SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A 147
ASP A 146
GLY A 153
VAL A 198
ILE A 148
 None
 1.14A 1hpvB-1tt4A:
undetectable		 1hpvB-1tt4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 ASP A 298
HIS A 156
ASP A 310
 None
 0.57A 1nw5A-1tt4A:
undetectable		 1nw5A-1tt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A 314
TRP A 263
LEU A 264
PHE A 270
 None
 1.27A 1ru9H-1tt4A:
undetectable
1ru9L-1tt4A:
undetectable		 1ru9H-1tt4A:
17.63
1ru9L-1tt4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A 314
TRP A 263
LEU A 264
PHE A 270
 None
 1.29A 1rukH-1tt4A:
undetectable
1rukL-1tt4A:
undetectable		 1rukH-1tt4A:
17.63
1rukL-1tt4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A  83
ALA A  86
ALA A  87
LEU A  92
ALA A  40
 None
 1.00A 1xiuB-1tt4A:
undetectable		 1xiuB-1tt4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 11 ILE A  83
ALA A  86
ALA A  87
LEU A  92
ALA A  40
 None
 1.04A 2aclE-1tt4A:
undetectable		 2aclE-1tt4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 SER A 329
ASP A  68
CYH A  66
 None
 1.07A 2br4E-1tt4A:
undetectable		 2br4E-1tt4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 VAL A  22
SER A  31
HIS A  90
THR A  36
 None
 1.10A 2f78A-1tt4A:
undetectable		 2f78A-1tt4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 VAL A  22
SER A  31
HIS A  90
THR A  36
 None
 1.10A 2f78B-1tt4A:
undetectable		 2f78B-1tt4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A 211
LEU A 223
ASP A 222
ASP A 218
 None
 0.91A 2j2pA-1tt4A:
undetectable
2j2pB-1tt4A:
undetectable		 2j2pA-1tt4A:
20.60
2j2pB-1tt4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 11 LEU A  14
ALA A 261
VAL A 236
VAL A 137
VAL A 139
 None
 1.07A 2nnpB-1tt4A:
undetectable		 2nnpB-1tt4A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 LEU A  30
ASP A  29
ILE A 359
GLN A  21
 None
 0.96A 2qqcG-1tt4A:
undetectable
2qqcJ-1tt4A:
undetectable		 2qqcG-1tt4A:
9.69
2qqcJ-1tt4A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		6 / 12 LEU A 358
PRO A 101
MET A 171
THR A  99
GLY A  97
LEU A 361
 None
 1.46A 2uvnA-1tt4A:
undetectable		 2uvnA-1tt4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ALA A  72
ASP A  70
GLY A 255
ILE A 257
THR A  13
 None
 1.08A 3gguA-1tt4A:
undetectable		 3gguA-1tt4A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A  72
ASP A  70
GLY A 255
ILE A 257
THR A  13
 None
 1.07A 3gguB-1tt4A:
undetectable		 3gguB-1tt4A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 ARG A 313
VAL A 238
LEU A 164
ILE A 227
 None
 0.99A 3gp0A-1tt4A:
undetectable		 3gp0A-1tt4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 10 LEU A  14
ALA A 261
VAL A 236
VAL A 137
VAL A 139
 None
 1.09A 3nu9B-1tt4A:
undetectable		 3nu9B-1tt4A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A  83
ALA A  86
ALA A  87
LEU A  92
ALA A  40
 None
 1.03A 3uvvB-1tt4A:
undetectable		 3uvvB-1tt4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 LYS A 281
TYR A 280
ARG A 284
 None
 1.42A 4gc9A-1tt4A:
undetectable		 4gc9A-1tt4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 8 ALA A 147
ASP A 146
GLY A 153
VAL A 198
ILE A 148
 None
 1.21A 4ll3A-1tt4A:
undetectable		 4ll3A-1tt4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 9 ALA A 147
ASP A 146
GLY A 153
VAL A 198
ILE A 148
 None
 1.22A 4ll3B-1tt4A:
undetectable		 4ll3B-1tt4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 11 ALA A 163
LEU A 164
LEU A 256
LEU A 314
LEU A 315
 None
 1.20A 4wg0I-1tt4A:
undetectable
4wg0J-1tt4A:
undetectable
4wg0K-1tt4A:
undetectable		 4wg0I-1tt4A:
3.40
4wg0J-1tt4A:
3.40
4wg0K-1tt4A:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 LEU A 264
PRO A 269
LEU A 150
TYR A 149
 None
 1.06A 4z4fA-1tt4A:
undetectable		 4z4fA-1tt4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 VAL A 295
THR A 297
ARG A 304
 None
 0.77A 5b2sB-1tt4A:
undetectable		 5b2sB-1tt4A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 5 GLY A  15
THR A  13
GLN A  71
THR A  63
 None
 1.26A 5h5fA-1tt4A:
undetectable		 5h5fA-1tt4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 CYH A 141
LEU A 150
HIS A 262
LEU A 265
 None
 1.05A 5hpuC-1tt4A:
undetectable
5hpuD-1tt4A:
undetectable		 5hpuC-1tt4A:
4.82
5hpuD-1tt4A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 GLY A 134
PHE A 133
GLU A  19
ASP A 242
 None
 1.05A 5n5dB-1tt4A:
undetectable		 5n5dB-1tt4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 7 LEU A 164
ILE A  16
GLY A  15
LEU A  14
ILE A 331
 None
 0.82A 5vkqA-1tt4A:
undetectable
5vkqB-1tt4A:
undetectable		 5vkqA-1tt4A:
11.99
5vkqB-1tt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 8 LEU A 164
ILE A  16
GLY A  15
LEU A  14
ILE A 331
 None
 0.83A 5vkqB-1tt4A:
undetectable
5vkqC-1tt4A:
undetectable		 5vkqB-1tt4A:
11.99
5vkqC-1tt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 ILE A  50
ILE A  23
LEU A  92
HIS A  90
 None
 0.94A 5vkqB-1tt4A:
undetectable
5vkqC-1tt4A:
undetectable		 5vkqB-1tt4A:
11.99
5vkqC-1tt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 9 LEU A 164
ILE A  16
GLY A  15
LEU A  14
ILE A 331
 None
 0.78A 5vkqC-1tt4A:
undetectable
5vkqD-1tt4A:
undetectable		 5vkqC-1tt4A:
11.99
5vkqD-1tt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 ILE A  50
ILE A  23
LEU A  92
HIS A  90
 None
 0.91A 5vkqC-1tt4A:
undetectable
5vkqD-1tt4A:
undetectable		 5vkqC-1tt4A:
11.99
5vkqD-1tt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A  97
GLY A 134
VAL A 132
ILE A  16
ALA A  62
 None
 1.18A 5x7fA-1tt4A:
undetectable		 5x7fA-1tt4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 GLN A 258
ILE A 148
HIS A 152
 None
 0.68A 5z12B-1tt4A:
0.0		 5z12B-1tt4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A  83
ALA A  86
ALA A  87
LEU A  92
ALA A  40
 None
 0.99A 6a60D-1tt4A:
undetectable		 6a60D-1tt4A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1tt4 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 VAL A 238
GLU A 237
ILE A 257
 None
MG  A 400 (-2.6A)
None
 0.65A 6f7lB-1tt4A:
undetectable		 6f7lB-1tt4A:
21.03