SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 309
ASN A  85
LEU A  93
LEU A  94
 None
 1.02A 1e7cA-1tufA:
0.0		 1e7cA-1tufA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A  32
SER A 421
SER A  50
GLU A  51
 None
 1.10A 2c8aD-1tufA:
undetectable		 2c8aD-1tufA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 283
LEU A 281
ALA A  64
ASP A 280
PHE A 235
 None
 1.17A 2ejtA-1tufA:
undetectable		 2ejtA-1tufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 CYH A 356
THR A  44
GLU A  40
VAL A 387
 None
 1.08A 2fb2A-1tufA:
3.3		 2fb2A-1tufA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 387
VAL A 392
ASP A 376
 None
 0.71A 2fumD-1tufA:
undetectable		 2fumD-1tufA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  65
PHE A  76
LEU A 301
SER A 308
TYR A  61
 None
None
None
LLP  A  83 ( 4.7A)
None
 1.43A 3apvA-1tufA:
undetectable		 3apvA-1tufA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  65
PHE A  76
LEU A 301
SER A 308
TYR A  61
 None
None
None
LLP  A  83 ( 4.7A)
None
 1.45A 3apvB-1tufA:
undetectable		 3apvB-1tufA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  77
ILE A 122
SER A 119
PHE A 145
ILE A 302
 None
 0.99A 3cd2A-1tufA:
undetectable		 3cd2A-1tufA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 401
TYR A 269
ILE A 267
 AZ1  A 502 ( 4.1A)
None
None
 0.75A 3eteA-1tufA:
undetectable
3eteB-1tufA:
undetectable		 3eteA-1tufA:
22.86
3eteB-1tufA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 221
PHE A  65
GLY A 262
GLY A 263
ILE A 225
 None
None
LLP  A  83 ( 4.6A)
LLP  A  83 ( 3.9A)
None
 1.34A 3owxA-1tufA:
undetectable
3owxB-1tufA:
undetectable		 3owxA-1tufA:
20.20
3owxB-1tufA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 259
PHE A  65
GLY A 263
GLY A 264
ILE A 225
 None
None
LLP  A  83 ( 3.9A)
LLP  A  83 ( 3.4A)
None
 1.21A 3owxA-1tufA:
undetectable
3owxB-1tufA:
undetectable		 3owxA-1tufA:
20.20
3owxB-1tufA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 145
GLY A 137
ILE A  77
ALA A 101
ALA A  79
 None
 0.97A 3sufB-1tufA:
undetectable		 3sufB-1tufA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 143
LYS A 121
LYS A 120
 None
 1.13A 4k50E-1tufA:
undetectable		 4k50E-1tufA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 143
LYS A 121
LYS A 120
 None
 1.19A 4k50I-1tufA:
undetectable		 4k50I-1tufA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 206
LEU A 211
GLY A 220
GLU A 304
ALA A 170
 None
None
None
LLP  A  83 ( 3.6A)
None
 1.07A 4pclA-1tufA:
undetectable		 4pclA-1tufA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A 400
ALA A  84
ALA A  79
TYR A  80
LEU A  94
 None
LLP  A  83 ( 3.6A)
None
None
None
 1.38A 4v1fA-1tufA:
undetectable
4v1fB-1tufA:
undetectable		 4v1fA-1tufA:
12.21
4v1fB-1tufA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 221
PHE A  65
GLY A 262
GLY A 263
ILE A 225
 None
None
LLP  A  83 ( 4.6A)
LLP  A  83 ( 3.9A)
None
 1.40A 4zvmA-1tufA:
undetectable
4zvmB-1tufA:
undetectable		 4zvmA-1tufA:
19.47
4zvmB-1tufA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 221
PHE A  76
GLY A 262
GLY A 263
ILE A 225
 None
None
LLP  A  83 ( 4.6A)
LLP  A  83 ( 3.9A)
None
 1.27A 4zvmA-1tufA:
undetectable
4zvmB-1tufA:
undetectable		 4zvmA-1tufA:
19.47
4zvmB-1tufA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 259
PHE A  65
GLY A 263
GLY A 264
ILE A 225
 None
None
LLP  A  83 ( 3.9A)
LLP  A  83 ( 3.4A)
None
 1.16A 4zvmA-1tufA:
undetectable
4zvmB-1tufA:
undetectable		 4zvmA-1tufA:
19.47
4zvmB-1tufA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A 401
GLY A 306
ILE A 302
GLY A 263
 AZ1  A 502 ( 4.1A)
LLP  A  83 ( 3.0A)
None
LLP  A  83 ( 3.9A)
 0.86A 5alcL-1tufA:
undetectable		 5alcL-1tufA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  31
VAL A  48
LEU A  38
 None
 0.51A 5e5jB-1tufA:
undetectable		 5e5jB-1tufA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A 341
HIS A 351
GLY A 399
 None
 0.83A 5gwzB-1tufA:
undetectable		 5gwzB-1tufA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.32A 5lg3B-1tufA:
0.0		 5lg3B-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.30A 5lg3C-1tufA:
0.0		 5lg3C-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.28A 5lg3D-1tufA:
undetectable		 5lg3D-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.28A 5lg3G-1tufA:
undetectable		 5lg3G-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
 None
 0.93A 5lg3I-1tufA:
undetectable		 5lg3I-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 160
LEU A 163
ILE A 134
ILE A 135
GLU A 139
 None
 1.01A 5mvmD-1tufA:
undetectable
5mvmE-1tufA:
undetectable		 5mvmD-1tufA:
10.51
5mvmE-1tufA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 316
VAL A  48
THR A 420
GLU A 432
 None
 0.77A 5tudD-1tufA:
undetectable		 5tudD-1tufA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 249
VAL A 247
MET A 204
VAL A 198
ILE A 173
 None
 1.07A 5v02B-1tufA:
undetectable
5v02R-1tufA:
undetectable		 5v02B-1tufA:
13.61
5v02R-1tufA:
16.39