvB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 407
SER A 410
THR A 268
PHE A 408
 None
 1.35A 1icvA-1tqyA:
undetectable
1icvB-1tqyA:
undetectable		 1icvA-1tqyA:
20.53
1icvB-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 5 PHE B 136
GLY A 406
SER B 145
PHE A 408
 None
 1.37A 1icvA-1tqyB:
undetectable
1icvB-1tqyB:
undetectable		 1icvA-1tqyB:
21.36
1icvB-1tqyB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 SER A 410
THR A 268
PHE A 408
GLY A 404
 None
None
None
ACE  A 633 (-3.1A)
 1.17A 1icvC-1tqyA:
undetectable
1icvD-1tqyA:
undetectable		 1icvC-1tqyA:
20.53
1icvD-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.19A 1icvC-1tqyA:
undetectable
1icvD-1tqyA:
undetectable		 1icvC-1tqyA:
20.53
1icvD-1tqyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 SER A 410
THR A 268
PHE A 408
GLY A 404
 None
None
None
ACE  A 633 (-3.1A)
 1.11A 1kqbA-1tqyA:
undetectable
1kqbB-1tqyA:
undetectable		 1kqbA-1tqyA:
19.72
1kqbB-1tqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.08A 1kqbA-1tqyA:
undetectable
1kqbB-1tqyA:
undetectable		 1kqbA-1tqyA:
19.72
1kqbB-1tqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 GLY A 407
SER A 410
THR A 268
PHE A 408
 None
 1.26A 1kqbA-1tqyA:
undetectable
1kqbB-1tqyA:
undetectable		 1kqbA-1tqyA:
19.72
1kqbB-1tqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 SER A 410
THR A 268
PHE A 408
GLY A 404
 None
None
None
ACE  A 633 (-3.1A)
 1.09A 1kqbC-1tqyA:
undetectable
1kqbD-1tqyA:
undetectable		 1kqbC-1tqyA:
19.72
1kqbD-1tqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 GLY A 404
SER A 410
THR A 268
PHE A 408
 ACE  A 633 (-3.1A)
None
None
None
 1.12A 1kqbC-1tqyA:
undetectable
1kqbD-1tqyA:
undetectable		 1kqbC-1tqyA:
19.72
1kqbD-1tqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 ALA A 238
LEU A 354
GLU A 239
LEU A  26
 None
 0.93A 1mt1D-1tqyA:
0.3
1mt1E-1tqyA:
0.0		 1mt1D-1tqyA:
14.15
1mt1E-1tqyA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 ALA A 308
TYR A 305
ILE A 340
GLU A 355
 None
None
None
MG  A1095 (-2.8A)
 1.13A 1oniB-1tqyA:
undetectable
1oniC-1tqyA:
undetectable		 1oniB-1tqyA:
15.49
1oniC-1tqyA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 7 TYR A 305
ILE A 340
GLU A 355
ALA A 308
 None
None
MG  A1095 (-2.8A)
None
 1.11A 1oniG-1tqyA:
undetectable
1oniI-1tqyA:
undetectable		 1oniG-1tqyA:
15.49
1oniI-1tqyA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 11 LEU B 340
GLY B  17
GLY B  15
TYR B  21
LEU B 400
 None
 1.23A 1p91A-1tqyB:
undetectable		 1p91A-1tqyB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B  18
ALA B  12
LEU B 333
VAL B 187
LEU B 234
 None
 1.21A 1s9pB-1tqyB:
undetectable		 1s9pB-1tqyB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 8 ALA A 107
ILE A 351
GLY A 352
GLY A 172
ALA A  73
 None
 1.11A 1sguA-1tqyA:
undetectable		 1sguA-1tqyA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 8 LEU B 371
ALA B 309
ILE B 312
GLY B 298
 None
 0.65A 1sv9A-1tqyB:
undetectable		 1sv9A-1tqyB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 7 ALA B 384
ASP B 292
GLY B 252
ILE B   5
 None
 0.66A 1t7iB-1tqyB:
undetectable		 1t7iB-1tqyB:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 7 ALA B 384
ASP B 292
GLY B 252
ILE B   5
 None
 0.67A 1t7jB-1tqyB:
undetectable		 1t7jB-1tqyB:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 11 GLY A   9
VAL A  10
GLU A  83
