SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.40A 11gsA-1tu7A:
31.0		 11gsA-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 7 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.39A 11gsB-1tu7A:
30.9		 11gsB-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A 106
GLY A 204
TYR A   7
GLY A  12
 None
 0.71A 11gsB-1tu7A:
30.9		 11gsB-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 10 TYR A   7
PHE A   8
TYR A 106
PRO A 201
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.45A 13gsA-1tu7A:
30.7		 13gsA-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 ARG A  11
TYR A   7
GLU A 156
HIS A 161
 GOL  A2001 (-3.9A)
None
None
None
 1.02A 1nx9A-1tu7A:
undetectable		 1nx9A-1tu7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 ARG A  11
TYR A   7
GLU A 156
HIS A 161
 GOL  A2001 (-3.9A)
None
None
None
 1.02A 1nx9B-1tu7A:
undetectable		 1nx9B-1tu7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 ARG A  11
TYR A   7
GLU A 156
HIS A 161
 GOL  A2001 (-3.9A)
None
None
None
 1.02A 1nx9C-1tu7A:
undetectable		 1nx9C-1tu7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 ARG A  11
TYR A   7
GLU A 156
HIS A 161
 GOL  A2001 (-3.9A)
None
None
None
 1.01A 1nx9D-1tu7A:
undetectable		 1nx9D-1tu7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 6 ARG A  18
ALA A  14
ILE A  66
PRO A  51
 None
None
None
GSH  A1001 (-4.3A)
 1.25A 1oniB-1tu7A:
undetectable
1oniC-1tu7A:
undetectable		 1oniB-1tu7A:
25.13
1oniC-1tu7A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 PHE A 155
LEU A  76
PHE A 178
MET A 182
 None
 1.13A 1wrlE-1tu7A:
undetectable		 1wrlE-1tu7A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 LEU A 154
PHE A  90
LEU A 158
LEU A 125
ALA A 126
 None
 1.04A 2bxpA-1tu7A:
undetectable		 2bxpA-1tu7A:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.47A 2gssA-1tu7A:
30.9		 2gssA-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.47A 2gssB-1tu7A:
30.9		 2gssB-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 9 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.40A 3csjB-1tu7A:
30.7		 3csjB-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.39A 3gssA-1tu7A:
30.9		 3gssA-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A 106
TYR A   7
THR A   6
GLY A  12
 None
 0.90A 3gssA-1tu7A:
30.9		 3gssA-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.40A 3gssB-1tu7A:
30.9		 3gssB-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A 106
TYR A   7
THR A   6
GLY A  12
 None
 0.78A 3gssB-1tu7A:
30.9		 3gssB-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 10 TYR A   7
PHE A   8
GLY A  12
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.35A 3km6A-1tu7A:
30.6		 3km6A-1tu7A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 9 TYR A   7
PHE A   8
GLY A  12
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.38A 3kmoA-1tu7A:
30.3		 3kmoA-1tu7A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.38A 3kmoB-1tu7A:
30.4		 3kmoB-1tu7A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.49A 3n9jA-1tu7A:
30.7		 3n9jA-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 8 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.50A 3n9jB-1tu7A:
30.5		 3n9jB-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A 106
GLY A 204
TYR A   7
GLY A  12
 None
 0.75A 3n9jB-1tu7A:
30.5		 3n9jB-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 GLY A 144
GLY A 138
LEU A 174
VAL A 177
 None
 0.91A 4fgzA-1tu7A:
undetectable		 4fgzA-1tu7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 GLY A 144
GLY A 138
LEU A 174
VAL A 177
 None
 0.92A 4fgzB-1tu7A:
undetectable		 4fgzB-1tu7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ARG A  95
GLY A  64
ILE A  60
ARG A  18
LEU A   5
 GSH  A1001 (-3.6A)
None
None
None
None
 1.36A 4kosA-1tu7A:
undetectable		 4kosA-1tu7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ARG A  95
GLY A  64
ILE A  60
ARG A  18
LEU A   5
 GSH  A1001 (-3.6A)
None
None
None
None
 1.38A 4kotA-1tu7A:
undetectable		 4kotA-1tu7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 11 ARG A  95
GLY A  64
ILE A  60
ARG A  18
LEU A   5
 GSH  A1001 (-3.6A)
None
None
None
None
 1.39A 4koyA-1tu7A:
undetectable		 4koyA-1tu7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 4 LEU A  50
ARG A  32
ILE A  33
PHE A   8
 GSH  A1001 (-4.5A)
None
None
GSH  A1001 (-4.8A)
 1.31A 5kirB-1tu7A:
0.0		 5kirB-1tu7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ASP A  30
PRO A  16
ARG A  18
GLY A  12
LEU A  13
 None
None
None
None
GSH  A1001 (-4.4A)
 1.42A 5m50B-1tu7A:
undetectable		 5m50B-1tu7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ILE A 147
LEU A 154
LEU A 143
GLY A 144
TYR A  86
 None
 1.19A 6r2eA-1tu7A:
0.0		 6r2eA-1tu7A:
22.73