SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G78_A_REAA200_1 (CELLULAR RETINOIC ACID-BINDING PROTEIN 2)	1tr7	FIMH PROTEIN (Escherichia coli)	5 / 12	LEU B 129 ILE B 126 ALA B 127 VAL B 67 VAL B 75	None	1.11A	2g78A-1tr7B: undetectable	2g78A-1tr7B: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GLQ_A_RABA602_2 (ADENOSYLHOMOCYSTEINA SE)	1tr7	FIMH PROTEIN (Escherichia coli)	4 / 5	GLN B 133 THR B 134 GLU B 89 THR B 90	DEG B 502 (-3.2A) None None None	1.46A	3glqA-1tr7B: undetectable	3glqA-1tr7B: 15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GLQ_B_RABB602_2 (ADENOSYLHOMOCYSTEINA SE)	1tr7	FIMH PROTEIN (Escherichia coli)	4 / 5	GLN B 133 THR B 134 GLU B 89 THR B 90	DEG B 502 (-3.2A) None None None	1.48A	3glqB-1tr7B: undetectable	3glqB-1tr7B: 15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_B_EPAB1_2 (PROSTAGLANDIN G/H SYNTHASE 2)	1tr7	FIMH PROTEIN (Escherichia coli)	4 / 7	VAL B 75 VAL B 105 LEU B 38 SER B 39	None	0.90A	3hs6B-1tr7B: undetectable	3hs6B-1tr7B: 14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_C_STRC603_1 (CYTOCHROME P450 21-HYDROXYLASE)	1tr7	FIMH PROTEIN (Escherichia coli)	5 / 12	VAL B 20 ILE B 42 ILE B 148 VAL B 154 LEU B 34	None	1.02A	4y8wC-1tr7B: undetectable	4y8wC-1tr7B: 16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_A_7V7A201_1 (ENDO-1,4-BETA-XYLANA SE A)	1tr7	FIMH PROTEIN (Escherichia coli)	4 / 8	TRP B 103 THR B 57 TYR B 77 ARG B 60	None	1.01A	5tzoA-1tr7B: undetectable	5tzoA-1tr7B: 24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_B_7V7B202_1 (ENDO-1,4-BETA-XYLANA SE A)	1tr7	FIMH PROTEIN (Escherichia coli)	4 / 8	TRP B 103 THR B 57 TYR B 77 ARG B 60	None	1.13A	5tzoB-1tr7B: undetectable	5tzoB-1tr7B: 24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_C_7V7C202_1 (ENDO-1,4-BETA-XYLANA SE A)	1tr7	FIMH PROTEIN (Escherichia coli)	4 / 8	TRP B 103 THR B 57 TYR B 77 ARG B 60	None	1.09A	5tzoC-1tr7B: undetectable	5tzoC-1tr7B: 24.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2G78_A_REAA200_1","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","1tr7","FIMH PROTEIN","Escherichia coli",5,"LEU B 129;ILE B 126;ALA B 127;VAL B  67;VAL B  75","None","1.11A","2g78A-1tr7B:undetectable","2g78A-1tr7B:20.35"],["3GLQ_A_RABA602_2","ADENOSYLHOMOCYSTEINASE","1tr7","FIMH PROTEIN","Escherichia coli",4,"GLN B 133;THR B 134;GLU B  89;THR B  90","DEG B 502 (-3.2A);None;None;None","1.46A","3glqA-1tr7B:undetectable","3glqA-1tr7B:15.79"],["3GLQ_B_RABB602_2","ADENOSYLHOMOCYSTEINASE","1tr7","FIMH PROTEIN","Escherichia coli",4,"GLN B 133;THR B 134;GLU B  89;THR B  90","DEG B 502 (-3.2A);None;None;None","1.48A","3glqB-1tr7B:undetectable","3glqB-1tr7B:15.79"],["3HS6_B_EPAB1_2","PROSTAGLANDIN G\/H SYNTHASE 2","1tr7","FIMH PROTEIN","Escherichia coli",4,"VAL B  75;VAL B 105;LEU B  38;SER B  39","None","0.90A","3hs6B-1tr7B:undetectable","3hs6B-1tr7B:14.12"],["4Y8W_C_STRC603_1","CYTOCHROME P450 21-HYDROXYLASE","1tr7","FIMH PROTEIN","Escherichia coli",5,"VAL B  20;ILE B  42;ILE B 148;VAL B 154;LEU B  34","None","1.02A","4y8wC-1tr7B:undetectable","4y8wC-1tr7B:16.39"],["5TZO_A_7V7A201_1","ENDO-1,4-BETA-XYLANASE A","1tr7","FIMH PROTEIN","Escherichia coli",4,"TRP B 103;THR B  57;TYR B  77;ARG B  60","None","1.01A","5tzoA-1tr7B:undetectable","5tzoA-1tr7B:24.51"],["5TZO_B_7V7B202_1","ENDO-1,4-BETA-XYLANASE A","1tr7","FIMH PROTEIN","Escherichia coli",4,"TRP B 103;THR B  57;TYR B  77;ARG B  60","None","1.13A","5tzoB-1tr7B:undetectable","5tzoB-1tr7B:24.51"],["5TZO_C_7V7C202_1","ENDO-1,4-BETA-XYLANASE A","1tr7","FIMH PROTEIN","Escherichia coli",4,"TRP B 103;THR B  57;TYR B  77;ARG B  60","None","1.09A","5tzoC-1tr7B:undetectable","5tzoC-1tr7B:24.51"]]