ILE A   7
HIS A 365
 None
 1.24A 1vhwA-1tqyA:
undetectable
1vhwD-1tqyA:
undetectable		 1vhwA-1tqyA:
20.84
1vhwD-1tqyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 11 GLY A   9
VAL A  10
GLU A  83
ILE A   7
HIS A 365
 None
 1.25A 1vhwC-1tqyA:
undetectable
1vhwE-1tqyA:
undetectable		 1vhwC-1tqyA:
20.84
1vhwE-1tqyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 11 HIS A 365
GLY A   9
VAL A  10
GLU A  83
ILE A   7
 None
 1.24A 1vhwA-1tqyA:
undetectable
1vhwD-1tqyA:
undetectable		 1vhwA-1tqyA:
20.84
1vhwD-1tqyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 11 HIS A 365
GLY A   9
VAL A  10
GLU A  83
ILE A   7
 None
 1.24A 1vhwC-1tqyA:
undetectable
1vhwE-1tqyA:
undetectable		 1vhwC-1tqyA:
20.84
1vhwE-1tqyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 SER A 171
TYR B 137
ALA A 195
GLY A 194
VAL B 158
 None
 1.25A 1vpoH-1tqyA:
undetectable
1vpoL-1tqyA:
undetectable		 1vpoH-1tqyA:
18.35
1vpoL-1tqyA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 ASP B 192
GLU B 131
TYR B 137
 None
 0.76A 1wsvA-1tqyB:
0.0		 1wsvA-1tqyB:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B   7
ARG B 245
ASP B  85
ALA B  82
ALA B  79
 None
 1.04A 2br4A-1tqyB:
undetectable		 2br4A-1tqyB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B   7
ARG B 245
ASP B  85
ALA B  82
ALA B  79
 None
 1.14A 2br4C-1tqyB:
undetectable		 2br4C-1tqyB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		5 / 12 LEU B 304
GLY B 393
ARG B 391
ASP A 141
ASP B 262
 None
 1.07A 2br4C-1tqyB:
undetectable		 2br4C-1tqyB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B 337
GLY B 230
GLY B 231
ASP B 192
PHE B 109
 None
 0.95A 2dpmA-1tqyB:
undetectable		 2dpmA-1tqyB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 ALA B  45
GLY B 224
SER B 202
 None
 0.59A 2ivuA-1tqyB:
undetectable		 2ivuA-1tqyB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 5 ALA A 111
TRP B 135
LEU A 143
ALA A 110
 None
 1.11A 2jstA-1tqyA:
undetectable
2jstB-1tqyA:
undetectable		 2jstA-1tqyA:
9.87
2jstB-1tqyA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 TRP B 135
GLY A 168
PHE A 405
VAL A 108
ALA A 109
 None
ACE  A 633 ( 4.3A)
ACE  A 633 (-3.7A)
None
None
 1.30A 2kceA-1tqyB:
undetectable		 2kceA-1tqyB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 TRP B 135
GLY A 168
PHE A 405
VAL A 108
ALA A 109
 None
ACE  A 633 ( 4.3A)
ACE  A 633 (-3.7A)
None
None
 1.15A 2kceB-1tqyB:
undetectable		 2kceB-1tqyB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 4 SER A 339
GLY A 310
HIS A 223
ASP A 219
 None
 1.27A 2oxtC-1tqyA:
undetectable		 2oxtC-1tqyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 SER B 184
GLY B 186
GLY B 185
ALA B 171
GLY B 163
 None
 1.03A 2pkkA-1tqyB:
undetectable		 2pkkA-1tqyB:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 9 ASP B 297
ALA B 388
VAL B 386
GLY B 336
VAL B 325
 None
 1.08A 2q5kA-1tqyB:
undetectable		 2q5kA-1tqyB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 VAL A   5
ALA A 179
ALA A 188
ARG A   3
ARG B 173
 None
 1.21A 2qm9A-1tqyA:
undetectable		 2qm9A-1tqyA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		6 / 10 LEU B 340
VAL B  10
GLY B   9
GLY B 337
LEU B 333
SER B 335
 None
 1.44A 2v3kA-1tqyB:
undetectable		 2v3kA-1tqyB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 8 LEU B 340
PRO B 339
LEU B 234
ALA B  82
 None
 0.88A 2vcvF-1tqyB:
