SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tuh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 7 ARG A  77
ASP A 145
TRP A 144
TYR A  78
 None
 1.48A 1cebA-1tuhA:
undetectable		 1cebA-1tuhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 12 PHE A  75
PHE A  47
PHE A 124
GLY A 103
GLY A  31
 None
 1.08A 1igxA-1tuhA:
undetectable		 1igxA-1tuhA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 12 ASN A 107
ILE A 122
ASP A 133
TYR A  32
ALA A  88
 None
 1.28A 1kijB-1tuhA:
undetectable		 1kijB-1tuhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 5 TRP A 148
GLY A  57
PRO A  56
PHE A 138
 None
 1.37A 2rezA-1tuhA:
1.5		 2rezA-1tuhA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 7 PHE A  35
GLY A  38
GLY A  84
PHE A  47
 None
 0.96A 3ko0M-1tuhA:
undetectable
3ko0P-1tuhA:
undetectable		 3ko0M-1tuhA:
20.78
3ko0P-1tuhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 7 LEU A  90
SER A  37
ASN A  36
THR A  42
 None
 1.04A 3lm8A-1tuhA:
undetectable
3lm8C-1tuhA:
undetectable		 3lm8A-1tuhA:
19.11
3lm8C-1tuhA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 5 LEU A  46
GLN A  23
THR A  27
GLU A  45
 None
 1.49A 3n58C-1tuhA:
undetectable		 3n58C-1tuhA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 10 PHE A  47
PHE A 138
PHE A  86
TYR A  78
PHE A  35
 None
 1.39A 3r6wA-1tuhA:
undetectable
3r6wB-1tuhA:
undetectable		 3r6wA-1tuhA:
21.66
3r6wB-1tuhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 12 PHE A  72
ALA A  70
PHE A  75
LEU A  43
PHE A 124
 None
 1.27A 4kykA-1tuhA:
1.6
4kykB-1tuhA:
1.5		 4kykA-1tuhA:
21.74
4kykB-1tuhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 12 PHE A  75
ALA A  73
PHE A 124
GLY A  63
PHE A 138
 None
 1.07A 4kykA-1tuhA:
1.6
4kykB-1tuhA:
1.5		 4kykA-1tuhA:
21.74
4kykB-1tuhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 12 TYR A  32
VAL A 131
GLY A 103
GLY A  31
ASP A 133
 None
 1.18A 4mm8A-1tuhA:
undetectable		 4mm8A-1tuhA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 11 TYR A  32
VAL A 131
GLY A 103
GLY A  31
ASP A 133
 None
 1.13A 4mm9A-1tuhA:
undetectable		 4mm9A-1tuhA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		5 / 10 TYR A  32
VAL A 131
GLY A 103
GLY A  31
ASP A 133
 None
 1.17A 4mmcA-1tuhA:
undetectable		 4mmcA-1tuhA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 7 ARG A 130
ASN A  50
GLU A  49
ARG A  68
 None
 1.13A 6b8kA-1tuhA:
undetectable		 6b8kA-1tuhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1tuh HYPOTHETICAL PROTEIN
EGC068
(uncultured
bacterium) 		4 / 8 ARG A 130
ASN A  50
GLU A  49
ARG A  68
 None
 1.07A 6b94A-1tuhA:
undetectable		 6b94A-1tuhA:
21.90