SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ttw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		3 / 3 LEU A 105
VAL A 108
LEU A 112
 None
 0.49A 1mz9B-1ttwA:
undetectable		 1mz9B-1ttwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		4 / 8 PHE A  11
LEU A 109
LEU A  95
LEU A  48
 None
 1.04A 2bfpA-1ttwA:
undetectable		 2bfpA-1ttwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		4 / 8 ARG A  80
SER A 111
LEU A 112
VAL A 108
 None
 0.91A 2bxgA-1ttwA:
undetectable		 2bxgA-1ttwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		4 / 5 LEU A   7
GLN A 104
THR A 100
GLU A  10
 None
 1.30A 3n58C-1ttwA:
undetectable		 3n58C-1ttwA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 10 CYH A  81
LEU A  91
LEU A 119
ALA A  54
LEU A  57
 None
 0.92A 4p65A-1ttwA:
undetectable
4p65B-1ttwA:
undetectable
4p65F-1ttwA:
undetectable
4p65H-1ttwA:
undetectable		 4p65A-1ttwA:
9.35
4p65B-1ttwA:
15.05
4p65F-1ttwA:
15.05
4p65H-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 11 CYH A  81
LEU A  91
LEU A 119
ALA A  54
LEU A  57
 None
 0.95A 4p65C-1ttwA:
undetectable
4p65D-1ttwA:
undetectable
4p65J-1ttwA:
undetectable
4p65L-1ttwA:
undetectable		 4p65C-1ttwA:
9.35
4p65D-1ttwA:
15.05
4p65J-1ttwA:
15.05
4p65L-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 11 CYH A  81
LEU A  91
LEU A 119
ALA A  54
LEU A  57
 None
 1.00A 4p65E-1ttwA:
undetectable
4p65F-1ttwA:
undetectable
4p65J-1ttwA:
undetectable
4p65L-1ttwA:
undetectable		 4p65E-1ttwA:
9.35
4p65F-1ttwA:
15.05
4p65J-1ttwA:
15.05
4p65L-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 11 LEU A  57
CYH A  81
LEU A  91
LEU A 119
ALA A  54
 None
 0.96A 4p65B-1ttwA:
undetectable
4p65D-1ttwA:
undetectable
4p65G-1ttwA:
undetectable
4p65H-1ttwA:
undetectable		 4p65B-1ttwA:
15.05
4p65D-1ttwA:
15.05
4p65G-1ttwA:
9.35
4p65H-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 12 LEU A  57
CYH A  81
LEU A  91
LEU A 119
ALA A  54
 None
 0.93A 4p65B-1ttwA:
undetectable
4p65D-1ttwA:
undetectable
4p65I-1ttwA:
undetectable
4p65J-1ttwA:
undetectable		 4p65B-1ttwA:
15.05
4p65D-1ttwA:
15.05
4p65I-1ttwA:
9.35
4p65J-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 12 LEU A  57
CYH A  81
LEU A  91
LEU A 119
ALA A  54
 None
 0.92A 4p65F-1ttwA:
undetectable
4p65H-1ttwA:
undetectable
4p65K-1ttwA:
undetectable
4p65L-1ttwA:
undetectable		 4p65F-1ttwA:
15.05
4p65H-1ttwA:
15.05
4p65K-1ttwA:
9.35
4p65L-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1ttw SECRETION CHAPERONE
(Yersinia
pestis) 		5 / 12 PHE A  11
ILE A  20
LEU A   8
ALA A  50
LEU A  48
 None
 1.34A 5zwrB-1ttwA:
undetectable		 5zwrB-1ttwA:
15.23