undetectable		 2vcvF-1tqyB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 8 ALA A 107
SER A 353
GLY A 194
ALA A 196
 None
 0.86A 2vh3B-1tqyA:
undetectable		 2vh3B-1tqyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 PRO B 339
ALA B 232
ALA B 258
THR A 163
LEU B 157
 None
 1.28A 2x2nB-1tqyB:
undetectable		 2x2nB-1tqyB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		6 / 12 GLY B 169
ILE B 175
ALA B 280
ALA B 284
VAL B   3
LEU B 400
 None
 1.16A 2yqzA-1tqyB:
undetectable		 2yqzA-1tqyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		6 / 12 GLY B 169
ILE B 175
ALA B 280
ALA B 284
VAL B   3
LEU B 400
 None
 1.15A 2yqzB-1tqyB:
undetectable		 2yqzB-1tqyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B 336
SER B 335
LEU B 165
ALA B  12
VAL B 343
 None
 1.16A 2yvlC-1tqyB:
undetectable		 2yvlC-1tqyB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 PHE A 235
PHE A 208
LEU A 237
ALA A 107
SER A 171
 None
 1.47A 3apvA-1tqyA:
0.0		 3apvA-1tqyA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 8 GLY B 390
GLU B 160
GLY B 163
ALA B 162
GLU B 308
 None
 1.10A 3aruA-1tqyB:
undetectable		 3aruA-1tqyB:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 6 GLY B 231
GLY B 336
GLY B 338
GLY B 186
GLY B 164
 None
 0.88A 3bogA-1tqyB:
0.0
3bogC-1tqyB:
undetectable		 3bogA-1tqyB:
undetectable
3bogC-1tqyB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 6 GLY B 231
GLY B 336
GLY B 338
GLY B 186
GLY B 164
 None
 0.91A 3bogB-1tqyB:
0.0
3bogD-1tqyB:
undetectable		 3bogB-1tqyB:
undetectable
3bogD-1tqyB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B 387
PHE B 218
ALA B 306
GLY B 298
VAL B 291
 None
 0.95A 3c6gA-1tqyB:
undetectable		 3c6gA-1tqyB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B 387
PHE B 218
ALA B 306
GLY B 298
VAL B 291
 None
 0.91A 3c6gB-1tqyB:
undetectable		 3c6gB-1tqyB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 9 ALA A 423
SER A 296
LEU A 414
VAL A 360
ILE A 263
 None
 1.30A 3claA-1tqyA:
0.2		 3claA-1tqyA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 8 GLY B 320
ILE B 369
VAL B 323
VAL B 294
 None
 0.81A 3fi0I-1tqyB:
undetectable		 3fi0I-1tqyB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 171
GLY B 169
LEU B 157
GLY B 185
SER B 184
 None
 1.09A 3g2oA-1tqyB:
undetectable		 3g2oA-1tqyB:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 171
GLY B 169
LEU B 157
GLY B 185
SER B 184
 None
 1.09A 3g2oB-1tqyB:
undetectable		 3g2oB-1tqyB:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 7 LEU A 383
ARG A 318
GLY A 282
MET A 285
 None
 1.02A 3hcrB-1tqyA:
2.2		 3hcrB-1tqyA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 ALA A  84
LEU A 246
SER A 353
ILE A 356
LEU A 414
 None
 1.10A 3ia4B-1tqyA:
undetectable		 3ia4B-1tqyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 ALA A  84
LEU A 246
SER A 353
ILE A 356
LEU A 414
 None
 1.12A 3ia4D-1tqyA:
undetectable		 3ia4D-1tqyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 ASN A 316
SER A 403
MET A 285
ILE A 306
ASN A 307
 None
None
None
None
MG  A1095 (-3.1A)
 1.47A 3jb3A-1tqyA:
0.0		 3jb3A-1tqyA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B 390
VAL B 342
GLY B 164
ALA B 397
ALA B 398
 None
 1.04A 3keeB-1tqyB:
undetectable		 3keeB-1tqyB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B 390
VAL B 342
GLY B 164
ALA B 397
ALA B 398
 None
 1.07A 3keeC-1tqyB:
