SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		4 / 8 VAL A  67
LEU A  13
HIS A  90
VAL A  88
 None
 0.86A 1jtvA-1tuuA:
undetectable		 1jtvA-1tuuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 ALA A 290
ARG A 342
LEU A 302
GLU A 299
ALA A 298
 None
 1.08A 1mjqC-1tuuA:
undetectable
1mjqD-1tuuA:
undetectable		 1mjqC-1tuuA:
14.58
1mjqD-1tuuA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 ALA A 290
ARG A 342
LEU A 302
GLU A 299
ALA A 298
 None
 1.08A 1mjqI-1tuuA:
undetectable
1mjqJ-1tuuA:
undetectable		 1mjqI-1tuuA:
14.58
1mjqJ-1tuuA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 10 ASP A 283
ILE A 343
LEU A 275
ILE A 313
GLY A 212
 ADP  A 401 (-3.7A)
None
None
None
SO4  A 400 (-3.4A)
 1.30A 2v0mA-1tuuA:
undetectable		 2v0mA-1tuuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 VAL A 218
SER A 223
SER A 227
VAL A 326
LEU A 195
 None
 1.39A 2zlcA-1tuuA:
undetectable		 2zlcA-1tuuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 9 VAL A 375
LEU A 195
ARG A 376
SER A 369
GLY A 314
 None
 1.27A 3cv9A-1tuuA:
undetectable		 3cv9A-1tuuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		4 / 6 ILE A 388
TYR A 186
MET A  20
ILE A  18
 None
 1.22A 3eteA-1tuuA:
undetectable
3eteE-1tuuA:
undetectable		 3eteA-1tuuA:
24.31
3eteE-1tuuA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 9 HIS A 180
ASP A 148
HIS A 152
GLY A 181
GLU A 384
 SO4  A 400 (-3.9A)
None
None
None
None
 1.47A 3gn0B-1tuuA:
undetectable		 3gn0B-1tuuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		4 / 5 ALA A 301
GLU A 299
GLU A 303
ALA A 291
 None
 1.32A 3r9tC-1tuuA:
undetectable		 3r9tC-1tuuA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 11 ASN A 335
GLY A 331
ALA A 330
THR A 382
VAL A 187
 ADP  A 401 (-3.7A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 3.9A)
None
None
 1.17A 3rukD-1tuuA:
undetectable		 3rukD-1tuuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		6 / 11 PHE A 305
ASN A 335
GLY A 331
ALA A 330
THR A 329
VAL A 327
 None
ADP  A 401 (-3.7A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 3.9A)
None
None
 1.22A 3rukD-1tuuA:
undetectable		 3rukD-1tuuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		4 / 5 LEU A 209
GLY A 210
PHE A 284
PHE A 305
 None
ADP  A 401 (-3.3A)
ADP  A 401 (-4.3A)
None
 0.81A 3smtA-1tuuA:
undetectable		 3smtA-1tuuA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		3 / 3 HIS A 180
GLU A 384
ASN A   7
 SO4  A 400 (-3.9A)
None
None
 0.89A 4bupB-1tuuA:
undetectable		 4bupB-1tuuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 10 ASN A 383
GLY A 331
ILE A 332
VAL A 327
VAL A 187
 None
ADP  A 401 (-3.2A)
ADP  A 401 (-4.3A)
None
None
 1.03A 4j5jB-1tuuA:
undetectable		 4j5jB-1tuuA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		4 / 5 THR A 382
THR A 329
THR A 226
HIS A 152
 None
 1.28A 4pgfB-1tuuA:
undetectable		 4pgfB-1tuuA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 8 LEU A  71
GLY A  77
VAL A  78
LEU A   4
GLY A  29
 None
 1.08A 4zauA-1tuuA:
undetectable		 4zauA-1tuuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 LEU A 236
HIS A 184
GLY A 210
GLY A 239
HIS A 180
 None
None
ADP  A 401 (-3.3A)
None
SO4  A 400 (-3.9A)
 1.20A 5nnaA-1tuuA:
undetectable		 5nnaA-1tuuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 LEU A 236
HIS A 184
GLY A 210
GLY A 239
HIS A 180
 None
None
ADP  A 401 (-3.3A)
None
SO4  A 400 (-3.9A)
 1.19A 5nnaB-1tuuA:
undetectable		 5nnaB-1tuuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 LEU A 236
HIS A 184
GLY A 210
GLY A 239
HIS A 180
 None
None
ADP  A 401 (-3.3A)
None
SO4  A 400 (-3.9A)
 1.19A 5nnaC-1tuuA:
undetectable		 5nnaC-1tuuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 LEU A 236
HIS A 184
GLY A 210
GLY A 239
HIS A 180
 None
None
ADP  A 401 (-3.3A)
None
SO4  A 400 (-3.9A)
 1.21A 5nnaD-1tuuA:
undetectable		 5nnaD-1tuuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		3 / 3 HIS A 180
GLU A 384
ASN A   7
 SO4  A 400 (-3.9A)
None
None
 0.91A 5wbvA-1tuuA:
undetectable		 5wbvA-1tuuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		3 / 3 HIS A 180
GLU A 384
ASN A   7
 SO4  A 400 (-3.9A)
None
None
 0.90A 5wbvB-1tuuA:
undetectable		 5wbvB-1tuuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		4 / 5 THR A 329
THR A 226
HIS A 152
GLY A 212
 None
None
None
SO4  A 400 (-3.4A)
 1.15A 6gbnC-1tuuA:
undetectable		 6gbnC-1tuuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1tuu ACETATE KINASE
(Methanosarcina
thermophila) 		5 / 12 LEU A 195
LEU A 347
LEU A 320
GLY A 322
ILE A 205
 None
 1.06A 6qxsB-1tuuA:
undetectable		 6qxsB-1tuuA:
21.52