SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		6 / 12 SER A 334
GLY A 314
GLY A 418
ALA A 292
VAL A 293
LEU A 429
 None
 1.43A 1jg4A-1tuoA:
undetectable		 1jg4A-1tuoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 11 LEU A 343
ALA A 108
MET A 105
LEU A  91
HIS A 110
 None
 1.43A 1kt7A-1tuoA:
0.0		 1kt7A-1tuoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 GLY A 103
LEU A  68
LEU A  43
LEU A  72
ILE A 136
 None
 0.97A 1mx1D-1tuoA:
undetectable		 1mx1D-1tuoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y1P_A_ACTA803_0
(ALDEHYDE REDUCTASE
II)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 4 HIS A 381
GLU A 374
GLN A 446
PHE A 370
 None
 1.32A 1y1pA-1tuoA:
0.0		 1y1pA-1tuoA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 9 THR A  31
LEU A  32
HIS A  42
ALA A  38
LEU A  77
 None
 1.27A 2azqA-1tuoA:
undetectable		 2azqA-1tuoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 THR A  57
GLY A 189
GLY A 187
ASP A 347
ILE A 349
 None
 1.06A 2b25A-1tuoA:
undetectable		 2b25A-1tuoA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 5 PRO A  87
ALA A 252
ASP A 122
ASP A 347
 None
 1.19A 2nyuB-1tuoA:
2.0		 2nyuB-1tuoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 GLY A 103
PRO A 127
GLY A 126
ALA A 104
LEU A  68
 None
 0.95A 2plwA-1tuoA:
undetectable		 2plwA-1tuoA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		3 / 3 ARG A 431
SER A 433
TYR A 442
 None
 0.93A 2q2hA-1tuoA:
undetectable
2q2hB-1tuoA:
undetectable		 2q2hA-1tuoA:
15.02
2q2hB-1tuoA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 VAL A  51
ILE A 136
ALA A 104
PHE A 120
LEU A  35
 None
 1.12A 2qb4A-1tuoA:
0.0		 2qb4A-1tuoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 7 ARG A 440
GLU A 333
GLU A 332
SER A 334
 None
 1.14A 2zt7A-1tuoA:
3.8		 2zt7A-1tuoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 PHE A 370
VAL A 255
VAL A 373
LEU A 296
THR A 294
 None
 1.25A 3elzA-1tuoA:
undetectable		 3elzA-1tuoA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		3 / 3 GLU A 425
GLU A 424
TRP A 295
 None
 1.25A 3hrdA-1tuoA:
undetectable
3hrdE-1tuoA:
undetectable
3hrdF-1tuoA:
undetectable		 3hrdA-1tuoA:
23.43
3hrdE-1tuoA:
23.43
3hrdF-1tuoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 6 VAL A  80
LEU A 343
ALA A  94
LEU A  98
 None
 0.91A 3kk6B-1tuoA:
undetectable		 3kk6B-1tuoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 6 PHE A  27
PHE A  64
HIS A  33
THR A  31
 None
 1.24A 3lb3B-1tuoA:
0.0		 3lb3B-1tuoA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 8 VAL A  95
GLY A 103
ILE A 128
GLY A 125
 None
 0.81A 3n9jB-1tuoA:
undetectable		 3n9jB-1tuoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 LEU A  81
ALA A 104
GLY A 103
GLY A  54
LEU A 106
 None
 1.26A 3ou7D-1tuoA:
undetectable		 3ou7D-1tuoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 11 LEU A 193
ALA A 252
ASP A 251
VAL A 337
ILE A 349
 None
 1.01A 3oxxD-1tuoA:
undetectable		 3oxxD-1tuoA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 PHE A  14
LEU A  32
LEU A  35
ALA A  65
ALA A  67
 None
 1.03A 3vw7A-1tuoA:
undetectable		 3vw7A-1tuoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 5 LEU A 350
HIS A 342
HIS A 283
GLU A 341
 None
 1.24A 4a7bB-1tuoA:
undetectable		 4a7bB-1tuoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 4 HIS A 167
GLU A 162
HIS A 199
LEU A 202
 None
 1.25A 4m2rA-1tuoA:
undetectable		 4m2rA-1tuoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 5 GLY A 175
ALA A 172
PHE A 176
GLU A 357
 None
 1.02A 4m93B-1tuoA:
undetectable
4m93C-1tuoA:
undetectable		 4m93B-1tuoA:
17.28
4m93C-1tuoA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		3 / 3 ILE A 225
ASP A 387
ARG A 254
 None
 0.76A 4pstA-1tuoA:
undetectable		 4pstA-1tuoA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 7 LEU A  35
ALA A 133
LEU A 139
ILE A 128
 None
 0.86A 4ubsA-1tuoA:
undetectable		 4ubsA-1tuoA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 6 ALA A  65
LEU A 106
MET A 105
LEU A  91
 None
 0.93A 4xoyA-1tuoA:
undetectable		 4xoyA-1tuoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 7 ILE A 349
LEU A 164
GLY A 195
LYS A 194
 None
 0.79A 4z69A-1tuoA:
undetectable		 4z69A-1tuoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 188
PHE A  14
ILE A  12
PHE A 120
LEU A  68
 None
 1.10A 5eshA-1tuoA:
undetectable		 5eshA-1tuoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 7 PHE A  14
ILE A  12
PHE A 120
LEU A  68
 None
 1.02A 5esmA-1tuoA:
0.0		 5esmA-1tuoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		4 / 8 ILE A  12
PHE A 120
LEU A 106
LEU A 116
 None
 0.84A 5hs1A-1tuoA:
undetectable		 5hs1A-1tuoA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 11 LEU A 297
GLY A 301
LEU A 271
ARG A 280
ALA A 275
 None
 0.95A 5o96G-1tuoA:
undetectable		 5o96G-1tuoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1tuo PUTATIVE
PHOSPHOMANNOMUTASE
(Thermus
thermophilus) 		5 / 12 LEU A  50
TYR A  39
LEU A  43
GLY A  48
GLY A  49
 None
 0.97A 5wyqB-1tuoA:
undetectable		 5wyqB-1tuoA:
23.06