undetectable		 3keeC-1tqyB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 6 VAL B 342
SER B 184
ILE B 144
ALA B 232
 None
 0.83A 3kk6B-1tqyB:
undetectable		 3kk6B-1tqyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		3 / 3 TRP B 392
ALA B 159
VAL A 147
 None
 0.95A 3l8lA-1tqyB:
undetectable
3l8lB-1tqyB:
undetectable		 3l8lA-1tqyB:
3.37
3l8lB-1tqyB:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		3 / 3 ASP A  41
SER A  43
ARG A  36
 None
 0.96A 3loqA-1tqyA:
undetectable		 3loqA-1tqyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		3 / 3 SER A 339
GLY A 310
SER A 225
 None
 0.64A 3loqA-1tqyA:
undetectable		 3loqA-1tqyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 10 ILE A 203
PHE A 235
SER A 225
ALA A 238
LEU A 237
 None
 1.33A 3lw5B-1tqyA:
0.1		 3lw5B-1tqyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 VAL A 176
VAL A 360
LEU A 361
LEU A 414
GLY A  11
 None
 0.88A 3n8wA-1tqyA:
undetectable		 3n8wA-1tqyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 11 LEU A 104
GLY A 349
ALA A 350
SER A 353
LEU A 354
 None
 1.02A 3n8yA-1tqyA:
undetectable		 3n8yA-1tqyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 8 ALA B 384
ASP B 292
GLY B 252
ILE B   5
 None
 0.67A 3nu9A-1tqyB:
undetectable		 3nu9A-1tqyB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 232
GLY B 185
GLY B 336
SER B 335
ALA B  82
 None
 1.06A 3ou6A-1tqyB:
undetectable		 3ou6A-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 232
GLY B 185
GLY B 336
SER B 335
ALA B  82
 None
 1.06A 3ou6B-1tqyB:
undetectable		 3ou6B-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 TYR B 215
GLY B 300
ASP B 305
 None
 0.69A 3ou6C-1tqyB:
undetectable		 3ou6C-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 232
GLY B 185
GLY B 336
SER B 335
ALA B  82
 None
 1.07A 3ou7B-1tqyB:
undetectable		 3ou7B-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 232
GLY B 336
SER B 335
LEU B 340
ALA B  82
 None
 1.34A 3ou7C-1tqyB:
undetectable		 3ou7C-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B  32
GLY B 359
ALA B 358
LEU B 216
ASN B  14
 None
 1.18A 3p5nA-1tqyB:
undetectable		 3p5nA-1tqyB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 GLY B 228
GLU B 229
GLY B 336
VAL B  11
ALA B 105
 None
 1.25A 3qowA-1tqyB:
undetectable		 3qowA-1tqyB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 5 LEU B  74
LEU B  16
GLY B  15
GLY B  17
 None
 0.74A 3si7C-1tqyB:
undetectable
3si7D-1tqyB:
undetectable		 3si7C-1tqyB:
20.47
3si7D-1tqyB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 ARG B 114
PRO B  66
PHE B 111
 None
 0.83A 3thrC-1tqyB:
undetectable		 3thrC-1tqyB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 GLY B 186
THR B 102
ASN B 140
 None
 0.65A 3v4tD-1tqyB:
undetectable		 3v4tD-1tqyB:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		5 / 12 MET B 150
GLY B 152
THR A 268
ASP B  97
LEU B  83
 None
 1.00A 3v8vA-1tqyB:
2.2		 3v8vA-1tqyB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 ARG B 275
ARG B 269
ASP B 262
 None
 0.96A 3wipG-1tqyB:
undetectable
3wipH-1tqyB:
undetectable		 3wipG-1tqyB:
20.24
3wipH-1tqyB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 LEU A  90
LEU A  95
GLU A 247
ALA A  81
SER A 251
 None
 1.33A 4aqlA-1tqyA:
undetectable		 4aqlA-1tqyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 LEU A  90
LEU A  95
PHE A 192
GLU A 247
SER A 251
