SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		5 / 12 VAL B  72
GLY B  73
GLY B 121
PRO B 120
TYR B 102
 HEC  B 255 (-4.0A)
HEC  B 255 (-2.8A)
None
None
None
 1.20A 1fduC-1tu2B:
undetectable		 1fduC-1tu2B:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		5 / 12 GLY B 178
THR B 179
ALA B 227
GLY B 204
SER B 203
 None
 1.13A 1nbiC-1tu2B:
undetectable		 1nbiC-1tu2B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		5 / 12 GLY B 178
THR B 179
ALA B 227
GLY B 204
SER B 203
 None
 1.13A 1nbiD-1tu2B:
undetectable		 1nbiD-1tu2B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		5 / 12 ASN B 154
GLY B 241
GLN B 242
ARG B  19
GLN B 159
 HEC  B 255 (-3.9A)
None
None
None
None
 1.36A 1p93A-1tu2B:
undetectable		 1p93A-1tu2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		3 / 3 GLN B 159
HIS B  26
ARG B 155
 None
HEC  B 255 (-3.3A)
None
 0.72A 1zlqA-1tu2B:
undetectable		 1zlqA-1tu2B:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		4 / 4 GLN B  38
GLU B 246
ILE B 247
PRO B  37
 None
 1.49A 2fcnA-1tu2B:
undetectable		 2fcnA-1tu2B:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		5 / 11 ASN B 170
GLN B 159
ASN B  24
GLY B 158
SER B 167
 None
None
None
HEC  B 255 (-3.7A)
HEC  B 255 ( 4.0A)
 1.47A 4a99C-1tu2B:
undetectable		 4a99C-1tu2B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		4 / 5 ILE B 142
ILE B 247
TYR B 147
GLU B 246
 None
 1.14A 4a99D-1tu2B:
undetectable		 4a99D-1tu2B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		4 / 6 ILE B  90
VAL B 131
LEU B  78
ILE B  84
 None
 0.80A 4asdA-1tu2B:
undetectable		 4asdA-1tu2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		4 / 6 GLY B  81
GLU B  80
TYR B 147
ILE B 247
 None
 0.66A 5kmfA-1tu2B:
undetectable
5kmfC-1tu2B:
undetectable		 5kmfA-1tu2B:
20.74
5kmfC-1tu2B:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 1tu2 APOCYTOCHROME F
(Nostoc
sp.
PCC
7119) 		5 / 12 ALA B  28
ASN B 234
LYS B  30
GLY B 239
GLY B 158
 None
None
None
None
HEC  B 255 (-3.7A)
 0.77A 6c79A-1tu2B:
undetectable		 6c79A-1tu2B:
13.28