SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ttu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 6 LEU A 590
GLU A 606
ASP A 585
PRO A 563
 None
 1.15A 1ditH-1ttuA:
undetectable
1ditP-1ttuA:
undetectable		 1ditH-1ttuA:
20.14
1ditP-1ttuA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 7 GLY A 291
ILE A 292
PRO A 240
ILE A 219
 None
 0.75A 1n49A-1ttuA:
undetectable		 1n49A-1ttuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		5 / 10 SER A 608
LEU A 609
PHE A 586
LEU A 642
HIS A 582
 None
 1.35A 1y7iB-1ttuA:
undetectable		 1y7iB-1ttuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		5 / 10 LEU A 302
ALA A 345
ILE A 217
ASP A 323
LEU A 244
 None
 1.05A 1yi4A-1ttuA:
undetectable		 1yi4A-1ttuA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		3 / 3 GLY A 230
ASP A 334
SER A 335
 None
 0.19A 3brfA-1ttuA:
50.4		 3brfA-1ttuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		3 / 3 HIS A 610
PHE A 656
PHE A 594
 None
 0.75A 3lk0D-1ttuA:
undetectable		 3lk0D-1ttuA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		5 / 9 ILE A 242
GLY A 291
ILE A 292
PRO A 240
ILE A 219
 None
 0.94A 3nu4A-1ttuA:
undetectable		 3nu4A-1ttuA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		5 / 9 ILE A 242
GLY A 291
ILE A 292
PRO A 240
ILE A 219
 None
 0.96A 3s45A-1ttuA:
undetectable		 3s45A-1ttuA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		3 / 3 SER A 605
PHE A 586
LYS A 587
 None
 0.84A 3u88A-1ttuA:
undetectable		 3u88A-1ttuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 5 VAL A 479
ILE A 515
MET A 500
ILE A 516
 None
 0.94A 4c8bA-1ttuA:
undetectable		 4c8bA-1ttuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 7 ILE A 471
TYR A 451
PRO A 489
HIS A 494
 None
 1.10A 4g5jA-1ttuA:
0.0		 4g5jA-1ttuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 6 VAL A 455
VAL A 449
ILE A 386
LEU A 394
 None
 0.99A 4l1wB-1ttuA:
undetectable		 4l1wB-1ttuA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 6 LEU A 505
ASP A 502
ILE A 530
HIS A 518
 None
 1.10A 4xi3C-1ttuA:
undetectable		 4xi3C-1ttuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 5 VAL A 461
ASP A 459
PHE A 220
GLY A 423
 EDO  A  51 (-4.6A)
None
EDO  A  53 (-3.9A)
EDO  A  53 ( 3.9A)
 0.91A 4xp6A-1ttuA:
0.0		 4xp6A-1ttuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 4 CYH A 562
PHE A 548
ILE A 219
GLY A 356
 None
 1.39A 5hesB-1ttuA:
0.0		 5hesB-1ttuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 4 CYH A 562
PHE A 548
ILE A 242
GLY A 356
 None
 1.26A 5hesB-1ttuA:
0.0		 5hesB-1ttuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		5 / 12 GLY A 356
ILE A 355
PHE A 347
TYR A 546
LEU A 286
 None
None
None
EDO  A  54 ( 4.6A)
None
 1.35A 5nz0A-1ttuA:
undetectable		 5nz0A-1ttuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		4 / 8 GLN A 554
PRO A 558
ILE A 559
GLU A 550
 None
 0.93A 6hzpA-1ttuA:
undetectable		 6hzpA-1ttuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR
(Caenorhabditis
elegans) 		5 / 12 PRO A 369
LEU A 493
ILE A 539
ILE A 386
ALA A 387
 None
EDO  A  58 ( 4.7A)
None
None
None
 1.38A 6qxsD-1ttuA:
undetectable		 6qxsD-1ttuA:
19.46