 None
 1.21A 4aqlA-1tqyA:
undetectable		 4aqlA-1tqyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 11 VAL A 236
GLU A  52
ALA A  51
THR A  34
VAL A  49
 None
 1.03A 4e0fA-1tqyA:
undetectable		 4e0fA-1tqyA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 9 SER B 396
SER B 259
ASN B 395
GLY A 160
ASP B 262
 None
 1.41A 4fxsA-1tqyB:
undetectable		 4fxsA-1tqyB:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 8 PRO B  90
VAL B 182
GLY B  99
MET B 150
 None
 0.85A 4klrB-1tqyB:
undetectable		 4klrB-1tqyB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 11 SER B 184
GLY B 185
LEU B 157
ILE A 356
LEU A 414
 None
 1.11A 4kt0A-1tqyB:
undetectable
4kt0J-1tqyB:
undetectable		 4kt0A-1tqyB:
20.21
4kt0J-1tqyB:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 8 ASP B 297
ALA B 388
VAL B 386
GLY B 336
VAL B 325
 None
 1.13A 4ll3A-1tqyB:
undetectable		 4ll3A-1tqyB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 8 ASP B 297
ALA B 388
VAL B 386
PRO B 326
VAL B 325
 None
 1.42A 4ll3A-1tqyB:
undetectable		 4ll3A-1tqyB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 9 ASP B 297
ALA B 388
VAL B 386
GLY B 336
VAL B 325
 None
 1.14A 4ll3B-1tqyB:
undetectable		 4ll3B-1tqyB:
11.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		7 / 12 CYH A 169
PHE A 208
HIS A 309
HIS A 346
LEU A 348
GLY A 404
PHE A 405
 ACE  A 633 (-1.5A)
None
None
None
ACE  A 633 ( 4.9A)
ACE  A 633 (-3.1A)
ACE  A 633 (-3.7A)
 0.49A 4ls7A-1tqyA:
65.1		 4ls7A-1tqyA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		7 / 12 CYH A 169
PHE A 208
HIS A 309
HIS A 346
LEU A 348
GLY A 404
PHE A 405
 ACE  A 633 (-1.5A)
None
None
None
ACE  A 633 ( 4.9A)
ACE  A 633 (-3.1A)
ACE  A 633 (-3.7A)
 0.52A 4ls7A-1tqyA:
65.1
4ls7B-1tqyA:
64.8		 4ls7A-1tqyA:
39.23
4ls7B-1tqyA:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B 103
GLY B 338
PRO B 339
GLY B 336
LEU B 387
 None
 1.02A 4n49A-1tqyB:
undetectable		 4n49A-1tqyB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 6 LEU A 354
GLU A 239
VAL A 108
ALA A 107
 None
 1.14A 4nkvC-1tqyA:
0.0		 4nkvC-1tqyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 GLY A 406
GLY A 404
THR A 214
LEU A 348
GLY A 168
 None
ACE  A 633 (-3.1A)
None
ACE  A 633 ( 4.9A)
ACE  A 633 ( 4.3A)
 0.92A 4o33A-1tqyA:
undetectable		 4o33A-1tqyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 GLY A 406
GLY A 404
THR A 214
LEU A 348
GLY A 168
 None
ACE  A 633 (-3.1A)
None
ACE  A 633 ( 4.9A)
ACE  A 633 ( 4.3A)
 0.89A 4o3fA-1tqyA:
undetectable		 4o3fA-1tqyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 5 GLY B  31
LEU B 191
ILE B  51
LEU B 333
 NA  B1091 (-3.8A)
None
None
None
 0.70A 4o8fA-1tqyB:
0.0		 4o8fA-1tqyB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 THR A 167
THR A 170
ASP A 174
TYR A 266
 None
 1.47A 4oltA-1tqyA:
undetectable		 4oltA-1tqyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 THR A 167
THR A 170
ASP A 174
TYR A 266
 None
 1.48A 4oltB-1tqyA:
undetectable		 4oltB-1tqyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 11 LEU B 165
LEU B 168
ALA B 398
VAL B 343
LEU B 346
 None
 1.11A 4p65C-1tqyB:
undetectable
4p65D-1tqyB:
undetectable
4p65J-1tqyB:
undetectable
4p65L-1tqyB:
undetectable		 4p65C-1tqyB:
5.47
4p65D-1tqyB:
8.84
4p65J-1tqyB:
8.84
4p65L-1tqyB:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ALA B  75
GLU B 229
VAL B 187
LEU A 143
