SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 6 HIS A 102
PHE A 208
ILE A 158
SER A 214
 None
 1.17A 1sbrA-1tr1A:
undetectable
1sbrB-1tr1A:
undetectable		 1sbrA-1tr1A:
17.04
1sbrB-1tr1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		3 / 3 ASP A 235
TYR A 229
GLU A 313
 None
 0.73A 1vm1A-1tr1A:
undetectable		 1vm1A-1tr1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		5 / 12 ILE A 170
PHE A 164
ALA A 200
ILE A 288
ILE A 291
 None
 1.16A 2rlcA-1tr1A:
undetectable		 2rlcA-1tr1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		5 / 11 ASN A 165
GLU A 166
TYR A 296
GLU A 352
TRP A 398
 None
GOL  A2000 ( 4.4A)
GOL  A2000 (-4.0A)
GOL  A2000 (-3.8A)
GOL  A2000 (-3.2A)
 0.88A 2v3dB-1tr1A:
16.8		 2v3dB-1tr1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 6 SER A  57
VAL A 104
TYR A 100
ASP A  64
 None
 1.15A 2x45A-1tr1A:
undetectable		 2x45A-1tr1A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 7 SER A  57
VAL A 104
TYR A 100
ASP A  64
 None
 1.15A 2x45B-1tr1A:
undetectable		 2x45B-1tr1A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 8 TYR A 120
ASN A 165
PHE A 414
TRP A 398
 None
None
GOL  A2000 (-3.9A)
GOL  A2000 (-3.2A)
 1.49A 3bjwD-1tr1A:
undetectable		 3bjwD-1tr1A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		3 / 3 GLU A 408
GLU A 405
TRP A 326
 None
GOL  A2000 (-2.6A)
None
 1.01A 3hrdA-1tr1A:
undetectable
3hrdE-1tr1A:
undetectable
3hrdF-1tr1A:
undetectable		 3hrdA-1tr1A:
20.20
3hrdE-1tr1A:
20.20
3hrdF-1tr1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 5 ILE A 113
TYR A 395
TRP A 434
MET A 416
 None
 1.44A 3phaA-1tr1A:
7.2		 3phaA-1tr1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 8 GLY A 344
ILE A 291
ASP A 248
SER A 247
 None
 0.71A 3pwwA-1tr1A:
undetectable		 3pwwA-1tr1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 6 VAL A 104
TYR A 100
GLU A  22
ILE A  21
 None
 1.09A 3q5sA-1tr1A:
undetectable		 3q5sA-1tr1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 7 PRO A 182
ILE A  34
GLN A 129
GLY A 133
 None
 0.97A 4a3uB-1tr1A:
13.5		 4a3uB-1tr1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		5 / 11 GLN A 311
MET A 176
PHE A 309
GLY A 308
GLY A 271
 None
 1.50A 4a6nC-1tr1A:
0.0		 4a6nC-1tr1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 6 LEU A 124
ILE A  34
ASN A 175
VAL A 193
 None
 0.89A 4a9kA-1tr1A:
undetectable		 4a9kA-1tr1A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		5 / 12 GLY A 415
VAL A 382
TYR A 395
ASN A 353
HIS A 378
 None
 1.45A 4ffwA-1tr1A:
undetectable		 4ffwA-1tr1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		3 / 3 ASP A 123
TRP A 398
SER A  79
 None
GOL  A2000 (-3.2A)
None
 1.07A 4lrhB-1tr1A:
undetectable		 4lrhB-1tr1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		5 / 12 ALA A 190
ASN A 175
LEU A 184
ASN A 186
GLY A 132
 None
 1.31A 4qckA-1tr1A:
undetectable		 4qckA-1tr1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 4 VAL A 223
ALA A 220
ILE A 350
THR A 351
 None
 1.13A 5e4dB-1tr1A:
0.0		 5e4dB-1tr1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCW_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE P)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 4 PHE A 208
GLN A 216
ILE A 217
ARG A 209
 None
 1.38A 5jcwA-1tr1A:
0.0		 5jcwA-1tr1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCW_B_ACTB303_0
(GLUTATHIONE
S-TRANSFERASE P)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 4 PHE A 208
GLN A 216
ILE A 217
ARG A 209
 None
 1.38A 5jcwB-1tr1A:
0.0		 5jcwB-1tr1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 8 THR A  14
THR A  16
ARG A 426
ILE A 417
 None
 1.11A 5jhdE-1tr1A:
undetectable
5jhdG-1tr1A:
undetectable		 5jhdE-1tr1A:
18.49
5jhdG-1tr1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		3 / 3 SER A 297
TYR A 296
TYR A 295
 None
GOL  A2000 (-4.0A)
None
 0.68A 5lakA-1tr1A:
0.0
5lakI-1tr1A:
undetectable		 5lakA-1tr1A:
20.76
5lakI-1tr1A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		3 / 3 SER A 297
TYR A 296
TYR A 295
 None
GOL  A2000 (-4.0A)
None
 0.56A 5lakC-1tr1A:
0.0
5lakJ-1tr1A:
undetectable		 5lakC-1tr1A:
20.76
5lakJ-1tr1A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 8 GLU A 405
TRP A 326
CYH A 169
TYR A 296
 GOL  A2000 (-2.6A)
None
None
GOL  A2000 (-4.0A)
 1.46A 5oajD-1tr1A:
0.0
5oajE-1tr1A:
0.0		 5oajD-1tr1A:
22.31
5oajE-1tr1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 5 GLN A 367
ASP A 368
SER A 431
ARG A 371
 None
 1.31A 5w4zA-1tr1A:
7.7		 5w4zA-1tr1A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 6 PRO A 221
GLY A 292
LEU A 337
VAL A 223
 None
 0.86A 5x80A-1tr1A:
undetectable
5x80B-1tr1A:
undetectable		 5x80A-1tr1A:
14.58
5x80B-1tr1A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 5 HIS A 378
MET A 298
ASN A 294
VAL A 223
 None
 1.50A 5xdhD-1tr1A:
0.0		 5xdhD-1tr1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP9_B_ACTB304_0
(GLUTATHIONE
S-TRANSFERASE P)		 1tr1 BETA-GLUCOSIDASE A
(Paenibacillus
polymyxa) 		4 / 4 PHE A 208
GLN A 216
ILE A 217
ARG A 209
 None
 1.39A 6ap9B-1tr1A:
0.0		 6ap9B-1tr1A:
17.75