LEU B 191
 None
 1.15A 4qrcA-1tqyB:
undetectable		 4qrcA-1tqyB:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 5 THR A 167
THR A 170
ASP A 174
TYR A 266
 None
 1.48A 4qwpA-1tqyA:
undetectable		 4qwpA-1tqyA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 9 THR A 400
ILE A 351
LEU A 363
VAL A  10
ILE A   7
 MG  A1095 (-3.9A)
None
None
None
None
 1.26A 4r38C-1tqyA:
undetectable		 4r38C-1tqyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		3 / 3 ARG A  31
GLN A  22
GLU A  25
 None
 0.93A 4tvtA-1tqyA:
undetectable		 4tvtA-1tqyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 8 ALA A  77
SER A 175
ALA A 350
ALA A 241
 None
 0.66A 4twdF-1tqyA:
undetectable
4twdG-1tqyA:
undetectable
4twdH-1tqyA:
undetectable
4twdI-1tqyA:
undetectable
4twdJ-1tqyA:
undetectable		 4twdF-1tqyA:
21.92
4twdG-1tqyA:
21.92
4twdH-1tqyA:
21.92
4twdI-1tqyA:
21.92
4twdJ-1tqyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		4 / 8 SER A 175
ALA A 350
ALA A 241
ALA A  77
 None
 0.77A 4twdF-1tqyA:
undetectable
4twdG-1tqyA:
undetectable
4twdH-1tqyA:
undetectable
4twdI-1tqyA:
undetectable
4twdJ-1tqyA:
undetectable		 4twdF-1tqyA:
21.92
4twdG-1tqyA:
21.92
4twdH-1tqyA:
21.92
4twdI-1tqyA:
21.92
4twdJ-1tqyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 SER B 396
ALA B 398
VAL B 399
 None
 0.66A 4x20C-1tqyB:
undetectable		 4x20C-1tqyB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 8 LEU B 254
LEU B 236
LEU B 234
LEU B 400
ALA B 398
 None
 1.16A 4z90A-1tqyB:
undetectable
4z90B-1tqyB:
undetectable
4z90C-1tqyB:
undetectable
4z90D-1tqyB:
undetectable
4z90E-1tqyB:
undetectable		 4z90A-1tqyB:
23.49
4z90B-1tqyB:
23.49
4z90C-1tqyB:
23.49
4z90D-1tqyB:
23.49
4z90E-1tqyB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 9 THR B 141
ILE B 144
GLY B 186
LEU B 168
LEU B 236
 None
 1.18A 4ze0A-1tqyB:
undetectable		 4ze0A-1tqyB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		5 / 12 GLY A 406
GLY A 404
ALA A 272
ILE B 146
ALA A 107
 None
ACE  A 633 (-3.1A)
None
None
None
 0.93A 5bw4B-1tqyA:
undetectable		 5bw4B-1tqyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 THR B 330
ALA B  12
ASN B  14
 None
 0.64A 5ersA-1tqyB:
undetectable		 5ersA-1tqyB:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 ALA A  84
LEU A 246
SER A 353
ILE A 356
LEU A 414
 None
 1.04A 5hi6B-1tqyA:
undetectable		 5hi6B-1tqyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 VAL B 293
ASP B 292
LEU B 165
ALA B 345
SER B 348
 None
 1.30A 5hnzB-1tqyB:
undetectable		 5hnzB-1tqyB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 8 ILE B 144
GLY B 186
LEU B 168
LEU B 236
 None
 0.84A 5hs1A-1tqyB:
undetectable		 5hs1A-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		4 / 5 PRO B 339
HIS B 170
LEU B 181
PHE A 408
 None
 1.45A 5igjA-1tqyB:
undetectable		 5igjA-1tqyB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 LEU A 104
GLY A 349
ALA A 350
SER A 353
LEU A 354
 None
 1.14A 5ikqB-1tqyA:
undetectable		 5ikqB-1tqyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 LEU A 104
GLY A 349
ALA A 350
SER A 353
LEU A 354
 None
 1.09A 5ikrA-1tqyA:
undetectable		 5ikrA-1tqyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 LEU A 104
GLY A 349
ALA A 350
SER A 353
LEU A 354
 None
 1.11A 5ikrB-1tqyA:
undetectable		 5ikrB-1tqyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 PRO B 288
LEU B 281
PHE B 316
GLY B 317
GLY B 313
 None
 1.07A 5l6eA-1tqyB:
undetectable		 5l6eA-1tqyB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 VAL A 144
GLU B 160
ARG B 332
GLY B 336
LEU B 333
 None
 1.45A 5m50B-1tqyA:
2.1		 5m50B-1tqyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		3 / 3 SER A 251
ALA A 252
THR A   8
 None
 0.75A 5n0xB-1tqyA:
undetectable		 5n0xB-1tqyA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 VAL B 293
ASP B 292
LEU B 165
ALA B 345
SER B 348
 None
 1.25A 5nd2B-1tqyB:
undetectable		 5nd2B-1tqyB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 VAL B 293
ASP B 292
LEU B 165
ALA B 345
SER B 348
 None
 1.19A 5nd7B-1tqyB:
undetectable		 5nd7B-1tqyB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 8 VAL A 180
ILE A   7
LEU A 246
MET A 412
SER A 410
 None
 1.42A 5numA-1tqyA:
undetectable		 5numA-1tqyA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		5 / 12 ASP A 197
GLY A 349
ALA A 350
GLY A 194
SER A  74
 None
 0.87A 5t2zB-1tqyA:
undetectable		 5t2zB-1tqyA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B 168
LEU B 165
GLY B 338
GLY B 337
LEU B 400
 None
 1.09A 5uc1A-1tqyB:
undetectable		 5uc1A-1tqyB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B 168
LEU B 165
GLY B 338
GLY B 337
LEU B 400
 None
 1.07A 5uc1B-1tqyB:
undetectable		 5uc1B-1tqyB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 7 GLY B   9
LEU B 234
LEU B 349
GLY B 231
LEU B 340
 None
 1.40A 5vkqA-1tqyB:
undetectable
5vkqB-1tqyB:
undetectable		 5vkqA-1tqyB:
12.80
5vkqB-1tqyB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ARG B 382
ASP B 283
GLY B 256
GLU B 253
ARG B 172
 None
 1.42A 5x7pB-1tqyB:
0.8		 5x7pB-1tqyB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		3 / 3 ALA B 358
VAL B 226
TYR B 215
 None
 0.70A 5zmqH-1tqyB:
undetectable		 5zmqH-1tqyB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B 165
GLY B 163
VAL B  11
VAL B 187
ASP B 188
 None
 1.26A 6bxlB-1tqyB:
undetectable		 6bxlB-1tqyB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 LEU B 165
GLY B 164
VAL B  11
VAL B 187
ASP B 188
 None
 0.99A 6bxlB-1tqyB:
undetectable		 6bxlB-1tqyB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 12 ASP B 166
ALA B 105
GLY B 338
GLY B 164
ASP B 297
 None
 1.04A 6clxA-1tqyB:
undetectable		 6clxA-1tqyB:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
(Streptomyces
coelicolor) 		3 / 3 GLY A 105
ASP A 197
ILE A 351
 None
 0.61A 6dgxB-1tqyA:
undetectable		 6dgxB-1tqyA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		5 / 10 PHE A 192
ALA A 153
PHE B 261
PHE B 394
VAL A 162
 None
 1.35A 6hu9C-1tqyA:
undetectable		 6hu9C-1tqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 11 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.96A 6mb5A-1tqyB:
0.4		 6mb5A-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 10 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.92A 6mb9A-1tqyB:
0.4		 6mb9A-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 10 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.94A 6mb9B-1tqyB:
0.2		 6mb9B-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 10 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.93A 6mb9C-1tqyB:
0.2		 6mb9C-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2
(Streptomyces
coelicolor) 		5 / 10 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 1.01A 6mb9D-1tqyB:
0.4		 6mb9D-1tqyB:
11.81